Results 31 to 40 of about 5,116 (221)
Fibronectin type III domain containing 5 (FNDC5; irisin) [PDF]
Science-Business eXchange, 2012 openalex +3 more sources
Significance of Irisin (FNDC5) Expression in Colorectal Cancer [PDF]
In Vivo, 2021 The role of irisin, the extracellular part of fibronectin type III domain containing 5 (FNDC5), in colorectal cancer (CRC) is unclear. The aim of this study was to investigate immunohistochemical (IHC) expression level of irisin and correlations with clinicopathological factors in patients with CRC.We collected 222 archived CRC samples and 26 control ...
Slawomir, Wozniak +3 more
openaire +3 more sources
Irisin, the Myokine: Guardian and Mediator in Cardiovascular System. [PDF]
Endocrinol Diabetes MetabThis graphical abstract illustrates the interconnections between key cardiovascular and cerebrovascular conditions, along with potential influencing factors. Central to the diagram are several critical pathological states: Atherosclerosis, which is linked to downstream cardiovascular events such as myocardial infarction and myocardial ischemia ...
Lan T +6 more
europepmc +2 more sources
FNDC5/Irisin counteracts lipotoxic-induced apoptosis in hypoxic H9c2 cells [PDF]
Journal of Molecular Endocrinology, 2019 Irisin is a newly identified adipokine critical to modulate body metabolism, fatty acid metabolism and oxidative stress; recent evidence suggests a cardioprotective role in ischemic injury. Loss of cardiomyocytes during acute myocardial infarction is strongly associated with energetic changes and lipotoxic-induced apoptosis.
Isabel Moscoso +4 more
openalex +4 more sources
Low FNDC5/Irisin expression is associated with aggressive phenotypes in gastric cancer
Frontiers in Pharmacology, 2022 Background: FNDC5 belongs to the family of proteins called fibronectin type III domain-containing which carry out a variety of functions. The expression of FNDC5 is associated with the occurrence and development of tumors.
Luyun Xu +15 more
doaj +1 more source
Expression of Irisin/FNDC5 in Breast Cancer
International Journal of Molecular Sciences, 2022 Irisin is a myokine formed from fibronectin type III domain-containing protein 5 (FNDC5), which can be found in various cancer tissues. FNDC5 and irisin levels have been poorly studied in the tumor tissues of breast cancer (BC). The aim of this study was to determine the levels of irisin expression in BC tissues and compare them to clinicopathological ...
Kamil Cebulski +6 more
openaire +3 more sources
Irisin/FNDC5: A participant in camel metabolism
Saudi Journal of Biological Sciences, 2021 The quantification, localization, production, function, and regulation of irisin/FNDC5 in camel species have not been previously studied. The objective of this study was to detect the irisin content in Arabian camel blood and tissues and study the gene expression of FNDC5 and PGC-1α in camel skeletal muscles and white adipose tissue depots under basal ...
Kirat, Doaa +3 more
openaire +2 more sources
GLP-1 Induces the Expression of FNDC5 Derivatives That Execute Lipolytic Actions
Frontiers in Cell and Developmental Biology, 2021 Multiple GLP-1-derived therapeutics are clinically used to treat type 2 diabetes and obesity. However, the underlying mechanism of how these drugs regulate the body weight of obese patients remains incompletely understood.
Hui Li +8 more
doaj +1 more source
Frontiers in Oncology, 2022 In this study, we aimed to reveal the resistance mechanism of hepatocellular carcinoma (HCC) cells to sorafenib by exploring the effect of FNDC5 on sorafenib-induced ferroptosis in HCC cells.
Huayuan Liu +6 more
doaj +1 more source
Cell Death Discovery, 2023 Regenerative therapy based on mesenchymal stem cells (MSCs) has great promise to achieve functional recovery in cerebral infarction patients. However, the survival rate of transplanted MSCs is extremely low because of destructive autophagy caused by the ...
Huan Wei +6 more
doaj +1 more source