Results 231 to 240 of about 102,435 (279)
Some of the next articles are maybe not open access.
Infectious Disease Clinics of North America, 1995
Since the introduction of the floroquinolones for clinical use in the late 1980s, they have been used successfully for a large number of clinical situations. As experience accumulates, the indications and optimal use of these agents gradually become more clear.
openaire +2 more sources
Since the introduction of the floroquinolones for clinical use in the late 1980s, they have been used successfully for a large number of clinical situations. As experience accumulates, the indications and optimal use of these agents gradually become more clear.
openaire +2 more sources
Mayo Clinic Proceedings, 1999
The quinolones are broad-spectrum antibacterial agents that have a novel mechanism of action. As synthetic compounds, these agents have been developed extensively to optimize antimicrobial activity, pharmacokinetic properties, and drug safety. Although earlier quinolones were effective only in the genitourinary and gastrointestinal tracts and only had ...
openaire +2 more sources
The quinolones are broad-spectrum antibacterial agents that have a novel mechanism of action. As synthetic compounds, these agents have been developed extensively to optimize antimicrobial activity, pharmacokinetic properties, and drug safety. Although earlier quinolones were effective only in the genitourinary and gastrointestinal tracts and only had ...
openaire +2 more sources
Infectious Disease Clinics of North America, 2004
This article discusses the newer fluoroquinolones in detail with respect to their pharmacokinetics, pharmacodynamics, safety, and spectrum of in vitro activity. The newer agents are compared and contrasted with the older ones, particularly ciprofloxacin.
Judith A, O'Donnell, Steven P, Gelone
openaire +2 more sources
This article discusses the newer fluoroquinolones in detail with respect to their pharmacokinetics, pharmacodynamics, safety, and spectrum of in vitro activity. The newer agents are compared and contrasted with the older ones, particularly ciprofloxacin.
Judith A, O'Donnell, Steven P, Gelone
openaire +2 more sources
Fluoroquinolones in Paediatrics
Paediatric Drugs, 2001The fluoroquinolones are an important group of antibiotics, which are widely used in adult patients because of their high penetration in tissues and bactericidal activity. However, they are not licensed for paediatric use (except the limited indication of Pseudomonas infection in cystic fibrosis) because of their potential to cause joint toxicity ...
D, Gendrel, F, Moulin
openaire +2 more sources
Photophysics and photochemistry of fluoroquinolones
Chemical Society Reviews, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
A Albini, S Monti
openaire +3 more sources
Fluoroquinolones in the treatment of meningitis
Current Infectious Disease Reports, 2003The continuous increase of resistant pathogens causing meningitis has limited the efficacy of standard therapeutic regimens. Due to their excellent activity in vitro and their good penetration into the cerebrospinal fluid (CSF), fluoroquinolones appear promising for the treatment of meningitis caused by gram-negative microorganisms, ie, Neisseria ...
Cottagnoud P, Täuber MG
openaire +3 more sources
Medical Clinics of North America, 2009
Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and ...
openaire +3 more sources
Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and ...
openaire +3 more sources
Mast cell‐mediated hypersensitivity to fluoroquinolone is MRGPRX2 dependent
International Immunopharmacology, 2019Fluoroquinolones trigger anaphylaxis during clinical applications, affecting the safety of their administration. Mast cells are immune cells that act as sentinels during host defenses, mediating hypersensitivity and anaphylactic reactions.
Rui Liu +9 more
semanticscholar +1 more source
The Indian Journal of Pediatrics, 2000
Abstract The original quinolone, nalidixic acid, was discovered in the 1960s as a byproduct of the purification of the antimalarial drug, chloroquine.4 Unfortunately, nalidixic acid has a narrow antibacterial spectrum, with activity mainly against gram-negative organ isms. Nalidixic acid penetrates poorly into the tissues; thus it can be
Eric M Scholar, William B Pratt
openaire +2 more sources
Abstract The original quinolone, nalidixic acid, was discovered in the 1960s as a byproduct of the purification of the antimalarial drug, chloroquine.4 Unfortunately, nalidixic acid has a narrow antibacterial spectrum, with activity mainly against gram-negative organ isms. Nalidixic acid penetrates poorly into the tissues; thus it can be
Eric M Scholar, William B Pratt
openaire +2 more sources