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Medical Clinics of North America, 2009
Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and ...
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Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and ...
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The Role of the Fluoroquinolones
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1992Over the past decade, the quinolone antimicrobial class has enjoyed a renaissance with the emergence of the fluoroquinolone subclass. Norfloxacin, ciprofloxacin, ofloxacin, enoxacin, and lomefloxacin have the advantages of broad antimicrobial activity profiles including gram‐positive and ‐negative aerobes, favorable pharmacokinetic
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Drug and Therapeutics Bulletin, 1994
Two fluoroquinolone antibiotics, ciprofloxacin (Ciloxan - Alcon) and ofloxacin (Exocin - Allergan), are available in the UK as topical preparations for the eye.* Ciprofloxacin eyedrops are licensed for the treatment of "corneal ulcers and superficial infections of the eye", and ofloxacin eyedrops for "external ocular infections (such as conjunctivitis ...
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Two fluoroquinolone antibiotics, ciprofloxacin (Ciloxan - Alcon) and ofloxacin (Exocin - Allergan), are available in the UK as topical preparations for the eye.* Ciprofloxacin eyedrops are licensed for the treatment of "corneal ulcers and superficial infections of the eye", and ofloxacin eyedrops for "external ocular infections (such as conjunctivitis ...
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Drugs, 2001
The fluoroquinolones have become widely used antibacterial agents in the treatment of ocular infections, with topical, intravitreal and systemic routes of administration being used. In general, fluoroquinolones (such as ciprofloxacin, ofloxacin, lomefloxacin and norfloxacin) have good activity against gram-negative and gram-positive bacteria ...
A, Smith +3 more
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The fluoroquinolones have become widely used antibacterial agents in the treatment of ocular infections, with topical, intravitreal and systemic routes of administration being used. In general, fluoroquinolones (such as ciprofloxacin, ofloxacin, lomefloxacin and norfloxacin) have good activity against gram-negative and gram-positive bacteria ...
A, Smith +3 more
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Drugs, 1995
The main types of adverse effects associated with quinolones are uncommon and reversible and vary in frequency among different agents. Phototoxicity appears more frequent with lomefloxacin than with some other quinolones. Three mechanisms have been proposed to explain the neurotoxic effects, including rare proconvulsant activity, associated with ...
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The main types of adverse effects associated with quinolones are uncommon and reversible and vary in frequency among different agents. Phototoxicity appears more frequent with lomefloxacin than with some other quinolones. Three mechanisms have been proposed to explain the neurotoxic effects, including rare proconvulsant activity, associated with ...
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2000
Abstract The original quinolone, nalidixic acid, was discovered in the 1960s as a byproduct of the purification of the antimalarial drug, chloroquine.4 Unfortunately, nalidixic acid has a narrow antibacterial spectrum, with activity mainly against gram-negative organ isms. Nalidixic acid penetrates poorly into the tissues; thus it can be
Eric M Scholar, William B Pratt
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Abstract The original quinolone, nalidixic acid, was discovered in the 1960s as a byproduct of the purification of the antimalarial drug, chloroquine.4 Unfortunately, nalidixic acid has a narrow antibacterial spectrum, with activity mainly against gram-negative organ isms. Nalidixic acid penetrates poorly into the tissues; thus it can be
Eric M Scholar, William B Pratt
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Journal of the American Academy of Orthopaedic Surgeons, 2002
Alan M, Levine, John R, DiBona
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Alan M, Levine, John R, DiBona
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Postgraduate Medicine, 1991
Fluoroquinolones are the newest antibiotics for treatment of some infections caused by highly resistant bacteria (eg, Pseudomonas aeruginosa). Clinically sound indications for these drugs include resistant infections of the urinary, intestinal, and respiratory tracts; otitis externa; osteomyelitis; foot infections in diabetic patients; and late ...
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Fluoroquinolones are the newest antibiotics for treatment of some infections caused by highly resistant bacteria (eg, Pseudomonas aeruginosa). Clinically sound indications for these drugs include resistant infections of the urinary, intestinal, and respiratory tracts; otitis externa; osteomyelitis; foot infections in diabetic patients; and late ...
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Classification of fluoroquinolones
International Journal of Antimicrobial Agents, 1998K G, Naber, D, Adam
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Degradation of fluoroquinolones in homogeneous and heterogeneous photo-Fenton processes: A review
Chemosphere, 2021Shaoxian Song, Lang Yang, Lai Peng
exaly