Effects of Pretreatment With Coenzyme Q10 (CoQ10) and High-Intensity Interval Training (HIIT) on FNDC5, Irisin, and BDNF Levels, and Amyloid-Beta (Aβ) Plaque Formation in the Hippocampus of Aβ-Induced Alzheimer's Disease Rats. [PDF]
CNS Neurosci TherPhysical exercise has been shown to protect against cognitive decline in Alzheimer's disease (AD), likely through the upregulation of brain‐derived neurotrophic factor (BDNF).
Puoyan-Majd S +4 more
europepmc +2 more sources
Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review [version 2; referees: 2 approved] [PDF]
F1000Research, 2017 Background: Exercise may activate a brown adipose-like phenotype in white adipose tissue. The aim of this systematic review was to identify the effects of physical activity on the link between peroxisome proliferator-activated receptor gamma coactivator ...
Petros C. Dinas +6 more
doaj +2 more sources
Progress and Challenges in the Biology of FNDC5 and Irisin [PDF]
Endocrine Reviews, 2021 In 2002, a transmembrane protein—now known as FNDC5—was discovered and shown to be expressed in skeletal muscle, heart, and brain. It was virtually ignored for 10 years, until a study in 2012 proposed that, in response to exercise, the ectodomain of ...
S. Maak +3 more
semanticscholar +5 more sources
The role of exercise-related FNDC5/irisin in depression
Frontiers in PharmacologyThe complexity of depression presents a significant challenge to traditional treatment methods, such as medication and psychotherapy. Recent studies have shown that exercise can effectively reduce depressive symptoms, offering a new alternative for ...
Yaqi Liu +4 more
semanticscholar +4 more sources
Lack of Association Between FNDC5 Gene Polymorphisms, Serum Irisin Levels and Allergic Rhinitis
Acta Medica Alanya, 2023 Aim: Allergic rhinitis (AR) is an inflammatory nasal mucosa disease caused by type 1 immunoglobulin E-mediated reactions to allergen exposure. Irisin is a hormone released by skeletal muscles in response to exercise.
Hüseyin Günizi, Durkadın Demir Ekşi
doaj +3 more sources
The diagnostic value of FNDC5/Irisin in renal Cell Cancer [PDF]
International Brazilian Journal of Urology, 2018 Purposes: The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer.
Diler Us Altay +5 more
doaj +4 more sources
The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats [PDF]
Annals of Applied Sport Science, 2017 Background. The accumulation of excess triglyceride in the liver and a decrease in brown adipose tissue is related to the fatty liver disease. Regular physical activity can take part in regulating fat oxidation and inhibiting fat accumulation by creating
Amir Rashidlamir +2 more
doaj +2 more sources
Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice [PDF]
Advanced ScienceIdentifying the mechanistic targets of crosstalk between sarcopenia (SA) and mild cognitive impairment (MCI) is critical for screening high‐risk populations and exploring effective prevention and treatment strategies.
Xianyun Wang +16 more
doaj +2 more sources
The malignant signature gene of cancer-associated fibroblasts serves as a potential prognostic biomarker for colon adenocarcinoma patients [PDF]
Frontiers in ImmunologyBackgroundColon adenocarcinoma (COAD) is the most frequently occurring type of colon cancer. Cancer-associated fibroblasts (CAFs) are pivotal in facilitating tumor growth and metastasis; however, their specific role in COAD is not yet fully understood ...
Hao Zhang +5 more
doaj +2 more sources
Investigation of rs1746661 Polymorphism in FNDC5 Gene in Obese Patients [PDF]
Disease and DiagnosisBackground: Obesity is a multifactorial disorder that has considerably increased in developing countries in recent years. This disease results from an imbalance between energy intake and expenditure, influenced by various factors such as behavior, diet ...
Elham Hadi +3 more
doaj +2 more sources