Results 111 to 120 of about 18,513 (243)
Innate Immunity Never “NODs” Off: NLRs Regulate the Host Anti‐Viral Immune Response
Immunological Reviews, Volume 330, Issue 1, March 2025.ABSTRACT A robust innate immune response is essential in combating viral pathogens. However, it is equally critical to quell overzealous immune signaling to limit collateral damage and enable inflammation resolution. Pattern recognition receptors are critical regulators of these processes.
Mackenzie K. Woolls +5 more
wiley +1 more source
Extracellular vesicles promote the infection and pathogenicity of Japanese encephalitis virus
Journal of Extracellular Vesicles, Volume 14, Issue 1, January 2025.Abstract Japanese encephalitis virus (JEV) is a neurotropic zoonotic pathogen that poses a serious threat to public health. Currently, there is no specific therapeutic agent available for JEV infection, primarily due to the complexity of its infection mechanism and pathogenesis.
Junyao Xiong +14 more
wiley +1 more source
Veterinary Medicine and Science, Volume 11, Issue 1, January 2025.The figure shows the effects (increasing upward arrow or decreasing downward arrow) the most common host traits, landscape attributes, climatic features and anthropogenic variables recorded in the review had on the infection and transmission of directly transmitted virus to mammals.
María del Carmen Villalobos‐Segura +3 more
wiley +1 more source
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity
Immunological Reviews, Volume 329, Issue 1, January 2025.ABSTRACT The sensing of nucleic acids by DEAD/H‐box helicases, specifically retinoic acid‐inducible gene I (RIG‐I) and melanoma differentiation‐associated protein 5 (MDA5), plays a critical role in inducing antiviral immunity following infection. However, this DEAD/H‐box helicase family includes many additional proteins whose immune functions have not ...
Michael Parthun +2 more
wiley +1 more source
Epitope Mapping of Senecavirus A 3A Protein Using Monoclonal Antibodies
Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.Senecavirus A (SVA), an emerging pathogen causing vesicular disease in pigs, poses a significant threat to the swine industry. The nonstructural protein 3A of SVA plays an essential role in the viral replication cycle. In this study, we immunized mice with the prepared SVA 3A protein and produced two monoclonal antibodies (mAbs), AG4 and 2F3.
Liang Meng +9 more
wiley +1 more source
Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.Seneca Valley virus (SVV) infection has recently disseminated across pig farms in Canada, America, and China. The SVV has been identified in humans, rodents, and houseflies. Although cross‐species transmission events may lead to limited subsequent transmission, sustained outbreaks have been observed in new mammalian hosts.
Ziliang Qin +14 more
wiley +1 more source
Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.Porcine Reproductive and Respiratory Syndrome (PRRS) and Pseudorabies (PR) are highly contagious diseases caused by Porcine Reproductive and Respiratory Syndrome virus (PRRSV) and Pseudorabies virus (PRV). Due to the limited protective ability of currently commercialized vaccines against NADC30‐like PRRSV and PRV variants, the pathological damage ...
Ruhai Guo +13 more
wiley +1 more source
Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.African swine fever (ASF) is one of the most devastating diseases affecting the global pig industry. Therefore, the development of safe and effective vaccines is crucial in combating the virus. The AVAC ASF LIVE vaccine, produced from an attenuated genotype II ASF virus (ASFV) strain with the deletion of six MGF genes and cultured in a Diep’s ...
Nguyen Van Diep +8 more
wiley +1 more source
Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.Information on the circulation of foot‐and‐mouth disease (FMD) in Western Syria is very limited. It is known that the country is affected by a prolonged humanitarian crisis that may certainly have contributed to such lack of information and the latest available data date back to 2002.
Tiziana Trogu +15 more
wiley +1 more source
Development of tailored real-time RT-PCR assays for the detection and differentiation of serotype O, A and Asia-1 foot-and-mouth disease virus lineages circulating in the Middle East [PDF]
, 2014 Rapid and accurate diagnosis is essential for effective control of foot-and-mouth disease (FMD). In countries where FMD is endemic, identification of the serotypes of the causative virus strains is important for vaccine selection and tracing the source ...
Belsham, Graham +5 more
core +1 more source