Results 51 to 60 of about 142,003 (296)

5-Fluorouracil: A Narrative Review on the Role of Regulatory Mechanisms in Driving Resistance to This Chemotherapeutic Agent

Frontiers in Oncology, 2021
5-fluorouracil (5-FU) is among the mostly administrated chemotherapeutic agents for a wide variety of neoplasms. Non-coding RNAs have a central impact on the determination of the response of patients to 5-FU.
Soudeh Ghafouri-Fard, Atefe Abak, Farhad Tondro Anamag, Hamed Shoorei, Faranak Fattahi, Faranak Fattahi, Seyed Alireza Javadinia, Abbas Basiri, Mohammad Taheri   +8 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Figure_S1 – Supplemental material for BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil

, 2019
Supplemental material, Figure_S1 for BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil by Yi Jer Tan, Yeuan Ting Lee, Sven H. Petersen, Gurjeet Kaur, Koji Kono, Soo Choon Tan, Amin M. S. Abdul
Yeuan Ting Lee (7441580), Soo Choon Tan (1974859), Chern Ein Oon (7441589), Koji Kono (142779), Yi Jer Tan (7441577), Gurjeet Kaur (85350), Sven H. Petersen (7441583), Amin M. S. Abdul Majid (7441586)   +7 more
core   +1 more source

A Hybrid Bioprinting–Microfabrication Approach to Controllable Multitype Spheroid Arrays for Modeling Tumor Heterogeneity

Advanced Healthcare Materials, EarlyView.
This work introduces a “cancer‐in‐a‐well” technology that recreates tumor heterogeneity in vitro using multitype spheroid arrays. Combining bioprinting/microdispensing with microstructured culture devices, the system improves drug screening and modeling of tumor complexity.
Simone Bonetti, Eva Clemente, Emanuela Mensà, Marco de Maria, Fulvia Farabegoli, Emanuela Saracino, Barbara Bortolani, Emanuela Marcelli, Renato Brandimarti, Dario de Biase, Giampaolo Zuccheri   +10 more
wiley   +1 more source

Figure_S4 – Supplemental material for BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil

, 2019
Supplemental material, Figure_S4 for BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil by Yi Jer Tan, Yeuan Ting Lee, Sven H. Petersen, Gurjeet Kaur, Koji Kono, Soo Choon Tan, Amin M. S. Abdul
Yeuan Ting Lee (7441580), Soo Choon Tan (1974859), Chern Ein Oon (7441589), Koji Kono (142779), Yi Jer Tan (7441577), Gurjeet Kaur (85350), Sven H. Petersen (7441583), Amin M. S. Abdul Majid (7441586)   +7 more
core   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

Figure_S3 – Supplemental material for BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil

, 2019
Supplemental material, Figure_S3 for BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil by Yi Jer Tan, Yeuan Ting Lee, Sven H. Petersen, Gurjeet Kaur, Koji Kono, Soo Choon Tan, Amin M. S. Abdul
Yeuan Ting Lee (7441580), Soo Choon Tan (1974859), Chern Ein Oon (7441589), Koji Kono (142779), Yi Jer Tan (7441577), Gurjeet Kaur (85350), Sven H. Petersen (7441583), Amin M. S. Abdul Majid (7441586)   +7 more
core   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

3-month versus 6-month adjuvant chemotherapy for patients with high-risk stage II and III colorectal cancer: 3-year follow-up of the SCOT non-inferiority RCT

Health Technology Assessment, 2019
Background: Oxaliplatin and fluoropyrimidine chemotherapy administered over 6 months is the standard adjuvant regimen for patients with high-risk stage II or III colorectal cancer.
Timothy Iveson, Kathleen A Boyd, Rachel S Kerr, Jose Robles-Zurita, Mark P Saunders, Andrew H Briggs, Jim Cassidy, Niels Henrik Hollander, Josep Tabernero, Andrew Haydon, Bengt Glimelius, Andrea Harkin, Karen Allan, John McQueen, Sarah Pearson, Ashita Waterston, Louise Medley, Charles Wilson, Richard Ellis, Sharadah Essapen, Amandeep S Dhadda, Mark Harrison, Stephen Falk, Sherif Raouf, Charlotte Rees, Rene K Olesen, David Propper, John Bridgewater, Ashraf Azzabi, David Farrugia, Andrew Webb, David Cunningham, Tamas Hickish, Andrew Weaver, Simon Gollins, Harpreet Wasan, James Paul   +36 more
doaj   +1 more source

Desenvolvimento e avaliação biofarmacêutica de sistemas coloidais como carreadores para a administração ocular do agente antitumoral 5-fluorouracil [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-graduação em FarmáciaO potencial das nanopartículas poliméricas em aumentar as oportunidades de absorção corneal após a administração tópica na ...
Reus, Márcia
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