Results 91 to 100 of about 5,116 (221)
Irisin/FNDC5--An updated review.
European review for medical and pharmacological sciences, 2016 The irisin, recently identified novel molecule, has been shown to be secreted from fibronectin type III domain containing 5 (FNDC5) of skeletal muscle by an unknown protease. It has been proposed that this molecule plays an important role in converting the white adipose tissue to brown adipose tissue and regulating the energy expenditure.
K, Panati, Y, Suneetha, V R, Narala
openaire +1 more source
Comprehensive Physiology, Volume 15, Issue 6, December 2025.Combining exercise with a healthier diet improved weight gain, motor coordination, and antioxidant profiles in liver and muscle tissues in a high‐fat diet rat model of Metabolic Associated Fatty Liver Disease (MAFLD). These interventions restored molecular markers, highlighting coordinated tissue benefits and their potential in managing MAFLD in both ...
Manuel Jiménez‐García +5 more
wiley +1 more source
Irisin/FNDC5: A Novel Player in Musculoskeletal Health
Journal of Human Physiology, 2020 Osteoporosis is a major health problem that affects mainly aging and postmenopausal women and is characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility. Emerging shreds of evidence suggested that physical exercise has a beneficial effect on bone loss/osteoporosis.
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The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies
Obesity Reviews, Volume 26, Issue 12, December 2025.ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin +6 more
wiley +1 more source
BMAL1/PGC1α4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise
Journal of Sport and Health ScienceBackground: Resistance exercise leads to improved muscle function and metabolic homeostasis. Yet how circadian rhythm impacts exercise outcomes and its molecular transduction remains elusive.
Mingwei Guo +36 more
doaj +1 more source
تأثیر دویدن روی نوارگردان با شدت کم بر بیان ژن های PGC-1α، FNDC5 و BDNF درهیپوکامپ موش های صحرایی نر [PDF]
مطالعات کاربردی علوم زیستی در ورزش, 2019 زمینه و هدف: مطالعات پیشین نشان داده اند که عامل نوروتروفیک مشتق شده از مغز (BDNF) در القاء اثرات مفید فعالیت ورزشی بر مغز به ویژه هیپوکامپ نقش بسیار حیاتی دارد.
سید محمد علی عظیمی دخت +4 more
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Physiological Reports, Volume 13, Issue 24, December 2025.Abstract The main transcriptional coactivator of the WNT pathway, β‐catenin, is a well‐established regulator of adipogenesis and fat expansion, but our knowledge of how other members of the catenin family participate in adipogenesis remains incomplete. Previous studies have elucidated a role for the β‐catenin homolog, plakoglobin, in the regulation of ...
Frederic Abou Azar +6 more
wiley +1 more source
The Role of Extracellular Vesicles in Musculoskeletal Diseases
Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.ABSTRACT Extracellular Vesicles (EVs), nanoscale membrane‐bound cell‐released structures, are vital for intercellular communication and material transport. Their role in musculoskeletal health and diseases has recently drawn significant attention.
Peng‐jie Fu +6 more
wiley +1 more source
Molecular Nutrition &Food Research, Volume 69, Issue 21, November 2025.1. Experimental Design (left panel) • Icons: ∘ Three C57BL/6 mice groups ∘ Control group (Standard chow) ∘ Cafeteria diet (cookies, soda, sausage, condensed milk, chow) ∘ CAFD + Blueberry (CAFD + BB smoothie and pellets) • Group Labels: ∘ Control (C): Standard diet ∘ CAFD: Cafeteria diet + SD ∘ BB: CAFD + BB • Duration: 16 weeks • Arrow pointing to ...
Felipe Mateus Pellenz +18 more
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An Unbiased Cell‐Culture Selection Yields DNA Aptamers as Novel Senescent Cell‐Specific Reagents
Aging Cell, Volume 24, Issue 11, November 2025.Pearson et al. report the selection of DNA aptamers against senescent mouse cells, demonstrating broad binding specificity for multiple senescent mouse cell types and induction methods. Two of the aptamers bind a form of fibronectin with sub‐nanomolar affinity even in complex protein mixtures.
Keenan S. Pearson +8 more
wiley +1 more source