Results 301 to 310 of about 66,236 (336)
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Nature, 1992
Increasing evidence indicates that the integrin family of cell adhesion receptors can transduce biochemical signals from the extracellular matrix to the cell interior to modulate cell growth and differentiation. We have shown that integrin/ligand interactions can trigger tyrosine phosphorylation of a protein of M(r) 120,000 (pp120), so it is possible ...
J. Guan, D. Shalloway
semanticscholar +5 more sources
Increasing evidence indicates that the integrin family of cell adhesion receptors can transduce biochemical signals from the extracellular matrix to the cell interior to modulate cell growth and differentiation. We have shown that integrin/ligand interactions can trigger tyrosine phosphorylation of a protein of M(r) 120,000 (pp120), so it is possible ...
J. Guan, D. Shalloway
semanticscholar +5 more sources
Focal adhesion kinase: an integrin-linked protein tyrosine kinase.
Trends in Cell Biology, 1993Recent evidence has shown that binding of integrins to components of the extracellular matrix serves to initiate cellular signals, resulting in changes in cytoskeletal architecture and activation of intracellular signalling pathways. Here we review the evidence that protein tyrosine kinases, including focal-adhesion-associated kinases, play a central ...
M. Schaller, J. Parsons
semanticscholar +5 more sources
Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function
Immunologic Research, 2005Pyk2 is a protein tyrosine kinase expressed primarily in brain and hematopoietic cells. It becomes activated in response to stimulation through numerous receptors, including integrins, chemokine receptors, and antigen receptors, and is found in association with src-family kinases. Although this enzyme associates with many proteins known to be important
H. Ostergaard, Tara L. Lysechko
semanticscholar +3 more sources
Current Pharmaceutical Design, 2007
The formation of capillary-like structures during angiogenesis requires a series of well-orchestrated cellular events allowing endothelial cells and pericytes to migrate into the perivascular space. The proper activation of the migratory machinery in these cells is fine controlled by the presence of angiogenic challenges and by the interactions with ...
A. Angelucci, M. Bologna
semanticscholar +4 more sources
The formation of capillary-like structures during angiogenesis requires a series of well-orchestrated cellular events allowing endothelial cells and pericytes to migrate into the perivascular space. The proper activation of the migratory machinery in these cells is fine controlled by the presence of angiogenic challenges and by the interactions with ...
A. Angelucci, M. Bologna
semanticscholar +4 more sources
Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways.
Current Opinion in Cell Biology, 1997J. Parsons, S. Parsons
semanticscholar +3 more sources
A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK
Nature, 1996A. Richardson, J. Parsons
semanticscholar +3 more sources
Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma
Cancer, 1999Focal adhesion kinase (FAK) is a tyrosine kinase that is important to such key functions such as cell adhesion, motility, and invasion. A MEDLINE search of the years 1980-1998 found no previous reports of FAK expression in human ovarian carcinoma. The authors performed experiments to determine whether FAK expression is elevated in this disease.Ten ...
P L, Judson +3 more
openaire +2 more sources