Results 81 to 90 of about 5,116 (221)

The effect of exercise interventions on Irisin level

EXCLI Journal : Experimental and Clinical Sciences, 2022
Irisin is a hormone that is offered to be a hopeful remedial target in obesity and type 2 diabetes. It has received striking attention recently, whereas, the interactions between exercise training and irisin are still unclear.
Gholam Rasul Mohammad Rahimi, Keyvan Hejazi, Martin Hofmeister   +2 more
doaj   +1 more source

Early sensorimotor restriction in rats induces age‐dependent mitochondrial alterations in skeletal muscles and brain structures

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to determine whether early sensorimotor restriction (SMR) alters mitochondrial enzyme activities in rat muscles and brain structures. SMR was induced via immobilizing the hind limbs of pups for 16 h per day during the dark phase from birth to postnatal day (PND) 28.
Mélanie Van Gaever, Olivier Dupuy, Erwan Dupont, Marie‐Hélène Canu, Frederic Daussin   +4 more
wiley   +1 more source

Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer’s disease

Molecular Brain, 2018
The deposition of Amyloid-beta peptides (Aβ) is detected at an earlier stage in Alzheimer’s disease (AD) pathology. Thus, the approach toward Aβ metabolism is considered to play a critical role in the onset and progression of AD.
Yasuha Noda, Akira Kuzuya, Kyousuke Tanigawa, Mitsugu Araki, Ryoko Kawai, Biao Ma, Yoko Sasakura, Masato Maesako, Yoshitaka Tashiro, Masakazu Miyamoto, Kengo Uemura, Yasushi Okuno, Ayae Kinoshita   +12 more
doaj   +1 more source

New insights into the cellular activities of Fndc5/Irisin and its signaling pathways

Cell & Bioscience, 2020
Fndc5, a well-defined myokine and also identified as an adipokine, has a critical role in modulation of metabolism and protection against obesity. These important functions are mediated by irisin, a secretory peptide produced from proteolytic processing ...
Farzaneh Rabiee, Liana Lachinani, Sarvenaz Ghaedi, Mohammad Hossein Nasr-Esfahani, Timothy L. Megraw, Kamran Ghaedi   +5 more
doaj   +1 more source

Cross‐Sectional and Longitudinal Associations of Irisin and Adiponectin With Obesity, Sarcopenia and Sarcopenic Obesity

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Irisin, an exercise‐induced myokine and adiponectin, an adipocyte‐derived hormone, are involved in energy metabolism and musculoskeletal health. However, their associations with obesity, abdominal obesity, sarcopenia and sarcopenic obesity remain unclear, and longitudinal evidence is limited.
Yejin Kim, Hong Ji Song, Dong‐Hyun Kim, Jin‐Young Jeong, Kyung Hee Park, Yong Soon Park, Jwa‐Kyung Kim, Hye‐Mi Noh   +7 more
wiley   +1 more source

Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats [PDF]

Metabolism, 2013
There is debate as to whether fibronectin type III domain containing 5 (FNDC5) and its protein product irisin are therapeutic targets for obesity-associated maladies. Thus, we sought to examine FNDC5 mRNA within skeletal muscle of obese/diabetic-prone Otsuka Long-Evans Tokushima Fatty (OLETF) rats versus lean/healthy Long Evans Tokushima Otsuka (LETO ...
Michael D, Roberts, David S, Bayless, Joseph M, Company, Nathan T, Jenkins, Jaume, Padilla, Thomas E, Childs, Jeffrey S, Martin, Vincent J, Dalbo, Frank W, Booth, R Scott, Rector, M Harold, Laughlin   +10 more
openaire   +2 more sources

Irisin ameliorates age‐associated sarcopenia and metabolic dysfunction

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Age‐associated sarcopenia is characterized of progressed loss of skeletal muscle power, mass, and function, which affects human physical activity and life quality.
Mingwei Guo, Jing Yao, Jin Li, Jun Zhang, Dongmei Wang, Hui Zuo, Yi Zhang, Bo Xu, Yinzhao Zhong, Fei Shen, Jian Lu, Shuzhe Ding, Cheng Hu, Lingyan Xu, Junjie Xiao, Xinran Ma   +15 more
doaj   +1 more source

Urotensin II Induces Mice Skeletal Muscle Atrophy Associated with Enhanced Autophagy and Inhibited Irisin Precursor (Fibronectin Type III Domain Containing 5) Expression in Chronic Renal Failure

Kidney & Blood Pressure Research, 2019
Background/Aims: Skeletal muscle atrophy is one of the main manifestations of protein energy wasting. We hypothesized that urotensin II (UII) can lead to skeletal muscle atrophy through upregulating autophagy and affecting Irisin precursor fibronectin ...
Ya-Jing Pan, Si-Jia Zhou, Jin Feng, Qiong Bai, La-Ta A, Ai-Hua Zhang   +5 more
doaj   +1 more source

A Traditional Review of the Slimming Myokine: Current Approaches to FNDC5/Irisin [PDF]

, 2022
Diler Us Altay
openalex   +1 more source

Irisin‐Loaded Dissolving Microneedles Promote Rapid Wound Healing

Advanced NanoBiomed Research, Volume 5, Issue 12, December 2025.
Schematic of effective wound healing facilitated by water‐degradable microneedles loaded with irisin that enhance irisin penetration, fibroblast migration, differentiation, and extracellular matrix synthesis at the wound site. Irisin, an exercise‐induced myokine with anti‐inflammatory and regenerative activity, is incorporated into dissolving poly ...
Yu‐Chi Pan, Sheng‐Hua Wu, Hung‐Pei Tsai, Ming‐Hong Tai, Chien‐Ju Lin, Hung‐Wei Yang, Shu‐Hung Huang   +6 more
wiley   +1 more source