Raspberry ketone promotes FNDC5 protein expression via HO-1 upregulation in 3T3-L1 adipocytes
Chinese Journal of Physiology, 2022 Obesity is a global health problem and a risk factor for cardiovascular diseases and cancers. Exercise is an effective intervention to combat obesity. Fibronectin type III domain containing protein 5 (FNDC5)/irisin, a myokine, can stimulate the browning ...
Yung-Chieh Tsai +4 more
doaj +1 more source
Antioxidants, 2022 Irisin, a novel myokine, is secreted by the muscle following proteolytic cleavage of fibronectin type III domain containing 5 (FNDC5) and is considered a novel regulator of glucose homeostasis.
Rajesh Parsanathan, Sushil K. Jain
doaj +1 more source
CircRNA AFF4 induced by KDM1A promotes osteogenic differentiation through FNDC5/Irisin pathway
Molecular Medicine, 2022 Background Circular RNA (circ) AFF4 was documented to regulate osteogenesis but the underlying mechanism remains to be elucidated. The preliminary study showed that circ_AFF4 may promote osteogenesis via FNDC5/Irisin.
Ansong Liu +8 more
doaj +1 more source
The Role of Irisin in Various Organs of the Human Body with Emphasis on the Beneficial Effects on Glucose Homeostasis [PDF]
مجله دانشکده پزشکی اصفهان, 2022 Maintaining a normal blood glucose level depends on the proper and coordinated functioning of several systems in the body. Understanding the various molecular mechanisms that regulate blood glucose levels has significant implications for maintaining ...
Farzaneh Yazdanimoghaddam +2 more
doaj +1 more source
FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle [PDF]
, 2016 [Abstract] Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a controversy exists concerning irisin origin, regulation and function.
Cordido, Fernando +5 more
core +2 more sources
PLoS ONE, 2014 The transmembrane protein FNDC5 was recently characterized as precursor of an exercise induced myokine named irisin. Previous studies found a relationship between circulating irisin levels and muscle mass in humans. Consequently, we tested the hypothesis
Katrin Komolka +5 more
doaj +1 more source
The effect of eight weeks of interval and continuous endurance training on PGC-1α and FNDC5 gene expression in the gastrocnemius muscle of male Wistar rats [PDF]
Journal of Exercise & Organ Cross Talk, 2022 The purpose of this study was to investigate and compare the effect of eight weeks of continuous and interval training on PGC-1α and FNDC5 gene expression in the gastrocnemius muscle of male Wistar rats.
Shaghayegh Farjad Fard +3 more
doaj +1 more source
Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. [PDF]
, 2012 The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators
Seldin, Marcus M, Wong, G William
core +1 more source
An important issue that has to be addressed: Irisin crosstalk with cancerous tissues [PDF]
Journal of Exercise & Organ Cross Talk, 2021 Dear Editor-in-ChiefMany studies have shown that regular physical activity has a significant effect on improving a range of disorders such as metabolic syndrome, cardiovascular disease, and cancer.
Saleh Rahmati-Ahmadabad
doaj +1 more source
Association of Irisin/FNDC5 with ERRα and PGC-1α Expression in NSCLC
International Journal of Molecular Sciences, 2022 The rapid growth and division of cancer cells are associated with mitochondrial biogenesis or switching to glycolysis. ERRα, PGC-1α and irisin/FNDC5 are some of the proteins that can influence these processes. The aim of this study was to determine the correlation of these proteins in non-small cell lung cancer (NSCLC) and to investigate their ...
Katarzyna Nowińska +7 more
openaire +2 more sources