Impact of Exercise Intensity on Cerebral BDNF Levels: Role of FNDC5/Irisin
International Journal of Molecular SciencesThe positive effects of physical exercise (EX) are well known to be mediated by cerebral BDNF (brain-derived neurotrophic factor), a neurotrophin involved in learning and memory, the expression of which could be induced by circulating irisin, a peptide derived from Fibronectin type III domain-containing protein 5 (FNDC5) produced by skeletal muscle ...
Leger, Clémence +8 more
openaire +4 more sources
SNPs in FNDC5 (irisin) are associated with obesity and modulation of glucose and lipid metabolism in Saudi subjects [PDF]
, 2016 Nasser M. Al‐Daghri +6 more
openalex +3 more sources
Evidence against a beneficial effect of irisin in humans. [PDF]
PLoS ONE, 2013 Brown adipose tissue has gained interest as a potential target to treat obesity and metabolic diseases. Irisin is a newly identified hormone secreted from skeletal muscle enhancing browning of white fat cells, which improves systemic metabolism by ...
Silja Raschke +15 more
doaj +5 more sources
New insights into the cellular activities of Fndc5/Irisin and its signaling pathways [PDF]
Cell & Bioscience, 2020 Fndc5, a well-defined myokine and also identified as an adipokine, has a critical role in modulation of metabolism and protection against obesity. These important functions are mediated by irisin, a secretory peptide produced from proteolytic processing ...
Farzaneh Rabiee +5 more
doaj +4 more sources
Bone Adaptations to a Whole Body Vibration Protocol in Murine Models of Different Ages: A Preliminary Study on Structural Changes and Biomarker Evaluation. [PDF]
J Funct Morphol KinesiolBackground/Objectives: Whole body vibration (WBV) is a valuable tool to mitigate physiological adaptations related to age and inactivity. Although significant benefits have been found at the musculoskeletal level, including increased bone mass and ...
Cariati I +6 more
europepmc +3 more sources
Effects of Aerobic Exercise and Resistance Training on Cognitive Function: Comparative Study Based on FNDC5/Irisin/BDNF Pathway [PDF]
Dementia and Geriatric Cognitive Disorders藤田医科大学博士(医療科学)doctoral ...
4079, Izawa, Sho
core +2 more sources
Swimming alleviates myocardial fibrosis of type II diabetic rats through activating miR-34a-mediated SIRT1/PGC-1α/FNDC5 signal pathway [PDF]
PLoS OneMyocardial fibrosis can trigger heart failure in diabetic cardiomyopathy (DCM), and irisin, an exercise-induced myokine, may have a beneficial effect on cardiac function.
Yanju Guo +6 more
europepmc +3 more sources
Increased FNDC5/Irisin expression in human hepatocellular carcinoma
Peptides, 2023 The fibronectin type III domain containing 5 (FNDC5)/Irisin, a novel energy-regulating hormone, is associated with lipid and carbohydrate metabolism. It is produced in low amounts by normal hepatic tissue, while in human hepatocellular carcinoma (HCC), in which aberrant de novo lipogenesis (DNL) occurs, the hepatic expression of FNDC5/Irisin is still ...
Melania Gaggini +8 more
openalex +6 more sources
FNDC5/Irisin: A New Protagonist in Acute Brain Injury [PDF]
Stem Cells and Development, 2020 Acute brain injury (ABI), including stroke and traumatic brain injury, which accounts for a heavy burden of morbidity and mortality, results in a great loss of productive life and serious health problem worldwide. To improve patients' survival and ameliorate their outcome, effective clinical treatment strategies and new therapeutic targets are urgently
Tianqi Tu, Jianhua Peng, Yong Jiang
openalex +4 more sources