Results 41 to 50 of about 283,224 (387)

Anti epidermal growth factor receptor therapy in small bowel adenocarcinoma [PDF]

, 2018
Rationale:Small bowel adenocarcinoma (SBA) is an uncommon gastrointestinal cancer, thus limited data about treatment for advanced disease are available.
Anselmi, Elisabetta, Falcone, Rosa, Filetti, Marco, Marchetti, Paolo, Roberto, Michela   +4 more
core   +1 more source

Preoperative chemoradiation in locally advanced rectal cancer: A comparison of bolus 5-fluorouracil/leucovorin and capecitabine

The Saudi Journal of Gastroenterology, 2014
Purpose: To compare the acute toxicities, pathologic response, surgical margins, downstaging, local control, disease-free survival (DFS), and overall survival (OS) in locally advanced rectal cancer patients with preoperative radiotherapy (RT) with either
Adnan Yoney, Levent Isikli
doaj   +1 more source

Neoadjuvant Modified FOLFOX6 With or Without Radiation Versus Fluorouracil Plus Radiation for Locally Advanced Rectal Cancer: Final Results of the Chinese FOWARC Trial

Journal of Clinical Oncology, 2019
PURPOSE In the multicenter, open-label, phase III FOWARC trial, modified infusional fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus radiotherapy resulted in a higher pathologic complete response rate than fluorouracil plus radiotherapy in ...
Yanhong Deng, P. Chi, P. Lan, Lei Wang, Weiqing Chen, L. Cui, Daoda Chen, Jie Cao, Hongbo Wei, Xiang Peng, Zonghai Huang, Guanfu Cai, R. Zhao, Zhongcheng Huang, Lin Xu, Hongfeng Zhou, Yisheng Wei, Hao Zhang, Jian Zheng, Yan Huang, Zhi-yang Zhou, Yue Cai, L. Kang, Meijin Huang, Xiaojian Wu, J. Peng, D. Ren, Jianping Wang   +27 more
semanticscholar   +1 more source

Xanthine Oxidase Inhibitor, Febuxostat Is Effective against 5-Fluorouracil-Induced Parotid Salivary Gland Injury in Rats Via Inhibition of Oxidative Stress, Inflammation and Targeting TRPC1/CHOP Signalling Pathway

Pharmaceuticals, 2022
The current research aimed to examine the ameliorative role of febuxostat (FEB), a highly potent xanthine oxidase inhibitor, against 5-fluorouracil (5-FU)-induced parotid salivary gland damage in rats, as FEB is a pleiotropic drug that has multiple ...
Walaa Yehia Abdelzaher, Mohamed A. Nassan, Sabreen Mahmoud Ahmed, Nermeen N. Welson, Gaber El-Saber Batiha, Hanaa Mohamed Khalaf   +5 more
doaj   +1 more source

Synthesis of 5-Fluorouracil Cocrystals with Novel Organic Acids as Coformers and Anticancer Evaluation against HCT-116 Colorectal Cell Lines

, 2020
5-Fluorouracil (5-FU) being a mainstream anticancer drug is under keen and detailed investigation for prodrugs formulations in order to minimize the associated side effects.
Farhat Jubeen, Aisha Liaqat, Fiza Amjad, M. Sultan, Sania Zafar Iqbal, I. Sajid, M. B. Niazi, Farooq Sher   +7 more
semanticscholar   +1 more source

Phase II trial of preoperative radiochemotherapy with concurrent bevacizumab, capecitabine and oxaliplatin in patients with locally advanced rectal cancer [PDF]

, 2013
Background: Preoperative radiochemotherapy (RCT) with 5-FU or capecitabine is the standard of care for patients with locally advanced rectal cancer (LARC). Preoperative RCT achieves pathological complete response rates (pCR) of 10-15%.
Arnold, Dirk, Dellas, Kathrin, Dunst, Jürgen, Engel, Erik, Höhler, Thomas, Reese, Thomas, Richter, Michael, Rödel, Claus, Wagner, Wolfgang, Würschmidt, Florian   +9 more
core   +1 more source

Fluorouracil Supplemented With Oxaliplatin or Irinotecan for Solid Tumors: Indications From Clinical Characteristics and Health Outcomes of Patients

Frontiers in Oncology, 2020
Fluorouracil combined with oxaliplatin (FOLFOX) and fluorouracil combined with irinotecan (FOLFIRI) are both first-line clinical chemotherapy regimens. However, clinicians' selection of FOLFIRI or FOLFOX medication regimens and their effects on patients'
Zhao Qingwei, Zhao Qingwei, Hong Dongsheng, Lv Duo, Lv Duo, Wang Youlei, Yu Songxia, Ye Ziqi, Li Lanjuan   +8 more
doaj   +1 more source

Increased response of oxaliplatin or irinotecan on chemosensitivity to 5-fluorouracil in patients with colorectal cancer [PDF]

Korean Journal of Clinical Oncology, 2014
Purpose: Five-fluorouracil (5-FU) is the basement drug of chemotherapy in patients with colorectal cancer. Recently, 5-FU and oxaliplatin or irinotecan is to be used by merging.
Se Na Cho, Kyung Jong Kim
doaj   +1 more source

Bevacizumab plus Irinotecan-Based Regimens in the Treatment of Metastatic Colorectal Cancer [PDF]

, 2010
Objectives: Bevacizumab is a monoclonal antibody that directly inhibits vascular endothelial growth factor, a key regulator of angiogenesis. Bevacizumab significantly improves progression-free and/or overall survival in metastatic colorectal cancer in ...
Heinemann, Volker, Hoff, Paulo M.
core   +1 more source

COMPARISON OF THE ANTIEMETIC EFFECTIVENESS BETWEEN GRANISETRON AND DEXAMETHASONE WITH ONDANSETRON AND DEXAMETHASONE IN ACUTE-PHASE CHEMOTHERAPY PATIENTS

Folia Medica Indonesiana, 2017
Nausea and vomiting may occur in patients receiving chemotherapy, a condition referred to as chemotherapy-induced nausea and vomiting. The provision of combined dexamethasone and ondansetron or granisetron is the therapeutic management of acute phase ...
Ria Fitrah Arfiani, Dwi Hari Susilo, Budi Suprapti   +2 more
doaj   +1 more source