Results 21 to 30 of about 142,003 (296)

Can localised 19F magnetic resonance spectroscopy pharmacokinetics of 5FU in colorectal metastases predict clinical response? [PDF]

, 2010
Background 5-Fluorouracil remains widely used in colorectal cancer treatment more than 40 years after its development. 19F magnetic resonance spectroscopy can be used in vivo to measure 5FU’s half-life and metabolism to cytotoxic fluoronucleotides ...
Griffiths, John R., Ladroue, Christophe, Lofts, F, Lofts, Fiona, Griffiths, JR, John R. Griffiths, Marion Stubbs, Stubbs, Marion, Franklyn A. Howe, Fiona Lofts, McIntyre, DJ, Ladroue, C, Howe, FA, Howe, Franklyn A., McIntyre, Dominick J. O., Dominick J. O. McIntyre, Stubbs, M, Christophe Ladroue   +17 more
core   +1 more source

Modification of 5-fluorouracil with thiourea and benzoyl groups and in silico study on thymidylate synthase enzyme as an anticancer candidate [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Cancer remains the leading cause of death worldwide, so new therapeutic strategies are needed. 5-Fluorouracil (5-FU) has been widely used in chemotherapy, but its effectiveness is limited by side effects and drug resistance.
Ruswanto Ruswanto, Tita Nofianti, Indra Indra, Richa Mardianingrum, Sofa Fajriah, Aska Reisya Aulia, Zahra Putri Handirana, Sheilla Fitriani Zahwa   +7 more
doaj   +1 more source

Intestinal alkaline phosphatase activity as a molecular marker of enterotoxicity induced by single dose of 5-fluorouracil and protective role of orally administered glutamine [PDF]

Archive of Oncology, 2006
Background. One of the critical limitations for the administration of the chemotherapy is the toxicity affecting normal tissue. The main target organs for 5-fluorouracil (5-FU) toxicity in humans and experimental animals are the gastrointestinal tract ...
Bajin-Katić Katica, Stankov Karmen, Đolai Matilda, Kovačević Zoran   +3 more
doaj   +1 more source

Capecitabine as second-line treatment for metastatic cholangiocarcinoma: A report of two cases [PDF]

, 2002
Background: The management of recurrent, metastatic cholangiocarcinoma still remains a problem since this tumor entity is classified as chemotherapy-resistant.
Schalhorn, A., Stemmler, Joachim, Heinemann, Volker   +2 more
core   +1 more source

The Impact of Metformin on the Development of Hypothyroidism and Cardiotoxicity Induced by Cyclophosphamide, Methotrexate, and Fluorouracil in Rats

Pharmaceuticals, 2023
Cyclophosphamide (CYP), methotrexate (MTX), and 5-fluorouracil (5-FU) are extensively utilized in the therapeutic management of various malignancies. It is noteworthy, however, that potential chemotherapy-related complications include the occurrence of ...
Ahmad H. Alhowail, Maha A. Aldubayan
doaj   +1 more source

Study of Human Albumin Protein Interaction with Fluorouracil Anticancer Drug Using Molecular Docking Method

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2022
Introduction: Drugs are mainly delivered to the target tissues by plasma proteins, such as human serum albumin, in the human body. Practical information about the thermodynamic parameters of drugs and their stability can be obtained using simulation ...
Mohammad Motaharinia, Mahdieh Sadeghpour, Monir Shalbafan   +2 more
doaj  

A Bibliometric Analysis of Cyclophosphamide, Methotrexate, and Fluorouracil Breast Cancer Treatments: Implication for the Role of Inflammation in Cognitive Dysfunction

Frontiers in Molecular Biosciences, 2021
Inflammation is considered one of the possible mechanisms behind long-term cognitive dysfunction persistent after chemotherapy treatment. The chemotherapy combination of cyclophosphamide, methotrexate, and fluorouracil (CMF) was one of the older methods ...
Christa Corley, Christa Corley, Antiño R. Allen, Antiño R. Allen, Antiño R. Allen   +4 more
doaj   +1 more source

Synthesis and in vitro anticancer properties of a novel neodymium(III) complex containing tungstogermanate and 5-fluorouracil

, 2018
A novel neodymium(III) complex containing tungstogermanate and 5-fluorouracil, K11(C4H4FN2O2)2Nd(GeW11O39)2·15H2O (FNdGeW), was synthesized and its structure was characterized by 1H NMR, IR, XRD, and TG-DSC.
Qingyin Wu (4783203), Zengqiang Li (725869), Haibin Liu (403499), Ce Zhao (5183348), Danfeng Zhang (1643638), Baoyang Zhou (5183345)   +5 more
core   +1 more source

Preoperative chemoradiation in locally advanced rectal cancer: A comparison of bolus 5-fluorouracil/leucovorin and capecitabine

The Saudi Journal of Gastroenterology, 2014
Purpose: To compare the acute toxicities, pathologic response, surgical margins, downstaging, local control, disease-free survival (DFS), and overall survival (OS) in locally advanced rectal cancer patients with preoperative radiotherapy (RT) with either
Adnan Yoney, Levent Isikli
doaj   +1 more source

Disulfiram/Copper Complex Induces Cytotoxicity in Pancreatic Cancer Cells and 5-Fluorouracil-Resistant Cells through Nuclear Factor E2-Related Factor-2 Suppression and Reactive Oxygen Species Modulation

Gut and Liver
Background/Aims : Pancreatic ductal adenocarcinoma (PDAC) is a challenging cancer to treat and has a poor prognosis and limited treatment options. In this study, the anticancer effects of disulfiram combined with copper (DSF/Cu) on PDAC cells, including ...
Eun Kyoung Kim, Cheong Ran Je, Sung Ill Jang, Jung Hyun Jo, See Young Lee, Young Ju Lee, Jae Hee Cho   +6 more
doaj   +1 more source