Results 81 to 90 of about 7,295 (180)

Effective inhibition of foot-and-mouth disease virus (FMDV) replication in vitro by vector-delivered microRNAs targeting the 3D gene

Virology Journal, 2011
Background Foot-and-mouth disease virus (FMDV) causes an economically important and highly contagious disease of cloven-hoofed animals. RNAi triggered by small RNA molecules, including siRNAs and miRNAs, offers a new approach for controlling viral ...
Cai Xuepeng, Lin Tong, Shao Junjun, Cong Guozheng, Zhang Guofeng, Luo Jihuai, Gao Shandian, Du Junzheng, Chang Huiyun   +8 more
doaj   +1 more source

Prolyl endopeptidase is a multifunctional host factor required for FMDV infection

Cellular and Molecular Life Sciences
Foot-and-mouth disease virus (FMDV) poses a significant global threat to livestock production, underscoring the urgent need for a deeper understanding of virus-host interactions to develop effective prevention strategies. In this study, we identify prolyl endopeptidase (PREP) as a critical host factor in FMDV infection.
Kun Ma, Rongzeng Hao, Tianran Liu, Yi Ru, Tao Feng, Xiaolan Qi, Yuzhe Wang, Bingzhou Lu, Sen Wu, Dan Li, Ran Zhang, Yaofeng Zhao, Haixue Zheng   +12 more
openaire   +3 more sources

A Fluorescent Immunochromatography Test Strip for the Rapid Identification of SVV and FMDV

Transboundary and Emerging Diseases
Seneca Valley virus (SVV) and foot‐and‐mouth disease virus (FMDV) belong to the Picornaviridae family, which can cause similar symptoms. After infection, pigs will develop fever; loss of appetite; blister lesions on the skin and mucous membrane of the mouth, nose, and hoof; and other similar diseases, and the spread is very fast, causing major economic
Liuyue Yang, Chengfei Li, Xinghua Chen, Kun Li, Zengjun Lu, Xiangmin Li, Meilin Jin, Ping Qian   +7 more
openaire   +2 more sources

Interferon-stimulated gene MCL1 inhibits foot-and-mouth disease virus replication by modulating mitochondrial dynamics and autophagy

Journal of Virology
Interferons (IFNs) and the IFN-stimulated genes (ISGs) that they induce are effective in reducing the replication of foot and mouth disease virus (FMDV).
Aishwarya Mogulothu, Danielle Hickman, Sarah Attreed, Paul Azzinaro, Monica Rodriguez-Calzada, Meike Dittmann, Teresa de los Santos, Steven Szczepanek, Gisselle N. Medina   +8 more
doaj   +1 more source

Universal amplification and sequencing of foot-and-mouth disease virus complete genomes using nanopore technology

BMC Genomics
Background Foot-and-mouth disease virus (FMDV) is capable of causing explosive outbreaks among domestic and wild cloven-hoofed animals. Genomic characterisation of FMDV is a crucial component of disease control enabling accurate tracing of disease ...
Andrew E. Shaw, Kebaneilwe Lebani, Lina González Gordon, Ugonna E. Ihearahu, Jemma Wadsworth, Hayley M. Hicks, Noemi Polo, Graham Freimanis, Dennis Muhanguzi, Chandana Tennakoon, Richard J. Orton, Nick J. Knowles, Antonello Di Nardo, Ryan A. Waters, Barend MdeC Bronsvoort, Donald P. King   +15 more
doaj   +1 more source

Phospholipase PLA2G16 Accelerates the Host Interferon Signaling Pathway Response to FMDV

Viruses
PLA2G16 is a member of the phospholipase A2 family that catalyzes the generation of lysophosphatidic acids (LPAs) and free fatty acids (FFAs) from phosphatidic acid. Previously, PLA2G16 was found to be a host factor for picornaviruses. Here, we discovered that the Foot-and-Mouth Disease Virus (FMDV) infection led to an elevation in PLA2G16 ...
Bingjie Sun, Xiaodong Qin, Taoqing Zhang, Sujie Dong, Yinbo Ye, Changying Wang, Yan Zhang, Rongzeng Hao, Yi Ru, Hong Tian, Haixue Zheng   +10 more
openaire   +3 more sources

Virulence and Immune Evasion Strategies of FMDV: Implications for Vaccine Design

Vaccines
Foot-and-mouth disease (FMD) is globally recognized as a highly economically devastating and prioritized viral disease affecting livestock. Vaccination remains a crucial preventive measure against FMD. The improvement of current vaccine platforms could help control outbreaks, leading to the potential eradication of the disease.
Gisselle N. Medina, Fayna Diaz San Segundo   +1 more
openaire   +3 more sources

Differential mosaicism of recombinant foot-and-mouth disease viruses resulting from heterologous superinfection of cattle

Journal of Virology
Evidence from both field and experimental studies suggests that recombination is a common feature in the evolution of foot-and-mouth disease virus (FMDV).
Carolina Stenfeldt, Ian H. Fish, Monica Rodriguez-Calzada, Gisselle Medina, Juergen A. Richt, Jonathan Arzt   +5 more
doaj   +1 more source

CD44 mediates the internalization of foot-and-mouth disease virus through macropinocytosis

Veterinary Research
Foot-and-mouth disease virus (FMDV), a member of the Picornavirus family, poses a significant threat to global animal husbandry. While it is known that macropinocytosis plays a crucial role in the entry of FMDV into cells, the specific cellular proteins ...
Xuefei Wang, Hu Dong, Jin’en Wu, Yun Zhang, Shiqi Sun, Huichen Guo   +5 more
doaj   +1 more source

Structure, mechanism and specificity of FMDV 3C protease [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2005
S. Curry, J. Birtley, S. Knox, A. Jaulent, P. Brick, R. Leatherbarrow   +5 more
openaire   +1 more source