Results 51 to 60 of about 3,991,041 (284)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Review of advances in Martian focal mechanisms
地球与行星物理论评Earthquakes represent dynamic processes in rocky planets where accumulated stress leads to sudden rupture, block movement, and energy release. Investigating their origin mechanisms not only advances our understanding of planetary stress accumulation and ...
Kexu Shi, Weijia Sun
doaj +1 more source
Annals of Geophysics, 2000 The Southern Apennines and the Sicilian-Calabrian regions belong to the complex geodynamic Central Mediterranean area, which is dominated by the NNW-SSE convergence of the European and African plates and is strongly affected by the presence of Neogene ...
A. Amato, A. Frepoli
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Focal mechanisms in anisotropic media [PDF]
Geophysical Journal International, 2005 SUMMARY Focal mechanisms of seismic sources in anisotropic media are more complicated than in isotropic media. Planar shear faulting produces pure double-couple (DC) mechanism in isotropy, but generally non-double-couple (non-DC) mechanism in anisotropy.
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Water inrush inoculation process in mines based on moment tensor inversion
工程科学学报, 2015 To achieve the effective monitoring of rock failure events in the mine water inrush inoculation process, a moment tensor inversion method based on digital seismology was introduced to process abnormal microseismic events monitored in Hebei Fanshan ...
CHAI Jin-fei +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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, 2018 Focal adhesions are dynamic multiprotein structures connecting cells to their surrounding microenvironment. Cells receive critical mechanical signals from adhesions that control many cellular processes including wound healing, differentiation, development, and cancer.
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source