Cell Death Discovery, 2023 Regenerative therapy based on mesenchymal stem cells (MSCs) has great promise to achieve functional recovery in cerebral infarction patients. However, the survival rate of transplanted MSCs is extremely low because of destructive autophagy caused by the ...
Huan Wei +6 more
doaj +1 more source
Effects of the FNDC5/Irisin on Elderly Dementia and Cognitive Impairment
Frontiers in Aging Neuroscience, 2022 Population aging is an inevitable problem nowadays, and the elderly are going through a lot of geriatric symptoms, especially cognitive impairment. Irisin, an exercise-stimulating cleaved product from transmembrane fibronectin type III domain-containing protein 5 (FNDC5), has been linked with favorable effects on many metabolic diseases.
Jin Peng, Jinhui Wu
openaire +3 more sources
Stem Cell Research & Therapy, 2020 Background The beneficial functions of bone marrow mesenchymal stem cells (BM-MSCs) decline with decreased cell survival, limiting their therapeutic efficacy for myocardial infarction (MI).
Jingyu Deng +9 more
doaj +1 more source
High-intensity interval training increases thermogenesis and metabolism through changes in regulatory proteins [PDF]
Journal of Exercise & Organ Cross Talk, 2023 The present study aimed to investigate the effect of 4 weeks of high-intensity interval training on the amounts of metabolic proteins like Sarcolipine, PGC1α and FNDC5 in SOL and EDL muscles of male Wistar rats. In the present study, 14 adult male Wistar
Amir Hosein Jafari +3 more
doaj +1 more source
Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver [PDF]
Scientific Reports, 2017 AbstractIrisin is secreted by skeletal muscle during exercise and influences energy and metabolic homeostasis. This hormone is a cleaved and secreted fragment of fibronectin type III domain-containing 5 (FNDC5). Elucidation of the FNDC5 gene regulation mechanism is necessary to clarify the function of irisin as a potential therapeutic target in human ...
Yu Jeong Jeong +7 more
openaire +4 more sources
Correlation between the muscle, blood and heart level of Irisin in exercise-trained rats with Nano selenium supplementation: A rat model of COPD [PDF]
Journal of Exercise & Organ Cross Talk, 2023 The aim of this study was to considering the correlation between the muscle fibronectin type III domain-containing protein 5 (FNDC5), blood and heart level of Irisin in exercise-trained rats with Nano selenium supplementation after intraperitoneal ...
Zohreh Fathi +3 more
doaj +1 more source
Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer [PDF]
, 2019 Background. Fibronectin type III domain-containing (FNDC) proteins fulfill manifold functions in tissue development and regulation of cellular metabolism.
Adler, Andreas +12 more
core +2 more sources
Acute Effects of Aerobic Treadmill Exercise Intensity on Expression of Irisin and FNDC5 in Male Mouse [PDF]
운동과학, 2018 PURPOSE The purpose of this study was to compare the differences in the expression of FNDC5 and irisin according to the intensity of exercise and to determine the most effective exercise intensity for the expression of FNDC5 and irisin immediately after ...
Hyun Namgoong +3 more
doaj +1 more source
Irisin evokes bradycardia by activating cardiac-projecting neurons of nucleus ambiguus. [PDF]
, 2015 Irisin is a newly identified hormone induced in muscle and adipose tissues by physical activity. This protein and its encoding gene have been identified in the brain; in addition, the precursor for irisin, FNDC5, can cross the blood-brain barrier.
Brailoiu, Eugen +3 more
core +2 more sources
FNDC5 Promotes Adipogenic Differentiation of Primary Preadipocytes in Mashen Pigs
Genes, 2022 Fibronectin type III domain-containing protein 5 (FNDC5) plays an important role in fat deposition, which can be cut to form Irisin to promote fat thermogenesis, resulting in a decrease in fat content. However, the mechanism of FNDC5 related to fat deposition in pigs is still unclear.
Hei, Wei +12 more
openaire +2 more sources