Results 181 to 190 of about 113,919,521 (303)

The Kallikrein-Kinin System: Proteolytic Orchestrators of Tissue Barrier Disruption in Inflammation and Cancer. [PDF]

Int J Mol Sci
Cárdenas-Oyarzo A, Figueroa CD, Huilcamán R, Turones L, Martínez-Huenchullán S, Ehrenfeld P.   +5 more
europepmc   +1 more source

Arrayed Magnetic Accelerator Synergistically Enhances Orthodontic Tooth Movement via Microtubule Assembly‐Mediated Periodontal Remodeling

Advanced Science, EarlyView.
Mechanical orthodontic treatment for malocclusion is limited by slow remodeling and risks due to poor biomechanical sensing. This study shows that static magnetic fields (SMFs) enhance mechanical sensation in periodontal ligament cells, promoting inflammation and osteoclast activity.
Yiling Lou, Jiwei Sun, Peng Chen, Caihong Mao, Junyuan Zhang, Haoqi Lei, Xiaoqing Han, Yaxuan Zhang, Yuheng Jiang, Yulin Jia, Bin Su, Lili Chen   +11 more
wiley   +1 more source

Bioactive Chitosan Oligosaccharides Derived from Crab Shell Waste Stimulate Osteogenic Differentiation in Pre-Osteoblast Cells. [PDF]

Mar Drugs
Duangprom S, Janpan P, Songkoomkrong S, Namwongsa S, Amonruttanapun P, Saetan J, Sung Y, Prasattongosoth V, Saengkun Y, Tamtin M, Sobhon P, Kornthong N.   +11 more
europepmc   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Comparison of transcriptome sequencing between Nubian goats and Hu sheep under heat stress

Siliao yanjiu
The experiment aimed to investigate the differences and similarities in differentially expressed genes (DEGs) and pathways related to muscle growth and development between Nubian goats and Hu sheep under heat stress (HS) conditions.
ZHANG Yu, TIAN Quan, GUO Yazhou, ZHOU Yuzhen, DU Juan, REN Jiancun   +5 more
doaj  

Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review). [PDF]

Mol Med Rep
Chen C, Hu X, Wei S, Deng Y, Zhao Q, Chen G, Cheng Z, Ji J, Gu J.   +8 more
europepmc   +1 more source

FOCAL ADHESION KINASE MEDIATES MICROVASCULAR LEAKAGE AND ENDOTHELIAL BARRIER DYSFUNCTION IN INTESTINAL ISCHEMIA-REPERFUSION INJURY

FOCAL ADHESION KINASE MEDIATES MICROVASCULAR LEAKAGE AND ENDOTHELIAL BARRIER DYSFUNCTION IN INTESTINAL ISCHEMIA-REPERFUSION ...
Clement Yang (20276688), Rebecca Patrick (13084221), Mack H Wu (20276682), Briana Pando (20276685)   +3 more
core  

The Interplay of Curvature, Geometry, and Topology Shapes Tissue Organisation in Epithelial Shells

Advanced Science, EarlyView.
Purely geometric 3D Voronoi models predict the organisation of epithelial shells. The interplay of curvature, geometry, and topology enriches the number of pentagons in shells with lower number of cells. Small MDCK cysts and Mouse embryos match the top polygonal configurations in a compactness‐based ranking derived from the Voronoi model. In conclusion,
Laura Morato, Jesús A. Andrés‐San Román, Juan Garrido‐García, Carmen Gordillo‐Vázquez, Ana M. Palacios, Elisabeth Lidueña‐Fernández, Katie McDole, Pedro Gómez‐Gálvez, Valentina Annese, Luis M. Escudero   +9 more
wiley   +1 more source

XuanBi Mitigates Rheumatoid Arthritis via Regulation of ECM-Receptor Interactions and IL-17 Signaling: Insights From Integrated Proteomic and Pharmacological Analyses. [PDF]

Food Sci Nutr
Zhu H, Pan Z, Lu Y, Xia P, He W, Zeng J, Wang F, Liu X, Wei M.   +8 more
europepmc   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source