Results 31 to 40 of about 87,517 (311)

Quantitative cross-species extrapolation between humans and fish: The case of the anti-depressant fluoxetine [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Fish are an important model for the pharmacological and toxicological characterization of human pharmaceuticals in drug discovery, drug safety assessment and ...
ABA Boxall, AC Altamura, AC Johnson, Anna de Polo, BJ Ring, C Charlier, C Hiemke, C Lillesaar, C Maximino, CA LaLone, CB Eap, D Baldwin, D Kokel, DB Huggett, DJ Caldwell, DS Baldwin, ED Levin, EJ Perkins, FM McRobb, G Jannuzzi, GG Gould, Grace H. Panter, GT Ankley, J Cachat, J Klooster, J Kristensen, J Lundmark, J Rihel, J Rihel, JA Mennigen, JD Amsterdam, JG Kohlert, Jodi Pawluski, John P. Sumpter, JP Berninger, JP Seiler, JP Sumpter, JP Sumpter, JT Pittman, JV Goldstone, K Kuemmerer, KD Oakes, L Bjerkenstedt, L Fjordside, L Gunnarsson, L Ibrahim, L Margiotta-Casaluci, LD Ellis, Luigi Margiotta-Casaluci, M Rand-Weaver, M Schulz, M Sundvik, M Wolman, MA Lopez-Patino, Mariann Rand-Weaver, Matthew J. Winter, MC Celander, MG Scordo, MJ Airhart, MJ Owens, MJ Winter, MS Lipsky, MW Kelly, PD Anderson, RF Bergstrom, RJ Egan, Rob I. Cumming, RY Wong, SC Baraban, SC Dulawa, SH Preskorn, SH Preskorn, Stewart F. Owen, TJ Runnalls, TR Norman, TW Valenti Jr, TW Valenti Jr, WJAJ Smeets, YH Zhang, YJ Kim, Z Bencan   +80 more
core   +3 more sources

Anxiolytic profile of fluoxetine as monitored following repeated administration in animal rat model of chronic mild stress

Saudi Pharmaceutical Journal, 2016
Background: Fluoxetine, a selective serotonin re-uptake inhibitor (SSRI), has been proposed to be more effective as an antidepressive drug as compared to other SSRIs.
Muhammad Farhan, Darakshan Jabeen Haleem
doaj   +1 more source

Dopamine receptor agonist rotigotine-loaded microspheres ameliorates sexual function deteriorated by fluoxetine in depression rats

ASN Neuro, 2021
Low dopamine levels may cause depressive symptoms. Dopamine is also involved in sexual behavior. Rotigotine is a nonergolinic dopamine agonist. Fluoxetine, an antidepressant that acts as a selective serotonin (5-HT) reuptake inhibitor, may cause moderate
Wenqian Wang, Ce Zhang, Yiqian Fan, Shumin Yue, Yunqi Yang, Rongxia Liu, Leiming Zhang, Tian Wang, Fenghua Fu   +8 more
doaj   +1 more source

An adolescent girl with signs and symptoms of anaphylaxis and negative immunologic workup: a case report. [PDF]

, 2020
BackgroundThe increasing incidence of allergies and allergic reactions among children and adults has become a major public health concern. The etiology of allergic reactions can often be confirmed based on a detailed history and supportive testing ...
Bauer, Maureen, Frank, Guido KW, Green, Sarah, Hicks, Allison, Hilsendager, Chelsea   +4 more
core  

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
core   +1 more source

De‐Saturation of Single‐Atom Copper Catalysts for Accelerating Propargylic Substitution Reactions

Advanced Materials, EarlyView.
De‐saturation of copper‐based single‐atom catalysts (De‐sat SACs) are realized by a KOH‐mediated Joule thermal shock strategy. Benefiting from the under‐saturation coordination environment of single‐atom Cu center, De‐sat Cu SACs exhibit remarkable catalytic activity in propargylic substitution reactions, tolerating a broad range of nucleophiles (N–, C–
Qilong Cai, Yang Meng, Chao Wu, Wenjia Qu, Qiang Wang, Tan Li, Chengyi Liu, Jinxing Chen, Huihui Lin, Qian He, Yafei Zhao, Shibo Xi, Jiong Lu   +12 more
wiley   +1 more source

Towards a revanchist British rural in post‐COVID times? A challenge to those seeking a good countryside

The Geographical Journal, EarlyView., 2023
Abstract The last decade has seen at least three still ongoing shocks impact strongly on rural Britain: Brexit, COVID‐19 and the Russia–Ukraine war. This paper introduces all three of these after setting the scene prior to the 2016 Brexit vote by first summarising the seeming shift across rural Britain from productivism to post‐productivism in the ...
Keith Halfacree
wiley   +1 more source

Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway

Journal of Neuroinflammation, 2018
Background Neuroinflammation is closely associated with functional outcome in subarachnoid hemorrhage (SAH) patients. Our recent study demonstrated that fluoxetine inhibited NLRP3 inflammasome activation and attenuated necrotic cell death in early brain ...
Fu-yi Liu, Jing Cai, Chun Wang, Wu Ruan, Guo-ping Guan, Hai-zhou Pan, Jian-ru Li, Cong Qian, Jing-sen Chen, Lin Wang, Gao Chen   +10 more
doaj   +1 more source

Galanin (1-15) enhances the behavioral effects of fluoxetine in the forced swimming test: a new therapeutic strategy against depression [PDF]

, 2017
The selective serotonergic (5- HT) reuptake inhibitors, including Fluoxetine (FLX), are the most commonly used for treatment of major depression. However, the understanding of the mechanism of action of FLX beyond its effect of elevating 5-HT is limited.
Borroto-Escuela, Dasiel O., Díaz-Cabiale, Zaida, Flores-Burgess, Antonio, Fuxe, Kjell, Gago, Belén, LuisSantínPhDd, Mengod Los Arcos, Guadalupe, Millón, Carmelo, Narváez, José Angel, Narváez, Manuel   +9 more
core   +2 more sources

Time‐Dependent Therapeutic Effect of S‐Ketamine on PTSD Mediated by VTA‐OFC Dopaminergic Neurocircuit

Advanced Science, EarlyView.
This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang, Lei Liu, Jinghao Wang, Jiannan Li, Huiming Li, Rui Wang, Hui Wang, Min Wang, Quanying Liu, Zhongmin Fan, Yunyun Zhang, Xinxin Zhang, Dan Wang, Sa Wang, Rou Xue, Jindong Mao, Min Cai, Pengfei Wei, Hailong Dong, Yumei Wu, Guangchao Zhao   +20 more
wiley   +1 more source