Results 51 to 60 of about 5,793,605 (328)

Chromosomal and plasmid-mediated fluoroquinolone resistance in human Salmonella enterica infection in Ghana

BMC Infectious Diseases, 2019
BackgroundSalmonella infection poses significant public health threat globally, especially in resource-limited countries. Emergence and spread of antibiotic resistant strains to fluoroquinolones have led to treatment failures and increased mortality in ...
G. Acheampong, M. Owusu, A. Owusu-Ofori, Isaac Osei, N. Sarpong, A. Sylverken, H. Kung, Shu-Ting Cho, Chih-Horng Kuo, S. E. Park, F. Marks, Y. Adu-Sarkodie, E. Owusu-Dabo   +12 more
semanticscholar   +1 more source

P601 Macrolide and fluoroquinolone resistance-associated mutations in mycoplasma genitalium: a systematic review and meta-analysis

Poster Presentations, 2019
Background Treatment for Mycoplasma genitalium is becoming increasingly complicated by antimicrobial resistance. We summarised published global data on the prevalence of macrolide and fluoroquinolone resistance-associated mutations in M.
Dorothy A. Machalek, Yusha Tao, Hannah S Shilling, J. S. Jensen, M. Unemo, G. Murray, Eric P. F. Chow, N. Low, S. Garland, Christopher K. Fairley, L. Vodstrcil, J. Hocking, Lei Zhang, Catriona S. Bradshaw   +13 more
semanticscholar   +1 more source

Target-Mediated Fluoroquinolone Resistance in Neisseria gonorrhoeae: Actions of Ciprofloxacin against Gyrase and Topoisomerase IV

ACS Infectious Diseases
Fluoroquinolones are a critically important class of antibacterials administered worldwide to treat human infections. However, their clinical utility has been curtailed by target-mediated resistance, which is caused by mutations in the fluoroquinolone ...
Jessica A Collins, Alexandria A. Oviatt, Pan F Chan, Neil Osheroff   +3 more
semanticscholar   +1 more source

Acquisition of fluoroquinolone resistance leads to increased biofilm formation and pathogenicity in Campylobacter jejuni

Scientific Reports, 2019
The World Health Organization has listed C. jejuni as one of 12 microorganisms on a global priority list for antibiotic resistance due to a rapid increase in strains resistant to fluoroquinolone antibiotics.
Matthew V. X. Whelan, L. Ardill, Kentaro Koide, C. Nakajima, Yasuhiko Suzuki, Jeremy C. Simpson, Tadhg Ó. Cróinín   +6 more
semanticscholar   +1 more source

Fluoroquinolone resistance in Salmonella: insights by whole-genome sequencing

Microbial Genomics, 2018
Fluoroquinolone (FQ)-resistant Salmonella spp. were listed by the WHO in 2017 as priority pathogens for which new antibiotics were urgently needed. The overall global burden of Salmonella infections is high, but differs per region.
Wim L. Cuypers, J. Jacobs, V. Wong, Elizabeth J. Klemm, S. Deborggraeve, S. Van Puyvelde   +5 more
semanticscholar   +1 more source

Genotypic and phenotypic characterization of Mycobacterium tuberculosis resistance against fluoroquinolones in the northeast of Iran

BMC Infectious Diseases, 2020
Background Fluoroquinolones are broad-spectrum antibiotics that are recommended, and increasingly important, for the treatment of multidrug-resistant tuberculosis (MDR-TB). Resistance to fluoroquinolones is caused by mutations in the Quinolone Resistance
Mahdieh Sayadi, Hosna Zare, Saeed Amel Jamedar, Seyed Isaac Hashemy, Zahra Meshkat, Saman Soleimanpour, Sven Hoffner, Kiarash Ghazvini   +7 more
doaj   +1 more source

Molecular surveillance of rising fluoroquinolone resistance in non-invasive S. pneumoniae isolates in Belgium collected in a survey (1995-2014)

, 2015
<p>We present the results of a longitudinal surveillance study (1995-2014) on fluoroquinolone resistance (FQ-R) among Belgian non-invasive Streptococcus pneumoniae isolates (n = 5,602). For many years, the switch to respiratory fluoroquinolones for
P.J. Ceyssens, E. Van Bossuyt, J. Verhaegen, P.M. Tulkens, S. Bertrand, The Belgian Streptococcus pneumoniae study group, H.J. Nyssen, R. Vanhoof, F. Fux, S. Damee, W. Mattheus, F. Van Bambeke   +11 more
core   +1 more source

Increased fluoroquinolone resistance with time in Escherichia coli from >17,000 patients at a large county hospital as a function of culture site, age, sex, and location

BMC Infectious Diseases, 2008
Background Escherichia coli infections are common and often treated with fluoroquinolones. Fluoroquinolone resistance is of worldwide importance and is monitored by national and international surveillance networks.
Hamill Richard J, Randall Graham L, Atmar Robert L, Boyd Lauren, Steffen David, Zechiedrich Lynn   +5 more
doaj   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

The roles of mutations in gyrA, parC, and ompK35 in fluoroquinolone resistance in Klebsiella pneumoniae

, 2008
[[abstract]]In a survey of 541 Klebsiella pneumoniae isolates from 44 hospitals in Taiwan, three distinct populations were identified by the disk diffusion method according to the disribution of zone diameters of ciprofloxacin.
Chen, FJ; Lauderdale, TL; Ho, M; Lo, HJ
core   +1 more source