Results 111 to 120 of about 56,658 (237)

Factors Influencing Fluoroquinolone Resistance

Emerging Infectious Diseases, 2003
Daniel F. Sahm, Clyde Thornsberry, Mark E. Jones, James A. Karlowsky   +3 more
doaj   +1 more source

Adverse events in bedaquiline‐ and pretomanid‐based regimens for drug‐resistant tuberculosis from trial, implementation and pharmacovigilance studies

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2607-2623, August 2026.
Abstract The availability of safety data, particularly concerning adverse events (AEs) associated with the new shorter regimen for drug‐resistant tuberculosis (TB) containing a bedaquiline–pretomanid‐based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by ...
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin‐Gun Cho, Jan‐Willem C. Alffenaar   +4 more
wiley   +1 more source

Ciprofloxacin‐Induced Near‐Total Toxic Epidermal Necrolysis Complicated by Upper Gastrointestinal Bleeding: A Case Report With ALDEN‐Based Causality Assessment

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Toxic epidermal necrolysis (TEN) is a rare but life‐threatening mucocutaneous adverse drug reaction characterized by widespread epidermal necrosis and detachment with significant mucosal involvement. We report a case of near total (80%–90%) body surface area TEN in a previously healthy 30‐year‐old man that developed approximately 5 days after ...
Amanuel D. Wakoya, Alemu B. Mesekere, Seid A. abdullahi, Misale B. Tesfaye, Zeynu H. Endris, Zelalem G. Demissie, Tibebu G. Haile   +6 more
wiley   +1 more source

Harnessing Repurposed Drugs to Enhance Temozolomide Efficacy in Glioblastoma

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Glioblastoma (GB) is the most aggressive primary malignant brain tumor in adults and remains associated with poor survival despite surgical resection followed by radiotherapy and temozolomide (TMZ) chemotherapy. Intrinsic and acquired resistance to TMZ, including MGMT‐dependent DNA repair and activation of pro‐survival pathways ...
Ali Nakhaei, Atefeh Taghavi, Amir R. Afshari, Farzaneh Davoudi, Elaheh Gheybi, Mohammad Jalili‐Nik   +5 more
wiley   +1 more source

Disproportionality and Case-Based Evidence for a Possible Association Between Fluoroquinolones and Kounis Syndrome. [PDF]

Pharmaceuticals (Basel)
Cmiljanić M, Milosavljević M, Jovčić F, Pavlović M, Stefanović S.   +4 more
europepmc   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 501-509, August 2026.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

Fluoroquinolone prescribing to older adults following FDA boxed warnings: a comparative analysis. [PDF]

Antimicrob Steward Healthc Epidemiol
Jia M, Flory J, McGinty EE, Rosen T, Zhang Y.   +4 more
europepmc   +1 more source

Two Novel 1,4‐Naphthoquinone Derivatives as Potent Agents Against Multidrug‐Resistant Staphylococcus aureus and Pathogenic Gram‐Positive Bacteria

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Drug‐resistant bacteria such as Methicillin‐resistant Staphylococcus aureus (MRSA) and Quinolone‐resistant S. aureus (QRSA), are a growing problem, creating a need for the development of novel antimicrobial agents. In this study, we designed and synthesized two novel 1,4‐naphthoquinone derivatives, LHN‐1034 and LHN‐1035, and evaluated their ...
HyunChan Song, Haena Lee, Ji‐Hyun Yoon, Hyunkyung Choi, Hakwon Kim, Ki‐Young Kim   +5 more
wiley   +1 more source

Fluoroquinolones as the linchpin of tuberculosis therapy: contrasting efficacy and resistance profiles in <i>Mycobacterium tuberculosis</i> versus <i>Mycobacterium abscessus</i>. [PDF]

Front Cell Infect Microbiol
Kuzioła M, Korycka-Machała M, Zygała-Pytlos D, Dziadek B, Kawka M, Pawełczyk J, Odolczyk N, Zielenkiewicz P, Słomka M, Dziadek J.   +9 more
europepmc   +1 more source

Ultra‐Sensitive Amperometric Detection of Ciprofloxacin in Environmental and Biological Matrices Using an ITO Modified With Tungsten Trioxide‐Based Nanocomposite

Electrochemical Science Advances, Volume 6, Issue 4, August 2026.
ABSTRACT Although significant progress has been achieved in the electrochemical sensing of ciprofloxacin (CIP), there remains a critical need for highly sensitive and reliable platforms capable of rapid charge transfer and accurate detection at trace levels in complex environmental and biological matrices.
Amira Nahdi, Mabrouka Ghiloufi, Fathi Touati, Hassouna Dhaouadi, Tobias Schnabel, Nicole Jaffrezic‐Renault, Salah Kouass, Hamdi Ben Halima   +7 more
wiley   +1 more source