Results 111 to 120 of about 22,945 (246)

Cow's Milk Positively Impacts Bone Formation by Regulating the Osteocalcin Pathway Compared to Transgenic and Non‐Transgenic Soy‐Based Beverages in BALB/c Mice

Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
Comparison of the effects of cow's milk and transgenic soy‐based beverages on bone health in BALB/c mice. Cow's milk promoted higher trabecular density; improved bone structure; and increased osteocalcin, calcium, and phosphorus levels. The non‐transgenic soy beverage led to reduced cortical thickness and increased diaphysis diameter, while the ...
Eduarda Pires Costa, Mariáurea Matias Sarandy, Amanda Alves Lozi, Maria Tatiana Soares Martins, Patricia da Silva Mattosinhos, Manoela Maciel dos Santos Dias, Sergio Luis P. Matta, Romulo Dias Novaes, Reggiani Vilela Gonçalves   +8 more
wiley   +1 more source

Molecular dynamics simulations show how the FMRP Ile304Asn mutation destabilizes the KH2 domain structure and affects its function [PDF]

, 2013
Mutations or deletions of FMRP, involved in the regulation of mRNA metabolism in brain, lead to the Fragile X syndrome (FXS), the most frequent form of inherited intellectual disability.
Achsel, T, Bagni, C, Di Marino, D, Falconi, M, Lacoux, C   +4 more
core   +2 more sources

SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members [PDF]

, 2022
Olivier Binda, Franceline Juillard, Julia Novion Ducassou, Constance Kleijwegt, Geneviève Paris, Andréanne Didillon, Faouzi Baklouti, Armelle Corpet, Yohann Couté, Jocelyn Côté, Patrick Lomonte   +10 more
openalex   +1 more source

RNF219 RING Finger Domain Mutants Drive Phase Separation to Encapsulate CCR4‐NOT and Promote Cell Proliferation

Cell Proliferation, Volume 59, Issue 1, January 2026.
Mutations in the RING finger domain (C3HC4) of RNF219 promote the formation of RNF219 condensates, which are able to encapsulate the CCR4‐NOT complex. These RNF219Mut‐CCR4‐NOT condensates reduce the deacetylation activity of the CCR4‐NOT complex and induce cell proliferation.
Chen Chen, Chenghao Guo, Ke Fang, Chengqi Lin, Zhuojuan Luo   +4 more
wiley   +1 more source

FMRP regulates postnatal neuronal migration via MAP1B

eLife
The fragile X syndrome (FXS) represents the most prevalent form of inherited intellectual disability and is the first monogenic cause of autism spectrum disorder. FXS results from the absence of the RNA-binding protein FMRP (fragile X messenger ribonucleoprotein).
Messaoudi, Salima, Allam, Ada, Stoufflet, Julie, Paillard, Theo, Le Ven, Anaïs, Fouquet, Coralie, Doulazmi, Mohamed, Trembleau, Alain, Caille, Isabelle   +8 more
openaire   +4 more sources

Behavioral training rescues motor deficits in Cyfip1 haploinsufficiency mouse model of Autism Spectrum Disorders [PDF]

, 2019
Deletions in the 15q11.2 region of the human genome are associated with neurobehavioral deficits, and motor development delay, as well as in some cases, symptoms of autism or schizophrenia.
Adam Ranson, Ellen Cross, Fangli Chen, Monika Sledziowska, Shireene Kalbassi, Sophie Waldron, Stéphane J. Baudouin, Sven O. Bachmann   +7 more
core   +4 more sources

Dissociation of the mTOR Protein Interaction Network Following Neuronal Activation Is Altered by Shank3 Mutation

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Neurons encode activity through precise, stimulus‐dependent rearrangements of protein interaction networks, including the mTOR signaling cascade. Using multiplex co‐immunoprecipitation in primary cortical neurons, we show that IGF1, glutamate, and homeostatic up‐ or down‐scaling with Tetrodotoxin (TTX) or Bicuculline (BIC), respectively, each induce ...
Devin T. Wehle, Emily A. Brown, Vera Stamenkovic, Breann Gniffen, Felicia M. Harsh, Stephen E. P. Smith   +5 more
wiley   +1 more source

Le syndrome de l'X fragile : Une protéine absente et 1001 ARNm déboussolés [PDF]

, 2006
Le syndrome du X fragile, première cause de retard mental héréditaire, est une maladie monogénique liée au chromosome X. Le syndrome est causé par l’inactivation du gène Fragile Mental Retardation 1(FMR1) entraînant l’absence de la protéine FMRP dont le ...
Davidovic, Laetitia, De Koninck, Paul, Gravel, Maud, Khandjian, Edward W. Miky, Tremblay, Sandra   +4 more
core   +1 more source

Immune‐Related Protein and Non‐Coding RNA Cargo of Extracellular Vesicles Participate in the Chronic Inflammation Induced by HIV Infection

Journal of Extracellular Biology, Volume 4, Issue 12, December 2025.
ABSTRACT Extracellular vesicles (EVs) promote intercellular communication, playing a key role in the secondary immune‐related pathologies driven by chronic inflammation in people living with HIV (PLWH). To identify molecular components within large EVs (lEVs) from PLWH's plasma that may influence immune function and contribute to the pathological ...
Humberto Doriguêtto Gravina, Ricardo Cardoso Castro, Ana Margarida Gonçalves, Julia Oliveira Lima, Fabrícia Heloísa Cavicchioli Sugiyama, Brenda Cavalin Moreira, Mateus da Silva Matias Antunes, Caroline Fontanari, Valdes Roberto Bollela, Yann Yves Lamarre, Fausto Almeida, Simone Kashima, Margarida Saraiva, Nuno Osório, Fabiani Gai Frantz   +14 more
wiley   +1 more source

Synaptic Activity Regulated mRNA-Silencing Foci for the Fine Tuning of Local Protein Synthesis at the Synapse [PDF]

, 2012
The regulated synthesis of specific proteins at the synapse is important for neuron plasticity, and several localized mRNAs are translated upon specific stimulus. Repression of mRNA translation is linked to the formation of mRNA-silencing foci, including
Boccaccio, Graciela Lidia, Habif, Martin, Luchelli, Luciana, Pascual, Malena Lucía   +3 more
core   +2 more sources