Results 31 to 40 of about 105,140 (274)

Study on anti-inflammatory and immunomodulatory effects of fluoxetine in rat models of inflammation

European Journal of Inflammation, 2015
The aim of the present study was to evaluate the anti-inflammatory effect of fluoxetine in carrageenan- and lipoplysaccharide-induced models of inflammation by investigating the changes in serum levels of pro-inflammatory cytokine TNF-α and anti ...
Ilia Kostadinov, Delian Delev, Atanaska Petrova, Irina Stanimirova, Krassimira Draganova, Peter Kruzliak, Ivanka Kostadinova, Marianna Murdjeva   +7 more
doaj   +1 more source

Using a new high-throughput video-tracking platform to assess behavioural changes in Daphnia magna exposed to neuro-active drugs [PDF]

, 2019
© 2019. ElsevierOne of the major challenges that faces today regulatory risk assessment is to speed up the way of assessing threshold sublethal detrimental effects of existing and new chemical products.
Barata Martí, Carlos, Blasco Gutiérrez, Víctor, Martínez Jerónimo, Fernando, Moreno-Noguer, Francesc, Pestana, Joao, Porta Pleite, Josep Maria, Raldúa Pérez, Demetrio José, Simão, Fátima C.P., Soarez, Amadeu   +8 more
core   +1 more source

The Possible Role of Fluoxetine in Adenomyosis: An Animal Experiment with Clinical Correlations [PDF]

Journal of Clinical and Diagnostic Research, 2013
Introduction: Fluoxetine is a commonly prescribed drug which is used in the psychiatric practice and adenomyosis is a common medical problem in women of the reproductive age group.
Parama Sengupta, Abhishek Sharma, Gautameswar Mazumdar, Indranil Banerjee, Santanu K Tripathi, Chiranjib Bagchi, Nina Das   +6 more
doaj   +1 more source

Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise.

Brain Research Bulletin, 2018
Of wide interest for health is the relation existing between depression, a very common psychological illness, accompanied by anxiety and reduced ability to concentrate, and adult neurogenesis.
L. Micheli, Manuela Ceccarelli, Giorgio D’Andrea, F. Tirone   +3 more
semanticscholar   +1 more source

Fluoxetine ameliorates dysbiosis in a depression model induced by chronic unpredicted mild stress in mice

International Journal of Medical Sciences, 2019
Background: Accumulating evidence has shown that neuropsychiatric disorders are associated with gut microbiota through the gut-brain axis. However, the effects of antidepressant treatment on gut microbiota are rarely studied.
Lijuan Sun, Haohao Zhang, Ying Cao, Chenchen Wang, Changhai Zhao, Huaning Wang, G. Cui, Meixia Wang, Yan Pan, Yupeng Shi, Y. Nie   +10 more
semanticscholar   +1 more source

Fluoxetine-induced Hypotension: A Case Report

Pharmaceutical and Biomedical Research, 2023
Fluoxetine is a Selective Serotonin Reuptake Inhibitor (SSRI) that exerts its anti-depressive effect by blocking the presynaptic reuptake of the neurotransmitter serotonin, 5-hydroxytryptamine (5-HT).
Seyed Hamzeh Hosseini, Neda Zamani, Amirhossein Ahmadi   +2 more
doaj  

A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. [PDF]

, 2018
We describe here the results from the testing of a small molecule first-in-class apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, A03, that increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic ...
Bai, Dongsheng, Bilousova, Tina, Bredesen, Dale E, Campagna, Jesus, Cole, Gregory, Elias, Chris Jean, Hatami, Asa, Jagodzinska, Barbara, John, Varghese, Jun, Michael, Jung, Michael E, LaDu, Mary Jo, Pham, Johnny, Spilman, Patricia, Zhu, Chunni   +14 more
core   +3 more sources

Morphological aspects of dentin-pulp complex development in the offspring of rats treated with fluoxetine during pregnancy

Brazilian Journal of Oral Sciences, 2015
Aim: To evaluate the morphological aspects of coronal dentinogenesis in the first molars of 1- and 5-day-old rats whose mothers were treated with fluoxetine hydrochloride during pregnancy.
Isabela Maria de Albuquerque Santiago, Luciana Silva Regueira, Priscylla Gonçalves Correia, Robério José Barbosa de Alcântara, Joaquim Evêncio Neto, Liriane Baratella-Evêncio   +5 more
doaj   +1 more source

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
core   +1 more source

Fluoxetine-induced alteration of murine gut microbial community structure: evidence for a microbial endocrinology-based mechanism of action responsible for fluoxetine-induced side effects

PeerJ, 2019
Background Depression and major depressive disorder affect 25% of the population. First line treatment utilizing selective serotonin reuptake inhibitors (SSRIs) have met with limited success due to well-recognized negative side effects which include ...
M. Lyte, Karrie Daniels, S. Schmitz-Esser   +2 more
semanticscholar   +1 more source