Highly Bioavailable Curcumin, but Not Native Curcumin, Combined With Exercise Improves Cognitive Function in Mice. [PDF]
Food Sci NutrHighly bioavailable curcumin (HC), but not native curcumin, combined with exercise improves cognitive function in mice, even though exercise alone does not have this effect. The Sirt1/PGC‐1α/FNDC5/BDNF pathway and activation of CREB via CaMKII enhance the upregulation of BDNF with exercise and HC.
Suzuki T +5 more
europepmc +2 more sources
Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner
eLife, 2023 Irisin, released from exercised muscle, has been shown to have beneficial effects on numerous tissues but its effects on bone are unclear. We found significant sex and genotype differences in bone from wildtype (WT) mice compared to mice lacking Fndc5 (knockout [KO]), with and without calcium deficiency.
Anika Shimonty +8 more
openaire +5 more sources
Gene Location, Expression, and Function of FNDC5 in Meishan Pigs [PDF]
Scientific Reports, 2017 Irisin is a new muscular regulatory factor that is generated by the cleavage of its precursor protein fibronectin type III domain-containing protein 5 (FNDC5).
Chunbo Cai +9 more
doaj +4 more sources
Skeletal muscle AMPK is essential for the maintenance of FNDC5 expression [PDF]
Physiological Reports, 2015 Fibronectin type III domain-containing protein 5 (FNDC5) expression is controlled by the transcriptional co-activator, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC1α). FNDC5 expression has been shown to be increased in muscle in response to endurance exercise in some but not all studies, therefore a greater understanding ...
Lally, JSV +5 more
openaire +8 more sources
Transcriptional Intermediary Factor 1γ-Induced Irisin in Skeletal Muscle Attenuates Renal Fibrosis in Diabetic Nephropathy. [PDF]
J Cachexia Sarcopenia MuscleABSTRACT Background Transcriptional intermediary factor 1γ (TIF1γ) is a negative regulator of TGF‐β1 signalling and has been associated with patient survival in renal cell carcinoma. However, its role in diabetes mellitus (DM), particularly in diabetic nephropathy (DN), remains unclear. DN is the leading cause of chronic kidney disease (CKD).
Kim JH +10 more
europepmc +2 more sources
FNDC5/irisin, a molecular target for boosting reward-related learning and motivation [PDF]
Medical Hypotheses, 2016 Interventions focusing on the prevention and treatment of chronic non-communicable diseases are on rise. In the current article, we propose that dysfunction of the mesocortico-limbic reward system contributes to the emergence of the WHO-identified risk behaviors (tobacco use, unhealthy diet, physical inactivity and harmful use of alcohol), behaviors ...
Zsuga, Judit +4 more
openaire +5 more sources
The diagnostic value of FNDC5/Irisin in renal Cell Cancer [PDF]
International Brazilian Journal of Urology, 2018 Purposes: The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer.
Diler Us Altay +5 more
doaj +4 more sources
BMAL1/PGC1α4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise [PDF]
J Sport Health SciMingwei Guo +36 more
europepmc +3 more sources
The Effects of Obesity, Six Weeks of Aerobic Training, and Cold Water Exposure on the Expression of FNDC5 and UCP1 Genes in Male Wistar Rats. [PDF]
Int J Endocrinol MetabBackground Obesity is a complex disease that has become increasingly prevalent. While obesity itself is not new, its widespread occurrence is a more recent concern. Stimulating brown adipose tissue (BAT) and promoting the browning of white adipose tissue
Tohidi S +2 more
europepmc +2 more sources
Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review [version 2; referees: 2 approved] [PDF]
F1000Research, 2017 Background: Exercise may activate a brown adipose-like phenotype in white adipose tissue. The aim of this systematic review was to identify the effects of physical activity on the link between peroxisome proliferator-activated receptor gamma coactivator ...
Petros C. Dinas +6 more
doaj +4 more sources