Results 11 to 20 of about 290,304 (371)

5‐Fluorouracil resistance mechanisms in colorectal cancer: From classical pathways to promising processes

Cancer Science, 2020
Colorectal cancer (CRC) is a public health problem. It is the third most common cancer in the world, with nearly 1.8 million new cases diagnosed in 2018. The only curative treatment is surgery, especially for early tumor stages.
S. Blondy, Valentin David, M. Verdier, M. Mathonnet, A. Perraud, N. Christou   +5 more
semanticscholar   +1 more source

Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of Fluorouracil

Frontiers in Chemistry, 2020
Dynamic hydrogels have been prepared by cross-linking of O-carboxymethyl chitosan (O-CMCS) with reversibly connected imino-PEGylated dynamers. The double imine chitosan/dynamer and dynamer bonds and were used to provide tighter structures and adaptive ...
Yan Zhang, Chi-Yen Pham, Rui Yu, Eddy Petit, Suming Li, Mihail Barboiu   +5 more
doaj   +1 more source

Weekly irinotecan in a patient with metastatic colorectal cancer on hemodialysis due to chronic renal failure [PDF]

, 2002
Background: The cytotoxic treatment of patients suffering from advanced or metastatic cancer undergoing hemodialysis due to chronic renal failure still remains a problem, since for those patients pharmacokinetic and pharmacodynamic data on most cytotoxic
Hacker, U., Heinemann, Volker, Schalhorn, A., Stemmler, J., Weise, A.   +4 more
core   +1 more source

5-Fluorouracil combined with cisplatin via arterial induction for advanced T-stage nasopharyngeal carcinoma: A 10-year outcome of a phase I/II study

Frontiers in Oncology, 2022
Background and PurposeCurrently, there is no optimal dose recommendation for a 120-h continuous infusion of 5-fluorouracil via arterial cannulation for advanced T-stage nasopharyngeal carcinoma (NPC).
Li Xiang, Yun Zheng, PeiRong Ren, Sheng Lin, JianWen Zhang, QingLian Wen, LiJia He, ChangLing Shang, JingBo Wu   +8 more
doaj   +1 more source

Induction chemotherapy in locally advanced squamous cell carcinoma of the head and neck: role, controversy, and future directions. [PDF]

, 2018
BackgroundThe value of induction chemotherapy (ICT) remains under investigation despite decades of research. New advancements in the field, specifically regarding the induction regimen of choice, have reignited interest in this approach for patients with
Cohen, EEW, Haddad, RI, Hitt, R, Lefebvre, J-L, Posner, M, Schulten, J, Vermorken, JB   +6 more
core   +1 more source

High incidence of Angina pectoris in patients treated with 5-fluorouracil - A planned surveillance study with 102 patients [PDF]

, 2003
Objective: Angina pectoris, arrhythmic sudden death and myocardial infarction, all these cardiac events have occasionally been reported during 5-fluorouracil (5-FU) chemotherapy.
Lersch, C., Reindl, L., Scherpinski, U., Seyfarth, M., Wacker, A.   +4 more
core   +1 more source

Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial

The Lancet, 2019
BACKGROUND Docetaxel-based chemotherapy is effective in metastatic gastric and gastro-oesophageal junction adenocarcinoma. This study reports on the safety and efficacy of the docetaxel-based triplet FLOT (fluorouracil plus leucovorin, oxaliplatin and ...
S. Al-Batran, N. Homann, C. Pauligk, T. Goetze, J. Meiler, S. Kasper, H. Kopp, F. Mayer, G. Haag, K. Luley, U. Lindig, W. Schmiegel, M. Pohl, J. Stoehlmacher, G. Folprecht, S. Probst, N. Prasnikar, W. Fischbach, R. Mahlberg, J. Trojan, M. Koenigsmann, U. Martens, P. Thuss-Patience, M. Egger, A. Block, V. Heinemann, G. Illerhaus, M. Moehler, M. Schenk, F. Kullmann, D. Behringer, M. Heike, D. Pink, C. Teschendorf, Carmen Löhr, H. Bernhard, G. Schuch, V. Rethwisch, L. F. V. Weikersthal, J. Hartmann, M. Kneba, S. Daum, K. Schulmann, J. Weniger, S. Belle, T. Gaiser, F. Oduncu, M. Güntner, W. Hozaeel, Alexander Reichart, E. Jäger, T. Kraus, S. Mönig, W. Bechstein, M. Schuler, H. Schmalenberg, R. Hofheinz   +56 more
semanticscholar   +1 more source

Colchicine Ameliorates 5-Fluorouracil-Induced Cardiotoxicity in Rats

Oxidative Medicine and Cellular Longevity, 2022
Background and Objective. 5‐Fluorouracil is one of the most common chemotherapeutic agents used in the treatment of solid tumors. 5‐Fluorouracil‐associated cardiotoxicity is the second cause of cardiotoxicity induced by chemotherapeutic drugs after ...
Soheila Safarpour, Samaneh Safarpour, Marzieh Pirzadeh, A. Moghadamnia, A. Ebrahimpour, Fatemeh Shirafkan, Razieh Mansoori, S. Kazemi, M. Hosseini   +8 more
semanticscholar   +1 more source

The rate of cardiac complications in patients receiving a 24-hour dose of 5-Fluorouracil [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023
Background. Cardiotoxicity caused by fluoropyrimidines is an uncommon but potentially fatal complication. Its frequency has been 1.6 to 19% in previous studies. But there are no accurate statistics in Iran. The aim of this study was to determine the rate
Mostafa Davoodnataj, Mohsen Vakili Sadeghi, Naghmeh Zieaie Amiri, Majid Nabipour, Hemmat Gholinia Ahangar   +4 more
doaj   +1 more source

Topoisomerase expression and amplification in solid tumours: Analysis of 24,262 patients. [PDF]

, 2017
BackgroundTopoisomerase I (TOPO1) and topoisomerase IIα (TOP2A) are specific targets of multiple chemotherapy drugs. Increased expression of TOPO1 protein and amplification of the TOP2A gene have been associated with treatment response in colorectal and ...
Arguello, David, Gatalica, Zoran, Heestand, Gregory M, Kurzrock, Razelle, Schwaederle, Maria   +4 more
core   +1 more source