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Physical Review D, 2004 We study classical dynamics of a probe Dp-brane moving in a background sourced by a stack of Dp-branes. In this context the physics is similar to that of the effective action for open-string tachyon condensation, but with a power-law runaway potential ...
Kofman, Lev +2 more
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BMC Biology, 2021 Background The microtubule-associated protein tau forms aggregates in different neurodegenerative diseases called tauopathies. Prior work has shown that a single P301L mutation in tau gene, MAPT, can promote alternative tau folding pathways that ...
Sang-Gyun Kang +8 more
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Innate Immune Status of Glia Modulates Prion Propagation in Early Stage of Infection
Cells, 2023 Prion diseases are progressive neurodegenerative disorders affecting humans and various mammals. The prominent neuropathological change in prion-affected brains is neuroinflammation, histopathologically characterized by reactive gliosis surrounding prion
Sang-Gyun Kang +3 more
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Comprehensive Folding Variations for Protein Folding [PDF]
Proteins: Structure, Function, and Bioinformatics, 2022 The revelation of protein folding is a challenging subject in both discovery and description. Except acquirement of accurate 3D structure for protein stable state, another big hurdle is how to discover structural flexibility for protein innate character.
Jiaan Yang +10 more
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Reorganization of Cell Compartmentalization Induced by Stress
Biomolecules, 2022 The discovery of intrinsically disordered proteins (IDPs) that do not have an ordered structure and nevertheless perform essential functions has opened a new era in the understanding of cellular compartmentalization.
Anna S. Fefilova +5 more
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Fold recognition without folds [PDF]
Protein Science, 2002 AbstractFold recognition predicts protein three‐dimensional structure by establishing relationships between a protein sequence and known protein structures. Most methods explicitly use information derived from the secondary and tertiary structure of the templates.
Koretke, K. +2 more
openaire +3 more sources
Journal of Nanobiotechnology, 2022 Conversion of β-amyloid (Aβ) peptides from soluble random-coil to aggregated protein enriched with β-sheet-rich intermediates has been suggested to play a role in the degeneration of neurons and development of Alzheimer’s disease (AD) pathology ...
Pallabi Sil Paul +7 more
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Scientific Reports, 2023 In the chapters dealing with enzyme reactions, the authors of all Biochemistry textbooks and of even more specialized texts consider that the characteristic parameters (k cat and K m ) must be determined under initial or steady-state rate conditions ...
Jean-Marie Frère +2 more
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Biomolecules, 2020 The accumulation of tau protein in the form of filamentous aggregates is a hallmark of many neurodegenerative diseases such as Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE).
Hadeel Alyenbaawi +2 more
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Susceptibility of Beavers to Chronic Wasting Disease
Biology, 2022 Chronic wasting disease (CWD) is a contagious, fatal, neurodegenerative prion disease of cervids. The expanding geographical range and rising prevalence of CWD are increasing the risk of pathogen transfer and spillover of CWD to non-cervid sympatric ...
Allen Herbst +8 more
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