Results 11 to 20 of about 6,156 (251)

The role of exercise-related FNDC5/irisin in depression [PDF]

Frontiers in Pharmacology
The complexity of depression presents a significant challenge to traditional treatment methods, such as medication and psychotherapy. Recent studies have shown that exercise can effectively reduce depressive symptoms, offering a new alternative for treating depression.
Yaqi Liu, Xiying Fu, Xing Zhao, Ranji Cui, Wei Yang   +4 more
europepmc   +6 more sources

FNDC5 affects invasion and migration of oral cancer by inhibiting PI3K/Akt/Snail signaling pathway [PDF]

Scientific Reports
This study first investigated how FNDC5 affected the development of oral cancer and revealed the role of FNDC5 in the migration and invasion of oral cancer.
Fang Zhao, Dongyang Xu, Xiumei Wang, Xiaofeng Wang   +3 more
doaj   +3 more sources

FNDC5/Irisin: Physiology and Pathophysiology [PDF]

Molecules, 2022
A sedentary lifestyle or lack of physical activity increases the risk of different diseases, including obesity, diabetes, heart diseases, certain types of cancers, and some neurological diseases. Physical exercise helps improve quality of life and reduces the risk of many diseases. Irisin, a hormone induced by exercise, is a fragmented product of FNDC5
Rashid Waseem, Anas Shamsi, Taj Mohammad, Md. Imtaiyaz Hassan, Syed Naqui Kazim, Anis Ahmad Chaudhary, Hassan Ahmed Rudayni, Mohammed Al-Zharani, Faizan Ahmad, Asimul Islam   +9 more
openaire   +4 more sources

Investigation of rs1746661 Polymorphism in FNDC5 Gene in Obese Patients [PDF]

Disease and Diagnosis
Background: Obesity is a multifactorial disorder that has considerably increased in developing countries in recent years. This disease results from an imbalance between energy intake and expenditure, influenced by various factors such as behavior, diet ...
Elham Hadi, Hashem Nayeri, Ali Mohammad Ahadi, Ziba Rezvani Sichani   +3 more
doaj   +3 more sources

The Role of FNDC5/Irisin in Cardiovascular Disease [PDF]

Cells
Disorders of cardiomyocyte metabolism play a crucial role in many cardiovascular diseases, such as myocardial infarction, heart failure and ischemia–reperfusion injury. In myocardial infarction, cardiomyocyte metabolism is regulated by mitochondrial changes and biogenesis, which allows energy homeostasis.
Maciej Grzeszczuk, Piotr Dzięgiel, Katarzyna Nowińska   +2 more
semanticscholar   +5 more sources

Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression [PDF]

eneuro, 2023
AbstractMajor depressive disorder (MDD) is a major cause of disability in adults. MDD is both a comorbidity and a risk factor for Alzheimer’s disease (AD), and regular physical exercise has been associated with reduced incidence and severity of MDD and AD. Irisin is an exercise-induced myokine derived from proteolytic processing of fibronectin type III
Ricardo A. S. Lima‐Filho, Juliana S. Fortuna, Danielle Cozachenco, Alinny Rosendo Isaac, Natalia Lyra e Silva, Alice Saldanha, Luís E. Santos, Sérgio T. Ferreira, Mychael V. Lourenco, Fernanda G. De Felice   +9 more
semanticscholar   +4 more sources

Progress and Challenges in the Biology of FNDC5 and Irisin [PDF]

Endocrine Reviews, 2021
Abstract In 2002, a transmembrane protein—now known as FNDC5—was discovered and shown to be expressed in skeletal muscle, heart, and brain. It was virtually ignored for 10 years, until a study in 2012 proposed that, in response to exercise, the ectodomain of skeletal muscle FNDC5 was cleaved, traveled to white adipose tissue, and induced
Steffen Maak, Frode Norheim, Christian A Drevon, Harold P Erickson   +3 more
openaire   +6 more sources

FNDC5/irisin is not only a myokine but also an adipokine. [PDF]

PLoS ONE, 2013
Exercise provides clear beneficial effects for the prevention of numerous diseases. However, many of the molecular events responsible for the curative and protective role of exercise remain elusive.
Arturo Roca-Rivada, Cecilia Castelao, Lucía L Senin, María O Landrove, Javier Baltar, Ana Belén Crujeiras, Luisa María Seoane, Felipe F Casanueva, María Pardo   +8 more
doaj   +6 more sources

Irisin and FNDC5 in retrospect [PDF]

Adipocyte, 2013
FNDC5 (fibronectin domain-containing [protein] 5) was initially discovered and characterized by two groups in 2002. In 2011 FNDC5 burst into prominence as the parent of irisin, a small protein containing the fibronectin type III domain. Irisin was proposed to be secreted by skeletal muscle cells in response to exercise, and to circulate to fat tissue ...
Erickson, HP
openaire   +6 more sources

FNDC5 is produced in the stomach and associated to body composition [PDF]

Scientific Reports, 2016
AbstractThe fibronectin type III domain-containing protein 5 (FNDC5) discovered in 2002 has recently gained attention due to its potential role in protecting against obesity. In rat, no data exist regarding FNDC5 production and regulation in the stomach.
Omar Al-Massadi, María Pardo, Silvia Barja-Fernandez, Susana B. Bravo, Rosaura Leis, Cintia Folgueira, Cintia Folgueira, Tomás García-Caballero, Cecilia Castelao, Felipe F. Casanueva, Luisa M. Seoane   +10 more
core   +13 more sources