Results 1 to 10 of about 727 (93)

GLP-1 Induces the Expression of FNDC5 Derivatives That Execute Lipolytic Actions [PDF]

Frontiers in Cell and Developmental Biology, 2021
Multiple GLP-1-derived therapeutics are clinically used to treat type 2 diabetes and obesity. However, the underlying mechanism of how these drugs regulate the body weight of obese patients remains incompletely understood.
Hui Li, Hui Li, William Donelan, Fang Wang, Peilan Zhang, Lijun Yang, Yousong Ding, Dongqi Tang, Shiwu Li   +8 more
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Effect of exercise training on the FNDC5/BDNF pathway in spontaneously hypertensive rats [PDF]

Physiological Reports, 2019
Increased sympathetic activity contributes to the development of cardiovascular diseases such as hypertension. Exercise training lowers sympathetic activity and is beneficial for the prevention and treatment of hypertension and associated cognitive ...
Tao Wang, Melissa T. Maltez, Heow Won Lee, Monir Ahmad, Hong‐Wei Wang, Frans H. H. Leenen   +5 more
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FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control [PDF]

Cell Death and Disease
Mitochondrial dysfunction and oxidative stress are important mechanisms for secondary injury after traumatic brain injury (TBI), which result in progressive pathophysiological exacerbation.
Yufeng Ge, Xun Wu, Yaning Cai, Qing Hu, Jin Wang, Shenghao Zhang, Baocheng Zhao, Wenxing Cui, Yang Wu, Qiang Wang, Tian Feng, Haixiao Liu, Yan Qu, Shunnan Ge   +13 more
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Identification of candidate nsSNPs of the human FNDC5 gene and their structural and functional consequences using in silico analysis

Scientific Reports
Fibronectin type-III domain containing protein-5 (FNDC5), predominantly expressed in skeletal muscles, encodes FNDC5 transmembrane-protein. A segment of this protein is cleaved and secreted into blood as irisin, which promotes browning of white adipose ...
Sadaf Majeed, Hira Moin, Maaz Waseem, Zoya Khalid, Sumra Wajid Abbasi, Kashaf Rasool   +5 more
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FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms

Redox Biology
Cardiotoxicity remains a major limiting factor in the clinical implementation of anthracycline chemotherapy. Though the etiology of doxorubicin-dependent heart damage has yet to be fully elucidated, the ability of doxorubicin to damage DNA and trigger ...
Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity   +9 more
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FNDC5 expression closely correlates with muscle fiber types in porcine longissimus dorsi muscle and regulates myosin heavy chains (MyHCs) mRNA expression in C2C12 cells [PDF]

PeerJ, 2021
Background Irisin (a glycosylated protein) is cleaved from fibronectin type III domain-containing protein 5 (FNDC5), which is expressed mainly in animal muscle tissues and has multiple metabolic regulatory activities.
Xiao-Ming Men, Zi-Wei Xu, Xin Tao, Bo Deng, Ke-Ke Qi   +4 more
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Low FNDC5/Irisin expression is associated with aggressive phenotypes in gastric cancer

Frontiers in Pharmacology, 2022
Background: FNDC5 belongs to the family of proteins called fibronectin type III domain-containing which carry out a variety of functions. The expression of FNDC5 is associated with the occurrence and development of tumors.
Luyun Xu, Luyun Xu, Yan Ye, Yuqin Sun, Wenting Zhong, Liangjie Chi, Youyu Lin, Hongxia Liu, ShengZhao Li, Hui Chen, Chengcheng Li, Yuxuan Lin, Qingshui Wang, Qingshui Wang, Fangqin Xue, Yao Lin   +15 more
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Low-intensity pulsed ultrasound triggers a beneficial neuromodulation in dementia mice with chronic cerebral hypoperfusion via activation of hippocampal Fndc5/irisin signaling

Journal of Translational Medicine, 2023
Background Exercise-related signaling Fndc5/irisin expresses in brain and acts as a crucial regulator of cognitive function, but its detailed roles in vascular dementia (VaD) are still unclear.
Degang Song, Xiaomin Chen, Na Zhou, Yi Yuan, Shuo Geng, Cong Zhang, Zhe Zhao, Xingran Wang, Xinran Bao, Xifa Lan, Xiangjian Zhang   +10 more
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FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells

Frontiers in Oncology, 2022
In this study, we aimed to reveal the resistance mechanism of hepatocellular carcinoma (HCC) cells to sorafenib by exploring the effect of FNDC5 on sorafenib-induced ferroptosis in HCC cells.
Huayuan Liu, Lei Zhao, Mengya Wang, Kexin Yang, Zhipeng Jin, Chengjian Zhao, Guangjun Shi   +6 more
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Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice

Biomolecules, 2021
Irisin is an exercise-induced myokine, suggested to exert beneficial effects on metabolism. However, the studies on the regulation of irisin secretion and the expression of its precursor FNDC5 have shown conflicting data. The discrepancies among previous
Songling Jiang, Lingjuan Piao, Eun Bi Ma, Hunjoo Ha, Joo Young Huh   +4 more
doaj   +1 more source