Results 21 to 30 of about 3,009 (130)

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors

eLife, 2019
We have used misfolded prion protein (PrP*) as a model to investigate how mammalian cells recognize and degrade misfolded GPI-anchored proteins. While most misfolded membrane proteins are degraded by proteasomes, misfolded GPI-anchored proteins are ...
Eszter Zavodszky, R. Hegde
semanticscholar   +1 more source

Structure, Dynamics, and Interactions of GPI-Anchored Human Glypican-1 with Heparan Sulfates in a Membrane.

Glycobiology, 2020
Glypican-1 and its heparan sulfate (HS) chains play important roles in modulating many biological processes including growth factor signaling. Glypican-1 is bound to a membrane surface via a glycosylphosphatidylinositol (GPI)-anchor.
Chuqiao Dong, Y. Choi, Jumin Lee, X. F. Zhang, Aurelia R. Honerkamp-Smith, G. Widmalm, L. Lowe-Krentz, W. Im   +7 more
semanticscholar   +1 more source

Analysis of GPI-Anchored Receptor Distribution and Dynamics in Live Cells by Tag-Mediated Enzymatic Labeling and FRET

Methods and Protocols, 2020
The analysis of glycosylphosphatidylinositol (GPI)-anchored receptor distribution and dynamics in live cells is challenging, because their clusters exhibit subdiffraction-limited sizes and are highly dynamic. However, the cellular response depends on the
M. Balatskaya, A. Baglay, Y. Rubtsov, G. Sharonov   +3 more
semanticscholar   +1 more source

Anticancer Molecular Mechanisms of Epigallocatechin Gallate: An Updated Review on Clinical Trials

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Epigallocatechin gallate (EGCG), a bioactive compound abundantly exists in green tea and grapes with strong antioxidant activity and anticancer potential is a suitable approach to reduce the cancer burden. The invitro and invivo anticancer studies of EGCG proved anticancer and anti‐tumor effect through modulation of cancer signaling pathways, reduction
Ahmad Mujtaba Noman, Muhammad Tauseef Sultan, Aimen Mazhar, Iqra Baig, Jawaria Javaid, Muzzamal Hussain, Muhammad Imran, Suliman A. Alsagaby, Waleed Al Abdulmonem, Ahmed Mujtaba, Tadesse Fenta Yehuala, Mohammed M. Ghoneim, Ehab M. Mostafa, Mohamed A. Abdelgawad   +13 more
wiley   +1 more source

Co‐Binding of Methotrexate and Cyclophosphamide via Folic Acid‐Decorated Graphene Oxide Nanomaterials for Therapeutic Approach against Breast Cancer

ChemistrySelect, Volume 10, Issue 25, July 4, 2025.
Schematic Presentation of Dual Drug‐Loaded FA‐Functionalized GO Nanosystem for Targeted Breast Cancer Therapy. Abstract In this study, we developed a graphene oxide (GO)‐based nanocarrier system co‐loaded with methotrexate (MTX) and cyclophosphamide (CP) and functionalized with folic acid (FA) for targeted drug delivery.
Reyhan Yanıkoglu, Canan Yagmur Karakas, Mert Akın Insel, Merve Sevgi, Esmahan Caglar, Hasan Berkay Abdioğlu, Yagmur Isık, Hilal Calık, Ali Can Zaman, Fatih Ciftci, Rabia Cakır, Huseyin Uvet, Cem Bulent Ustundag   +12 more
wiley   +1 more source

The role of GPI-anchored membrane-bound alkaline phosphatase in the mode of action of Bt Cry1A toxins in the diamondback moth

Fundamental Research
The insecticidal Cry proteins produced by the bacterium Bacillus thuringiensis (Bt) are extensively used for pest control in formulated sprays and in genetically modified crops, but resistance to Bt toxins threatens their sustainable use in agriculture ...
Dan Sun, Qiuchen Xu, Le-Qun Guo, Yang Bai, Xuping Shentu, Xiaoping Yu, Neil Crickmore, Xuguo Zhou, A. Bravo, M. Soberón, Y. Zhang, Zhaojiang Guo   +11 more
semanticscholar   +1 more source

Soil Moisture and Its Interaction With Temperature Determine Root Metabolomes of a Himalayan Alpine Shrub

Physiologia Plantarum, Volume 177, Issue 4, July/August 2025.
ABSTRACT Climate change profoundly impacts plants. However, our understanding of plant responses to climate largely relies on plant morphology and physiology, while plant metabolomic responses, especially those within plant roots, have received much less attention.
Sayantika Banerjee, Nikita Rathore, Jaroslav Semerád, Tomáš Cajthaml, Zuzana Münzbergová, Dinesh Thakur   +5 more
wiley   +1 more source

Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling

Journal of Lipid Research, 2016
Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell surface proteins. GPIs in various organisms have a common backbone consisting of ethanolamine phosphate (EtNP), three mannoses (Mans), one non-N-acetylated glucosamine ...
T. Kinoshita, Morihisa Fujita
semanticscholar   +1 more source

Colorectal Cancer: Pathogenesis and Targeted Therapy

MedComm, Volume 6, Issue 3, March 2025.
Chromosomal instability, microsatellite instability, and the CpG island methylator phenotype are key pathogenic pathways in the adenoma–carcinoma sequence of CRC. Epigenetic remodeling and metabolic reprogramming are two major hallmarks of tumor cells, demonstrating bidirectional regulatory mechanisms across various cancers, including CRC.
Jingyuan Li, Jiashu Pan, Lisheng Wang, Guang Ji, Yanqi Dang   +4 more
wiley   +1 more source