Results 91 to 100 of about 1,259,124 (381)

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. [PDF]

, 2017
Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The
Bardel, Bernadette, Block, Helena, Bokemeyer, Arne, Boras, Mark, Heitplatz, Barbara, Kliche, Stefanie, Lowell, Clifford, Reinhold, Annegret, Rossaint, Jan, Van Marck, Veerle, Volmering, Stephanie, Zarbock, Alexander   +11 more
core   +2 more sources

In vivo epidermal migration requires focal adhesion targeting of ACF7

Nature Communications, 2016
Turnover of focal adhesions allows cell retraction, which is essential for cell migration. The mammalian spectraplakin protein, ACF7 (Actin-Crosslinking Factor 7), promotes focal adhesion dynamics by targeting of microtubule plus ends towards focal ...
J. Yue, Yao Zhang, W. Liang, Xuewen Gou, Philbert Lee, Han Liu, Wanqing Lyu, Wei-Jen Tang, Shao-yu Chen, Feng Yang, Hong Liang, Xiaoyang Wu   +11 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

ADAMTS9-regulated pericellular matrix dynamics governs focal adhesion-dependent smooth muscle differentiation [PDF]

, 2018
Focal adhesions anchor cells to extracellular matrix (ECM) and direct assembly of a pre-stressed actin cytoskeleton. They act as a cellular sensor and regulator, linking ECM to the nucleus.
Apte, S.S., Buttle, D.J., Dancevic, C.M., Drazba, J., Du, Y., Gueye, N.A., Mead, T.J., Nelson, C.M., Vankemmelbeke, M.   +8 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo [PDF]

, 2013
Neutrophil recruitment from blood to extravascular sites of sterile or infectious tissue damage is a hallmark of early innate immune responses, and the molecular events leading to cell exit from the bloodstream have been well defined1,2. Once outside the
Afonso, P., Angermann, B., Germain, R., Kastenmüller, W., Lämmermann, T., Parent, C., Wang, J.   +6 more
core   +2 more sources

Vimentin contributes to epithelial-mesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation

OncoTarget, 2015
Modulations of cytoskeletal organization and focal adhesion turnover correlate to tumorigenesis and epithelial-mesenchymal transition (EMT), the latter process accompanied by the loss of epithelial markers and the gain of mesenchymal markers (e.g ...
Ching-Yi Liu, Hsi-Hui Lin, M. Tang, Yang-Kao Wang   +3 more
semanticscholar   +1 more source

Polarized focal adhesion kinase activity within a focal adhesion during cell migration

Nature Chemical Biology, 2023
Focal adhesion kinase (FAK) relays integrin signaling from outside to inside cells and contributes to cell adhesion and motility. However, the spatiotemporal dynamics of FAK activity in single FAs is unclear due to the lack of a robust FAK reporter, which limits our understanding of these essential biological processes.
Xiaoquan Li, Joseph Dale Combs, Khalid Salaita, Xiaokun Shu   +3 more
openaire   +4 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation [PDF]

, 2014
The force-dependent interaction between talin and vinculin plays a crucial role in the initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the mechano-sensitive compact N-terminal region of the talin rod, and show that
A Banno, A Carisey, A Del Rio, A Kishino, AD Bershadsky, AR Gingras, BD Hoffman, BT Goult, BT Goult, C Ciobanasu, C Grashoff, E Goksoy, F Margadant, GCK Roberts, H Chen, H Chen, H Chen, H Fu, H Hirata, H-S Lee, H-S Lee, J Han, JD Humphries, NJ Anthis, PR Elliott, PRJ Bois, PRJ Bois, SE Lee, SJ Ellis, T Wieprecht, TJ Proszynski, V Vogel, Y Gao, Y Sawada, Y Sawada   +34 more
core   +2 more sources