Results 1 to 10 of about 2,970 (93)

Folate Receptor Beta Signaling in the Regulation of Macrophage Antimicrobial Immune Response: A Scoping Review [PDF]

Biomedicine Hub
Introduction: Folate, vitamin B9, is a water-soluble vitamin that is essential to cellular proliferation and division. In addition to the reduced folate carrier, eukaryotic cells take up folate through endocytosis mediated by one of two GPI-anchored ...
Anna C.C. Castelo Branco, Lisa M. Rogers, David M. Aronoff   +2 more
doaj   +3 more sources

Glycosyl Mobile Radical Structures of Folic Acid Receptors Impact the Internalization of Functionalized Folate Amphiphilic Alternating Copolymer in Cancer Cells

Receptors
Folate receptor alpha (FRα) is a glycosylphosphatidylinositol (GPI) membrane-anchored protein containing three N-glycosylated residues at the N47, N139, and N179 termini.
Emilyn B. Aucoin, Elizabeth Skapinker, Abdulrahman M. Yaish, Yunfan Li, Haley L. Kombargi, Daniel Jeyaraj, Pankaj Garg, Nicole Mendonza, Cecile Malardier-Jugroot, Myron R. Szewczuk   +9 more
doaj   +2 more sources

Identification of a novel amphioxus leucine-rich repeat receptor involved in phagocytosis reveals a role for Slit2-N-type LRR in bacterial elimination. [PDF]

J Biol Chem, 2023
The basal chordate amphioxus is a model for tracing the origin and evolution of vertebrate immunity. To explore the evolution of immunoreceptor signaling pathways, we searched the associated receptors of the amphioxus Branchiostoma belcheri (Bb) homolog ...
Zhan Y, Zhao CS, Qu X, Xiao Z, Deng C, Li Y.   +5 more
europepmc   +2 more sources

Therapeutic and Diagnostic Potential of Folic Acid Receptors and Glycosylphosphatidylinositol (GPI) Transamidase in Prostate Cancer. [PDF]

Cancers (Basel)
Simple Summary Folate receptors can serve to increase folate uptake in cancer cells through significant overexpression, which is ultimately critical for cell proliferation and tumor growth. Therefore, the characterization of folate receptor expression in
Hoffmann M, Ermler TF, Hoffmann F, Alexa R, Kranz J, Steinke N, Leypold S, Gaisa NT, Saar M.   +8 more
europepmc   +2 more sources

Characteristics of a folate receptor-α GPI-anchored into a multilipid bilayer obtained from atomistic molecular dynamics simulations.

Journal of Chemical Theory and Computation, 2020
Thorough computational description of the properties of membrane-anchored protein receptors, which are important for example in the context of active targeting drug delivery, may be achieved by models representing as close as possible the immediate ...
G. Gocheva, Nikoleta Ivanova, Stoyan Iliev, J. Petrova, G. Madjarova, A. Ivanova   +5 more
semanticscholar   +1 more source

Neuronal Wiring Receptors Dprs and DIPs Are GPI Anchored and This Modification Contributes to Their Cell Surface Organization

eNeuro, 2023
The Drosophila Dpr and DIP proteins belong to the immunoglobulin superfamily of cell surface proteins (CSPs). Their hetero- and homophilic interactions have been implicated in a variety of neuronal functions, including synaptic connectivity, cell ...
Meike Lobb-Rabe, Wioletta I. Nawrocka, Ruiling Zhang, James Ashley, Robert A. Carrillo, E. Özkan   +5 more
semanticscholar   +1 more source

Orientational Preferences of GPI-Anchored Ly6/uPAR Proteins

International Journal of Molecular Sciences, 2022
Ly6/uPAR proteins regulate many essential functions in the nervous and immune systems and epithelium. Most of these proteins contain single β-structural LU domains with three protruding loops and are glycosylphosphatidylinositol (GPI)-anchored to a ...
M. Zaigraev, E. Lyukmanova, A. Paramonov, Z. Shenkarev, A. Chugunov   +4 more
semanticscholar   +1 more source

GPI-anchored ligand-BioID2-tagging system identifies Galectin-1 mediating Zika virus entry

iScience, 2022
Summary Identification of host factors facilitating pathogen entry is critical for preventing infectious diseases. Here, we report a tagging system consisting of a viral receptor-binding protein (RBP) linked to BioID2, which is expressed on the cell ...
Shanshan Gao, Run Shi, Jing Sun, Yanhong Tang, Zhenhua Zheng, Jing-feng Li, Huan Li, Jie Zhang, Q. Leng, Jiang Xu, Xinwen Chen, Jincun Zhao, Manjunath Sy, Liqiang Feng, Chaoyang Li   +14 more
semanticscholar   +1 more source

Human SND2 mediates ER targeting of GPI‐anchored proteins with low hydrophobic GPI attachment signals

FEBS Letters, 2021
Over 100 glycosylphosphatidylinositol‐anchored proteins (GPI‐APs) are encoded in the mammalian genome. It is not well understood how these proteins are targeted and translocated to the endoplasmic reticulum (ER).
Jing Yang, T. Hirata, Yi-Shi Liu, Xin-Yu Guo, Xiao-Dong Gao, Taroh Kinoshita, Morihisa Fujita   +6 more
semanticscholar   +1 more source

Dynamics and Molecular Interactions of GPI-Anchored CD59

Toxins, 2023
CD59 is a GPI-anchored cell surface receptor that serves as a gatekeeper to controlling pore formation. It is the only membrane-bound inhibitor of the complement membrane attack complex (MAC), an immune pore that can damage human cells. While CD59 blocks
Tomas B Voisin, E. C. Couves, Edward W. Tate, D. Bubeck   +3 more
semanticscholar   +1 more source