Results 31 to 40 of about 142,003 (296)

Therapeutic methods and effect on keloid and hypertrophic scars: a systematic review

Frontiers in Medicine
BackgroundKeloids and hypertrophic scars are fibroproliferative disorders with high recurrence rates, lacking a definitive treatment standard. This review systematically evaluates current therapies and their effectiveness in treating keloid and ...
Yuhang Shen, Lirong Yang, Dayong Feng, Chunhui Wang, Zhiyong Bai, Xi Wang, Jingwen Wang, Yuening Feng, Ayue An   +8 more
doaj   +1 more source

Curcuma longa extract protects against 5-fluorouracil-induced oral mucositis in hamsters

, 2022
Curcumin, contained at Turmeric (Curcumalonga), can exert many beneficial pleiotropic activities in the gastrointestinal tract. This study evaluated the antioxidant and anti-inflammatory activity of C.
Luiz Alberto Lira Soares (3607856), Maria Luiza Diniz de Sousa Lopes (14073330), Edna Maria Silva (14073315), Amanda Lanna Andrade Barbalho (14073321), Iolanda Augusta Fernandes de Matos (14073324), Janaina Carla Barbosa Machado (14073336), Matheus Araujo dos Santos (14073327), Caroline Addison Carvalho Xavier de Medeiros (14073333), Aurigena Antunes de Araújo (14073312), Cristiane Assunção da Costa Cunha Mafra (14073318), Raimundo Fernandes de Araújo (14073339), Magda Rhayanny Assunção Ferreira (7492277), Rubens Maribondo do Nascimento (5528156), Íris do Céu Clara Costa (10399338), Gerlane Coelho Bernardo Guerra (5379341)   +14 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Severe immune-related autoimmune hemolytic anemia induced by pembrolizumab: a case report with novel immunosuppressive strategy

Frontiers in Immunology
IntroductionImmune checkpoint inhibitors (ICIs), including PD-1 inhibitors, have significantly improved survival outcomes in patients with melanoma; however, serious adverse events may occur as a consequence of immune dysregulation.
Qin Ye, Meng Li, Ping Zhou, Shan Huang, Ke Xie   +4 more
doaj   +1 more source

Xanthine Oxidase Inhibitor, Febuxostat Is Effective against 5-Fluorouracil-Induced Parotid Salivary Gland Injury in Rats Via Inhibition of Oxidative Stress, Inflammation and Targeting TRPC1/CHOP Signalling Pathway

Pharmaceuticals, 2022
The current research aimed to examine the ameliorative role of febuxostat (FEB), a highly potent xanthine oxidase inhibitor, against 5-fluorouracil (5-FU)-induced parotid salivary gland damage in rats, as FEB is a pleiotropic drug that has multiple ...
Walaa Yehia Abdelzaher, Mohamed A. Nassan, Sabreen Mahmoud Ahmed, Nermeen N. Welson, Gaber El-Saber Batiha, Hanaa Mohamed Khalaf   +5 more
doaj   +1 more source

Gemcitabine: Progress in the treatment of pancreatic cancer [PDF]

, 2001
Unresectable pancreatic cancer has a dismal prognosis with a median survival of 3-5 months in untreated disease. Since the introduction of gemcitabine, pancreatic cancer may no longer be regarded a chemotherapy-resistant tumor.
Heinemann, Volker
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Fluorouracil Supplemented With Oxaliplatin or Irinotecan for Solid Tumors: Indications From Clinical Characteristics and Health Outcomes of Patients

Frontiers in Oncology, 2020
Fluorouracil combined with oxaliplatin (FOLFOX) and fluorouracil combined with irinotecan (FOLFIRI) are both first-line clinical chemotherapy regimens. However, clinicians' selection of FOLFIRI or FOLFOX medication regimens and their effects on patients'
Zhao Qingwei, Zhao Qingwei, Hong Dongsheng, Lv Duo, Lv Duo, Wang Youlei, Yu Songxia, Ye Ziqi, Li Lanjuan   +8 more
doaj   +1 more source

Increased response of oxaliplatin or irinotecan on chemosensitivity to 5-fluorouracil in patients with colorectal cancer [PDF]

Korean Journal of Clinical Oncology, 2014
Purpose: Five-fluorouracil (5-FU) is the basement drug of chemotherapy in patients with colorectal cancer. Recently, 5-FU and oxaliplatin or irinotecan is to be used by merging.
Se Na Cho, Kyung Jong Kim
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source