Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of Fluorouracil
Frontiers in Chemistry, 2020 Dynamic hydrogels have been prepared by cross-linking of O-carboxymethyl chitosan (O-CMCS) with reversibly connected imino-PEGylated dynamers. The double imine chitosan/dynamer and dynamer bonds and were used to provide tighter structures and adaptive ...
Yan Zhang +5 more
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Frontiers in Oncology, 2022 Background and PurposeCurrently, there is no optimal dose recommendation for a 120-h continuous infusion of 5-fluorouracil via arterial cannulation for advanced T-stage nasopharyngeal carcinoma (NPC).
Li Xiang +8 more
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THADA inhibits autophagy and increases 5-FU sensitivity in gastric cancer cells via the PI3K/AKT/mTOR signaling pathway [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): 5-Fluorouracil (5-FU) is currently the main drug used in chemotherapy for gastric cancer (GC). The main clinical problems of 5-FU therapy are insensitivity and acquired resistance to 5-FU.
Xianke Lin +3 more
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The rate of cardiac complications in patients receiving a 24-hour dose of 5-Fluorouracil [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023 Background. Cardiotoxicity caused by fluoropyrimidines is an uncommon but potentially fatal complication. Its frequency has been 1.6 to 19% in previous studies. But there are no accurate statistics in Iran. The aim of this study was to determine the rate
Mostafa Davoodnataj +4 more
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Pharmaceuticals, 2021 Irinotecan (CPT-11) is widely used for the treatment of unresectable colorectal cancer in combination with fluoropyrimidines, such as 5-fluorouracil and S-1.
Mashiro Okunaka +4 more
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5FU-loaded PCL/Chitosan/Fe3O4 Core-Shell Nanofibers Structure: An Approach to Multi-Mode Anticancer System [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose: 5-Fluorouracil (5FU) and Fe3O4 nanoparticles were encapsulated in core-shellpolycaprolactone (PCL)/chitosan (CS) nanofibers as a multi-mode anticancer system to studydrug release sustainability.
Mehdi Hadjianfar +4 more
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Hepatology, EarlyView., 2022 Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou +13 more
wiley +1 more source
Modification of 5-fluorouracil with thiourea and benzoyl groups and in silico study on thymidylate synthase enzyme as an anticancer candidate [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Cancer remains the leading cause of death worldwide, so new therapeutic strategies are needed. 5-Fluorouracil (5-FU) has been widely used in chemotherapy, but its effectiveness is limited by side effects and drug resistance.
Ruswanto Ruswanto +7 more
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Intestinal alkaline phosphatase activity as a molecular marker of enterotoxicity induced by single dose of 5-fluorouracil and protective role of orally administered glutamine [PDF]
Archive of Oncology, 2006 Background. One of the critical limitations for the administration of the chemotherapy is the toxicity affecting normal tissue. The main target organs for 5-fluorouracil (5-FU) toxicity in humans and experimental animals are the gastrointestinal tract ...
Bajin-Katić Katica +3 more
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