Results 111 to 120 of about 217,044 (288)

Calculation of the Hinge Moments of a Folding Wing Aircraft during the Flight-Folding Process

International Journal of Aerospace Engineering, 2019
A folding wing morphing aircraft should complete the folding and unfolding process of its wings while in flight. Calculating the hinge moments during the morphing process is a critical aspect of a folding wing design.
Hao Xu, Jinglong Han, Haiwei Yun, Xiaomao Chen   +3 more
doaj   +1 more source

The optical potential of $^{6}$He in the eikonal approximation

, 2003
The new data of the elastic scattering of $^{6}$He+$^{12}$C at about 40 MeV/nucleon are analyzed in the eikonal approximation. The $^{6}$He+$^{12}$C phase-shift function is evaluated completely without any {\it ad hoc} assumption by a Monte Carlo ...
Abu-Ibrahim, Abu-Ibrahim, Abu-Ibrahim, Al-Khalili, Al-Khalili, Al-Khalili, Al-Khalili, Arai, B. Abu-Ibrahim, Becchetti, Bertsch, Blumberg, Bonaccorso, Brooke, Carlson, Cooper, Czyz, Esbensen, Fannon, Franco, Glauber, Lapoux, Lenzi, Pieper, Pudliner, Rapaport, Rusek, Sakuragi, Satchler, Suzuki, Suzuki, Tatischeff, Thompson, Varga, Wiringa, Y. Suzuki, Yabana   +36 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Predicting protein folding pathways at the mesoscopic level based on native interactions between secondary structure elements

BMC Bioinformatics, 2008
Background Since experimental determination of protein folding pathways remains difficult, computational techniques are often used to simulate protein folding.
Sze Sing-Hoi, Yang Qingwu
doaj   +1 more source

Nuclear incompressibility using the density dependent M3Y effective interaction

, 2003
A density dependent M3Y effective nucleon-nucleon (NN) interaction which was based on the G-matrix elements of the Reid-Elliott NN potential has been used to determine the incompressibity of infinite nuclear matter.
Basu D N, D N Basu, Glendenning N K, Khoa Dao T, Shlomo S   +4 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Improved design of stable and fast-folding model proteins

Folding and Design, 1996
A number of approaches to design stable and fast-folding sequences for model polypeptide chains have been based on the premise that optimization of the relative energy of the native conformation (or Z-score) is sufficient to yield stable and fast-folding sequences. Although this approach has been successful, for longer chains it often yielded sequences
Abkevich, Victor I, Gutin, Alexander M, Shakhnovich, Eugene I   +2 more
openaire   +2 more sources

Binding of charmonium with two- and three-body nuclei

, 2006
The energies of the (eta_c d) and (eta_c 3He) bound states are calculated on the basis of exact three- and four-body AGS equations. For the eta_c N interaction a Yukawa-type potential has been adopted. The calculations are done for a certain range of its
A. Fix, Alt, Alt, Belyaev, Brodsky, Brodsky, Cabrera, de Téramond, Donnachie, Fix, Fix, Fix, Garcilazo, Grassberger, Green, Harms, Kaiser, Lovelace, Luke, Mosel, N.V. Shevchenko, Oller, Pfeiffer, Rapp, Sandhas, Shevchenko, Sofianos, Tsushima, V.B. Belyaev, W. Sandhas, Wasson, Zankel   +31 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

AlphaFold distillation for inverse protein design

Scientific Reports
Inverse protein folding, the process of designing sequences that fold into a specific 3D structure, is crucial in bio-engineering and drug discovery. Traditional methods rely on experimentally resolved structures, but these cover only a small fraction of
Igor Melnyk, Aurélie Lozano, Payel Das, Vijil Chenthamarakshan   +3 more
doaj   +1 more source