Results 31 to 40 of about 5,903 (227)

Pharmacogenomic-guided dosing of fluoropyrimidines beyond DPYD: time for a polygenic algorithm?

Frontiers in Pharmacology, 2023
Fluoropyrimidines are chemotherapeutic agents widely used for the treatment of various solid tumors. Commonly prescribed FPs include 5-fluorouracil (5-FU) and its oral prodrugs capecitabine (CAP) and tegafur.
Anthi Maslarinou, Anthi Maslarinou, Vangelis G. Manolopoulos, Vangelis G. Manolopoulos, Vangelis G. Manolopoulos, Georgia Ragia, Georgia Ragia   +6 more
doaj   +1 more source

Management of cytotoxic chemotherapy-induced hand-foot syndrome

Oncology Reviews, 2020
Improvements in systemic cancer treatments have resulted in more patients surviving for prolonged periods of time on treatment. This has made treatment-related toxicity and quality of life concerns increasingly relevant.
Johannes J.M. Kwakman, Yannick S. Elshot, Cornelis J.A. Punt, Miriam Koopman   +3 more
doaj   +1 more source

Growth inhibitory effects exerted by effluxed fluoropyrimidines on mutants lacking key pyrimidine salvage activities.

, 2022
(A) Evaluation of the supernatants’ impact on the colony growth of strains on solid medium. (B) Microtiter-based hyphal growth quantification and (C) representative microscopic images illustrating growth of strains in liquid AMM supplemented with ...
Luis Enrique Sastré-Velásquez (14305295), Alex Dallemulle (14305298), Laura Alcazar-Fuoli (645777), Christoph Müller (2452525), Anna Niedrig (14305304), Clara Baldin (793862), Alexander Kühbacher (14305301), Fabio Gsaller (240729)   +7 more
core   +1 more source

Awareness and attitudes of oncology specialists toward dihydropyrimidine dehydrogenase testing in Saudi Arabia

Cancer Reports, 2023
Background Fluoropyrimidines (FP) are among the most common class of prescribed anti‐neoplastic drugs. This class has severe to moderate toxicity in around 10%–40% of those who take 5‐fluorouracil (5‐FU) or capecitabine for the treatment of cancer.
Hatouf H. Sukkarieh, Turki AlSagoor, Mohammed Alnuhait, Rami Bustami, Scott Bryson, Fatima Mohammed Kebir Adem, Hana Abdalla, Gulsan Karbani   +7 more
doaj   +1 more source

A Clinical-Genetic Score to Identify Surgically Resected Colorectal Cancer Patients Benefiting From an Adjuvant Fluoropyrimidine-Based Therapy

Frontiers in Pharmacology, 2018
There are clinical challenges related to adjuvant treatment in colorectal cancer (CRC) and novel molecular markers are needed for better risk stratification of patients.
Elena De Mattia, Eva Dreussi, Marcella Montico, Sara Gagno, Chiara Zanusso, Luca Quartuccio, Salvatore De Vita, Michela Guardascione, Angela Buonadonna, Mario D’Andrea, Nicoletta Pella, Adolfo Favaretto, Enrico Mini, Stefania Nobili, Loredana Romanato, Erika Cecchin, Giuseppe Toffoli   +16 more
doaj   +1 more source

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction of DPYD and fluoropyrimidines [PDF]

, 2019
Despite advances in the field of pharmacogenetics (PGx), clinical acceptance has remained limited. The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate PGx implementation by developing evidence-based pharmacogenetics guidelines to optimize ...
Schaik, R.H.N. (Ron) van, Wilffert, B. (Bob), Lunenburg, C.A.T.C. (Carin A. T. C.), Rongen, G.A. (Gerard), van der Wouden, C.H. (Cathelijne H.), Swen, J.J. (Jesse), Nijenhuis, M. (M.), de Boer-Veger, N.J. (Nienke J.), Guchelaar, H.J. (Henk Jan), Crommentuijn-van Rhenen, M.H. (Mandy H.), Weide, J. (Jan) van der, Deneer, V.H.M. (V. H M), Houwink, E.J.F. (Elisa J. F.), Mulder, H. (Hans), Buunk, A.M. (Anne Marie)   +14 more
core   +6 more sources

A Novel DPYD Variant Associated With Severe Toxicity of Fluoropyrimidines: Role of Pre-emptive DPYD Genotype Screening

Frontiers in Oncology, 2018
Background: The fluoropyrimidine anticancer drug, especially 5- fluorouracil (5-FU) and its prodrug capecitabine are still being the backbone of chemotherapeutic regimens for colorectal cancer.
Chi C. Tong, Ching W. Lam, Ka O. Lam, Victor H. F. Lee, Mai-Yee Luk   +4 more
doaj   +1 more source

Analysis of the Thymidylate Synthase Gene Structure in Colorectal Cancer Patients and Its Possible Relation with the 5-Fluorouracil Drug Response

Journal of Nucleic Acids, 2010
Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and it is the target for the 5-Fluorouracil (5-FU) activity. Barbour et al.
A. Calascibetta, Flavia Contino, S. Feo, G. Gulotta, M. Cajozzo, A. Antona, G. Sanguedolce, R. Sanguedolce   +7 more
doaj   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

DPYD pathogenic variants associated with fluoropyrimidines toxicity [PDF]

, 2023
Background: Genetic variants in dihydropyrimidine dehydrogenase gene (DPYD) coding for the key enzyme (DPD) of fluoropyrimidines (FPs) catabolism. DPYD contributes to the development of severe FPs-related toxicity, and pathogenic DPYD variants detection ...
Burciaga-Flores, Carlos Horacio, Oliva-García, Noé Israel, Villarreal Alvarado, Francisco Javier, Vidal-Gutiérrez, Oscar, González-Guerrero, Juan Francisco, Gómez Ordaz, Valeria Jimena, Pérez-Ibave, Diana Cristina, Garza-Rodriguez, Maria de Lourdes, Cortes Alfaro, Jonatán Isaí, Ramos-Martínez, Irasema   +9 more
core   +1 more source