Results 241 to 250 of about 712,331 (305)

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Dimeric architecture and membrane thinning govern substrate recognition by human signal peptide peptidase

Lea S, Bryant O, Sergejevs N, Giacomo F, Robson-Tull J, Deme J, Forrest L, Carvalho P.   +7 more
europepmc   +1 more source

Unveiling hidden intermediate states in protein folding with AI-based conditional transition clustering. [PDF]

Proc Natl Acad Sci U S A
Liu X, Cai W, Fu H, Shao X.
europepmc   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

The "slowest" way to fold a sheet of paper

A presentation explaining the proof https://doi.org/10.5281/zenodo.22019186 of determining the maximum "diameter" of a Miura-ori folded sheet at any "n ...
openaire   +1 more source

Kresling Origami‐Based Metamaterial Robot for Dynamic Electromagnetic Control

Advanced Science, EarlyView.
A reconfigurable metamaterial system integrates deformable origami units with high‐permittivity ceramic plates. Pneumatic switching between structural states alters local resonance conditions, enabling dynamic radar stealth and adaptive microwave reflection for mobile communication.
Xinxi Zeng, Long Zhou, Shaojie Xi, Yixuan Gao, Desheng Pan, Chaoyang Sun, Haoxin Sun, Xian Wang, Lingyun Qian, Peipei Li, Pengfei Zhu, Bo Li, Jiang Luo, Ji Zhou   +13 more
wiley   +1 more source

Peptides adopt stable omega-loop structures in concentrated sulfuric acid. [PDF]

Proc Natl Acad Sci U S A
Zhang JY, Dregni AJ, Petkowski JJ, Seager S, Hong M.   +4 more
europepmc   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Prion propagation is controlled by discrete structural regions of PrP rather than overall stability. [PDF]

J Biol Chem
Bhamra SK, Arora P, Liew M, Hosszu LLP, Batchelor M, Clarke AR, Bieschke J, Collinge J, Jat PS.   +8 more
europepmc   +1 more source

Multiscale Modelling of the Electrocatalysis of Microenzymes: Insights Into the Performance of Microperoxidase at an Aqueous/Graphene Interface and Their Exploitation to Improve Performance

Advanced Science, EarlyView.
A novel multiscale MD/DFT framework to elucidate microenzyme adsorption and electron transfer is reported. This method reveals distinct configurations for microperoxidase‐11 on graphene and those best suited for electron transfer. Rate constants align with the limited experimental data, establishing this framework as a tool for optimizing microenzyme ...
Milan Mijajlovic, Cheng Hu, Yuhui Sun, Matthew J. Penna, Meisam V. Kiamahalleh, Wenrong Yang, Mark J. Biggs   +6 more
wiley   +1 more source