Results 11 to 20 of about 3,009 (130)
The Role of the CLIC/GEEC Endocytic Pathway for Mechanophysical Transfection of DNA. [PDF]
J Gene MedThe clathrin‐independent carriers/GPI‐enriched endocytic compartments (CLIC/GEEC or CG) pathway is a high‐capacity, clathrin‐, and dynamin‐independent route for nutrient and membrane‐anchored cargo uptake of DNA. This overview highlights its molecular mechanisms, regulation, cellular roles, and relevance to mechanophysical DNA transfection.
Weaver S +8 more
europepmc +2 more sources
Fundamental Neurochemistry Review: Sphingolipids and Ceramides in Brain Development. [PDF]
J NeurochemCeramides and sphingolipids in brain development and cell compartments. Ceramides and sphingolipids are known to influence multiple steps of brain development, including the formation of the neural tube, neural stem cell polarity and proliferation at the ventricular boundary, neuronal migration—for example, whilst migrating on radial glial processes ...
Chinnappa K, Ballorin F, Francis F.
europepmc +2 more sources
Molecular Therapy: Oncolytics, 2023 Transforming growth factor β (TGF-β) is a pleiotropic cytokine expressed by a wide range of cell types and is known for hampering the effectiveness of cancer immune cell therapeutic approaches.
Svend Petersen +6 more
semanticscholar +1 more source
Plant Physiology, 2020 Proteins of the p24 family interact with glycosylphosphatidylinositol (GPI)-anchored proteins for their efficient ER export and transport to the plasma membrane in Arabidopsis.
César Bernat-Silvestre +6 more
semanticscholar +2 more sources
Journal of Biological Chemistry, 2018 Bacillus thuringiensis Cry toxins are used worldwide for controlling insects. Cry1Ab is produced as a 130-kDa protoxin that is activated by proteolytic removal of an inert 500 amino-acid-long C-terminal region, enabling the activated toxin to bind to ...
Arlen Peña-Cardeña +6 more
semanticscholar +1 more source
Quality-controlled ceramide-based GPI-anchored protein sorting into selective ER exit sites.
Cell Reports, 2022 Glycosylphosphatidylinositol-anchored proteins (GPI-APs) exit the endoplasmic reticulum (ER) through a specialized export pathway in the yeast Saccharomyces cerevisiae.
Sofía Rodriguez-Gallardo +13 more
semanticscholar +1 more source
Cell Biochemistry and Biophysics, 2017 The central mechanism for the transmission of the prion protein misfolding is the structural conversion of the normal cellular prion protein to the pathogenic misfolded prion protein, by the interaction with misfolded prion protein. This process might be
Yuri L. Nemoto +7 more
semanticscholar +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Food Frontiers, Volume 7, Issue 2, March 2026.A graphical representation of how Lactobacillus plantarum NCU001563 alleviates ulcerative colitis. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) driven by microbial dysbiosis, barrier dysfunction, and immune dysregulation.
Philippe Madjirebaye +12 more
wiley +1 more source
Applications of Lysosome‐Targeting Receptors (LTRs) in Targeted Protein Degradation
MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.Targeted protein degradation based on LYTAC technology has recently emerged as a research hotspot in various diseases. The membrane receptors recently utilized in LYTAC design are summarized in this article, with insights into current strategies, challenges, and prospects for LYTAC‐based technologies.
Lijian Shen +4 more
wiley +1 more source