ESCRT-III Membrane Trafficking Misregulation Contributes To Fragile X Syndrome Synaptic Defects
Scientific Reports, 2017 The leading cause of heritable intellectual disability (ID) and autism spectrum disorders (ASD), Fragile X syndrome (FXS), is caused by loss of the mRNA-binding translational suppressor Fragile X Mental Retardation Protein (FMRP).
Dominic J. Vita, Kendal Broadie
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Cell Reports, 2015 Subcellular targeting and local translation of mRNAs are critical for axon development. However, the precise local control of mRNA translation requires investigation.
Bin Wang +8 more
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ALS-FUS mutation affects the activities of HuD/ELAVL4 and FMRP leading to axon phenotypes in motoneurons [PDF]
, 2020 Maria Giovanna Garone +11 more
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A rapid and dynamic role for FMRP in the plasticity of adult neurons [PDF]
, 2023 Daniel G. Gundermann +2 more
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FMRP: a new chapter with chromatin [PDF]
Protein & Cell, 2014 He, Qingzhong, Ge, Wei
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BDNF Regulates the Expression of Fragile X Mental Retardation Protein mRNA in the Hippocampus
Neurobiology of Disease, 2002 Both fragile X mental retardation protein (FMRP) and brain-derived neurotrophic factor (BDNF) are implicated in the maturation of neurons and in the higher cognitive functions.
Maija Castrén +7 more
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Network assisted analysis to reveal the genetic basis of autism
, 2015 While studies show that autism is highly heritable, the nature of the genetic basis of this disorder remains illusive. Based on the idea that highly correlated genes are functionally interrelated and more likely to affect risk, we develop a novel ...
Lei, Jing, Liu, Li, Roeder, Kathryn
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Toward peptide-based protein replacement in fragile X syndrome: Evaluating the N-tat strategy
Medicine in Drug DiscoveryFragile X syndrome (FXS), a leading inherited cause of intellectual disability and autism, arises from loss of the RNA-binding protein FMRP and consequent dysregulation of synaptic mRNA translation.
Oliver A. Kent
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Treatment of Fragile X Syndrome with Cannabidiol: A Case Series Study and Brief Review of the Literature. [PDF]
, 2019 Fragile X syndrome (FXS) is an X-linked dominant disorder caused by a mutation in the fragile X mental retardation 1 gene. Cannabidiol (CBD) is an exogenous phytocannabinoid with therapeutic potential for individuals with anxiety, poor sleep, and ...
Bonn-Miller, Marcel +2 more
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The translational regulator dFMRP interacts with epidermal growth factor receptor to regulate apoptosis in Drosophila [PDF]
, 2016 poster abstractPosttranscriptional gene regulation is required for all aspects of cellular and tissue development and is a major mechanism underlying many diseases ranging from neurological disorders to cancer.
Sherwood, Jacqueline E. +2 more
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