Results 11 to 20 of about 5,116 (221)

Gene Location, Expression, and Function of FNDC5 in Meishan Pigs [PDF]

Scientific Reports, 2017
Irisin is a new muscular regulatory factor that is generated by the cleavage of its precursor protein fibronectin type III domain-containing protein 5 (FNDC5).
Chunbo Cai, Gaojun Xiao, Lili Qian, Shengwang Jiang, Biao Li, Shanshan Xie, Ting Gao, Xiaorong An, Wentao Cui, Kui Li   +9 more
doaj   +4 more sources

CircRNA AFF4 induced by KDM1A promotes osteogenic differentiation through FNDC5/Irisin pathway [PDF]

Molecular Medicine, 2022
Background Circular RNA (circ) AFF4 was documented to regulate osteogenesis but the underlying mechanism remains to be elucidated. The preliminary study showed that circ_AFF4 may promote osteogenesis via FNDC5/Irisin.
Ansong Liu, Yong Chen, Da Zhong, Chenggong Wang, Mi Yu, Chao Liu, Zhijun Yang, Wenkang Chen, Ke Yin   +8 more
doaj   +4 more sources

The Role of FNDC5/Irisin in Cardiovascular Disease [PDF]

Cells
Disorders of cardiomyocyte metabolism play a crucial role in many cardiovascular diseases, such as myocardial infarction, heart failure and ischemia–reperfusion injury.
Maciej Grzeszczuk, Piotr Dzięgiel, Katarzyna Nowińska   +2 more
semanticscholar   +5 more sources

FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control

Cell Death and Disease
Mitochondrial dysfunction and oxidative stress are important mechanisms for secondary injury after traumatic brain injury (TBI), which result in progressive pathophysiological exacerbation.
Yufeng Ge, Xun Wu, Yaning Cai, Qing Hu, Jin Wang, Shenghao Zhang, Baocheng Zhao, Wenxing Cui, Yang Wu, Qiang Wang, Tian Feng, Haixiao Liu, Yan Qu, Shunnan Ge   +13 more
doaj   +2 more sources

FNDC5/Irisin: Physiology and Pathophysiology [PDF]

Molecules, 2022
A sedentary lifestyle or lack of physical activity increases the risk of different diseases, including obesity, diabetes, heart diseases, certain types of cancers, and some neurological diseases.
Rashid Waseem, Anas Shamsi, Taj Mohammad, M. Hassan, S. Kazim, A. Chaudhary, H. Rudayni, Mohammed Al-zharani, F. Ahmad, A. Islam   +9 more
semanticscholar   +4 more sources

PGC-1α promotes the survival of newborn neurons within AD hippocampus through activation of the FNDC5/BDNF/TrkB signaling pathway. [PDF]

Front Mol Neurosci
Background The learning and memory impairments observed in Alzheimer’s disease (AD) are strongly associated with impaired neurogenesis in the hippocampal region.
Wang YJ, Wang YX, Zou CZ, Zhang WJ, Pan W, Wang JQ, Wang H, Qian X, Han GJ, Liu FG, Wang J.   +10 more
europepmc   +2 more sources

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models [PDF]

Nature Medicine, 2018
Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-bound precursor protein fibronectin ...
Mychael V. Lourenco, Rudimar Luiz Frozza, Guilherme B. de Freitas, Hong Zhang, Grasielle C. Kincheski, Felipe C. Ribeiro, Rafaella A. Gonçalves, Julia R. Clarke, Danielle Beckman, Agnieszka Staniszewski, Hanna L. Berman, Lorena A. Guerra, Letícia Forny‐Germano, Shelby E. Meier, Donna M. Wilcock, Jorge Marcondes de Souza, Soniza Vieira Alves‐Leon, Vânia F. Prado, Marco A. M. Prado, Jose F. Abisambra, Fernanda Tovar‐Moll, Paulo Mattos, Ottavio Arancio, Sérgio T. Ferreira, Fernanda G. De Felice   +24 more
openalex   +2 more sources

Effects of low-intensity pulsed ultrasound on muscle mass and Fndc5 mRNA expression in aged male mice. [PDF]

Biogerontology
Sarcopenia, the progressive loss of skeletal muscle mass and function with aging, is a growing public health concern. Conventional treatments such as exercise, pharmacological agents, and nutritional support offer limited efficacy, especially in older ...
Kojima Y.
europepmc   +2 more sources

FNDC5/irisin is not only a myokine but also an adipokine. [PDF]

PLoS ONE, 2013
Exercise provides clear beneficial effects for the prevention of numerous diseases. However, many of the molecular events responsible for the curative and protective role of exercise remain elusive.
Arturo Roca-Rivada, Cecilia Castelao, Lucía L Senin, María O Landrove, Javier Baltar, Ana Belén Crujeiras, Luisa María Seoane, Felipe F Casanueva, María Pardo   +8 more
doaj   +5 more sources

Potential role of FNDC5 in exercise-induced improvement of cognitive function. [PDF]

J Zhejiang Univ Sci B
Cognitive dysfunction often occurs in Alzheimer’s disease, Parkinson’s disease, cerebrovascular disease, or other neurodegenerative diseases, and can significantly impact the life quality of patients and create serious social, psychological, and economic
Zhao R, Zhou X, Wang D, Tang H, Ni G.
europepmc   +2 more sources