Results 51 to 60 of about 5,116 (221)

Irisin attenuates astrocyte activation and rescues memory in Alzheimer model mice [PDF]

Alzheimers Dement
Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by synapse and memory failure, and severe cognitive impairment. Physical exercise stimulates neuroprotective pathways, has pro‐cognitive actions, and has been reported to alleviate memory impairment in AD.
Heimfarth L, Ribeiro F, Fortuna J, Stelzer G, Ferreira S.   +4 more
europepmc   +2 more sources

Increased FNDC5/Irisin expression in human hepatocellular carcinoma

Peptides, 2017
The fibronectin type III domain containing 5 (FNDC5)/Irisin, a novel energy-regulating hormone, is associated with lipid and carbohydrate metabolism. It is produced in low amounts by normal hepatic tissue, while in human hepatocellular carcinoma (HCC), in which aberrant de novo lipogenesis (DNL) occurs, the hepatic expression of FNDC5/Irisin is still ...
Gaggini M, Cabiati M, Del Turco S, Navarra T, De Simone P, Filipponi F, Del Ry S, Gastaldelli A, Basta G   +8 more
openaire   +4 more sources

Correlation between the muscle, blood and heart level of Irisin in exercise-trained rats with Nano selenium supplementation: A rat model of COPD [PDF]

Journal of Exercise & Organ Cross Talk, 2023
The aim of this study was to considering the correlation between the muscle fibronectin type III domain-containing protein 5 (FNDC5), blood and heart level of Irisin in exercise-trained rats with Nano selenium supplementation after intraperitoneal ...
Zohreh Fathi, Javad Raouf Sarshoori, Mohammad Reza Masjedi, Shadmehr Mirdar   +3 more
doaj   +1 more source

Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-κB signaling pathway and Nrf2/HO-1 axis

Stem Cell Research & Therapy, 2021
Background Exosomes are considered a substitute for stem cell-based therapy for myocardial infarction (MI). FNDC5, a transmembrane protein located in the cytoplasm, plays a crucial role in inflammation diseases and MI repair.
Hongjuan Ning, Haixu Chen, Jingyu Deng, Chun Xiao, Moyan Xu, Lina Shan, Chao Yang, Zheng Zhang   +7 more
doaj   +1 more source

Irisin and FNDC5 in retrospect [PDF]

Adipocyte, 2013
FNDC5 (fibronectin domain-containing [protein] 5) was initially discovered and characterized by two groups in 2002. In 2011 FNDC5 burst into prominence as the parent of irisin, a small protein containing the fibronectin type III domain. Irisin was proposed to be secreted by skeletal muscle cells in response to exercise, and to circulate to fat tissue ...
openaire   +2 more sources

Global multi‐omics analysis of brain‐targeting exerkines in progressive treadmill‐exercised rodents [PDF]

Alzheimers Dement
Abstract Background Exercise offers neuroprotective and cognitive benefits against neurodegeneration in Alzheimer's disease, hypothesized to be due to the secretion of signaling molecules known as brain‐targeting exerkines. However, the responsiveness of these exerkines across multiple organs remains poorly understood.
Taha H.
europepmc   +2 more sources

Effects of the FNDC5/Irisin on Elderly Dementia and Cognitive Impairment

Frontiers in Aging Neuroscience, 2022
Population aging is an inevitable problem nowadays, and the elderly are going through a lot of geriatric symptoms, especially cognitive impairment. Irisin, an exercise-stimulating cleaved product from transmembrane fibronectin type III domain-containing protein 5 (FNDC5), has been linked with favorable effects on many metabolic diseases.
Jin Peng, Jinhui Wu
openaire   +3 more sources

Impact of Exercise Intensity on Cerebral BDNF Levels: Role of FNDC5/Irisin

International Journal of Molecular Sciences
The positive effects of physical exercise (EX) are well known to be mediated by cerebral BDNF (brain-derived neurotrophic factor), a neurotrophin involved in learning and memory, the expression of which could be induced by circulating irisin, a peptide ...
Clémence Leger, A. Quirié, Alexandre Méloux, Estelle Fontanier, R. Chaney, Christelle Basset, Stéphanie Lemaire, P. Garnier, A. Prigent-Tessier   +8 more
semanticscholar   +1 more source

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway [PDF]

Cell Metabolism, 2013
Exercise can improve cognitive function and has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Here we show that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and ...
Wrann, Christiane D., White, James P., Salogiannnis, John, Laznik-Bogoslavski, Dina, Wu, Jun, Ma, Di, Lin, Jiandie D., Greenberg, Michael E., Spiegelman, Bruce M.   +8 more
openaire   +2 more sources

Exercise-induced myokine FNDC5/irisin functions in cardiovascular protection and intracerebral retrieval of synaptic plasticity

Cell & Bioscience, 2019
Physical exercise is well known to benefit human health at every age. However, the exact mechanism through which physical exercise improves health remains unknown.
Xin Zhou, MengMeng Xu, Joseph L. Bryant, Jianjie Ma, Xuehong Xu   +4 more
doaj   +1 more source