Gankyrin‐Protein Interactions in GI Cancers: A Novel Target of New Therapeutics
Chronic Diseases and Translational Medicine, EarlyView.ABSTRACT Gankyrin (PSMD10) is a 25 kDa oncogenic protein and regulatory subunit of the 26S proteasome, characterized by a sevenfold ankyrin repeat domain. Gankyrin is overexpressed in various malignancies, particularly gastrointestinal (GI) cancers. Gankyrin contributes to tumorigenesis by modulating key signaling pathways and engaging in oncogenic ...
Shuang Li +4 more
wiley +1 more source
Intrahepatic arterial infusion of combination of mitomycin-C and 5-fluorouracil in treatment of primary and metastatic liver carcinoma [PDF]
, 1977 N. C. Misra +3 more
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Chemistry–Methods, EarlyView.Strong external magnetic fields can keep paramagnetic porous particles static without falling down while immersed in a liquid medium, and the strength of the required magnetic field, controlled indirectly by the distance to a permanent magnet, correlates with the mass of adsorbate captured, giving rise to a new technique for quantifying adsorption ...
Rubén Pérez‐Aguirre +5 more
wiley +1 more source
Plasma levels of 5‐fluorouracil after oral and intravenous administration in cancer patients. [PDF]
, 1979 RE Finch, M.R. Bending, AF Lant
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Clinical Pharmacology &Therapeutics, EarlyView.This study assessed the use of 35 pharmacogenomic (PGx) medications listed in the Royal College of Pathologists of Australasia (RCPA) guideline, estimated the potential costs of subsidizing PGx testing in Australia, and predicted related prescribing changes.
Bella D. Ianni +3 more
wiley +1 more source
An analysis of a multiple‐drug program in the treatment of patients with advanced breast cancer utilizing 5‐fluorouracil, cyclophosphamide, and prednisone with or without vincristine [PDF]
, 1975 David L. Ahmann +7 more
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UGT1A1 and Sacituzumab Govitecan Toxicity: A Systematic Review and Meta‐Analysis
Clinical Pharmacology &Therapeutics, EarlyView.Sacituzumab govitecan (SG), a humanized antibody‐drug conjugate, enables intra‐tumor delivery of SN‐38, the active metabolite of irinotecan, with the aim of increasing efficacy. SN‐38 is predominantly inactivated by the polymorphically expressed uridine diphosphate glucuronosyltransferase 1A1 (UGT1AA) where reduced activity can lead to toxicity.
Cinzia Dello Russo +4 more
wiley +1 more source
Anticancer efficacy of albumin nanoparticles co-loaded with silver nanoparticles and 5FU in animal model of colon cancer. [PDF]
Sci RepDehghani M +4 more
europepmc +1 more source
Low dose chemotherapy of metastatic breast cancer with cyclophosphamide, adriamycin, methotrexate, 5-fluorouracil (CAMF) versus sequential cyclophosphamide, methotrexate, 5-fluorouracil (CMF) and adriamycin [PDF]
, 1979 Richard H. Creech +4 more
openalex +1 more source