Results 11 to 20 of about 792,223 (273)
Structure and stability of recombinant bovine odorant-binding protein: II. Unfolding of the monomeric forms [PDF]
PeerJ, 2016 In a family of monomeric odorant-binding proteins (OBPs), bovine OBP (bOBP), that lacks conserved disulfide bond found in other OBPs, occupies unique niche because of its ability to form domain-swapped dimers.
Olga V. Stepanenko +5 more
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Inferring the Rate-Length Law of Protein Folding [PDF]
, 2013 We investigate the rate-length scaling law of protein folding, a key undetermined scaling law in the analytical theory of protein folding. We demonstrate that chain length is a dominant factor determining folding times, and that the unambiguous ...
Lane, Thomas J., Pande, Vijay S.
core +8 more sources
The Standard Scrapie Cell Assay: Development, Utility and Prospects
Viruses, 2015 Prion diseases are a family of fatal neurodegenerative diseases that involve the misfolding of a host protein, PrPC. Measuring prion infectivity is necessary for determining efficacy of a treatment or infectivity of a prion purification procedure; animal
Jacques van der Merwe +3 more
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Biomolecules, 2023 The formation and function of membrane-less organelles (MLOs) is one of the main driving forces in the molecular life of the cell. These processes are based on the separation of biopolymers into phases regulated by multiple specific and nonspecific inter-
Sergey A. Silonov +7 more
doaj +1 more source
Journal of General Internal Medicine, 2002 On some days, a pair of local goats would walk through the halls of Tintswalo Hospital, and no one would bat an eyelash. In a 200-bed hospital run by 12 doctors in their early twenties, in a hospital where an average of 20 patients died each week from symptoms secondary to “immune compromise” (the doctors don't like to use the word AIDS in their death ...
openaire +2 more sources
Protein folds and protein folding [PDF]
Protein Engineering Design and Selection, 2010 The classification of protein folds is necessarily based on the structural elements that distinguish domains. Classification of protein domains consists of two problems: the partition of structures into domains and the classification of domains into sets of similar structures (or folds).
R Dustin, Schaeffer, Valerie, Daggett
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Molecular Neurodegeneration, 2017 Background MAPT mutations cause neurodegenerative diseases such as frontotemporal dementia but, strikingly, patients with the same mutation may have different clinical phenotypes.
Ghazaleh Eskandari-Sedighi +11 more
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Structure and stability of recombinant bovine odorant-binding protein: I. Design and analysis of monomeric mutants [PDF]
PeerJ, 2016 Bovine odorant-binding protein (bOBP) differs from other lipocalins by lacking the conserved disulfide bond and for being able to form the domain-swapped dimers.
Olga V. Stepanenko +5 more
doaj +2 more sources
Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation [PDF]
, 2017 The relationship between protein synthesis, folding and disulfide formation within the endoplasmic reticulum (ER) is poorly understood. Previous studies have suggested pre-existing disulfide links are absolutely required to allow protein folding and ...
Bulleid, Neil J. +3 more
core +1 more source
Structure and stability of recombinant bovine odorant-binding protein: III. Peculiarities of the wild type bOBP unfolding in crowded milieu [PDF]
PeerJ, 2016 Contrary to the majority of the members of the lipocalin family, which are stable monomers with the specific OBP fold (a β-barrel consisting of a 8-stranded anti-parallel β-sheet followed by a short α-helical segment, a ninth β-strand, and a disordered C-
Olga V. Stepanenko +5 more
doaj +2 more sources