Results 21 to 30 of about 792,223 (273)
Folding of Proteins with Diverse Folds [PDF]
Biophysical Journal, 2006 Using parallel tempering simulations with high statistics, we investigate the folding and thermodynamic properties of three small proteins with distinct native folds: the all-helical 1RIJ, the all-sheet beta3s, and BBA5, which has a mixed helix-sheet fold.
Mohanty, S., Hansmann, U. H. E.
openaire +3 more sources
Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation
EMBO Molecular Medicine, 2015 The cellular prion protein (PrPC) comprises a natively unstructured N‐terminal domain, including a metal‐binding octarepeat region (OR) and a linker, followed by a C‐terminal domain that misfolds to form PrPSc in Creutzfeldt‐Jakob disease.
Agnes Lau +19 more
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Amyloid fibrils degradation: the pathway to recovery or aggravation of the disease?
Frontiers in Molecular Biosciences, 2023 Background: The most obvious manifestation of amyloidoses is the accumulation of amyloid fibrils as plaques in tissues and organs, which always leads to a noticeable deterioration in the patients’ condition and is the main marker of the disease. For this
Maksim I. Sulatsky +6 more
doaj +1 more source
The unfolding of iRFP713 in a crowded milieu [PDF]
PeerJ, 2019 The exploring of biological processes in vitro under conditions of macromolecular crowding is a way to achieve an understanding of how these processes occur in vivo.
Olesya V. Stepanenko +3 more
doaj +2 more sources
Scientific Reports, 2021 In light of legislative changes and the widespread use of cannabis as a recreational and medicinal drug, delayed effects of cannabis upon brief exposure during embryonic development are of high interest as early pregnancies often go undetected.
Richard Kanyo +6 more
doaj +1 more source
Spectral characteristics of the mutant form GGBP/H152C of D-glucose/D-galactose-binding protein labeled with fluorescent dye BADAN: influence of external factors [PDF]
PeerJ, 2014 The mutant form GGBP/H152C of the D-glucose/D-galactose-binding protein with the solvatochromic dye BADAN linked to cysteine residue Cys 152 can be used as a potential base for a sensitive element of glucose biosensor system.
Alexander V. Fonin +8 more
doaj +2 more sources
Protein folding rates correlate with heterogeneity of folding mechanism [PDF]
, 2004 By observing trends in the folding kinetics of experimental 2-state proteins at their transition midpoints, and by observing trends in the barrier heights of numerous simulations of coarse grained, C-alpha model, Go proteins, we show that folding rates ...
A. R. Fersht +10 more
core +2 more sources
Bioactive Materials, 2021 Evidence suggests that increased level/aggregation of beta-amyloid (Aβ) peptides initiate neurodegeneration and subsequent development of Alzheimer's disease (AD). At present, there is no effective treatment for AD. In this study, we reported the effects
Bibin G. Anand +6 more
doaj +1 more source
Frontiers in Neuroscience, 2015 Organotypic cerebellar slices represent a suitable model for characterizing and manipulating prion replication in complex cell environments. Organotypic slices recapitulate prion pathology and are amenable to drug testing in the absence of a blood-brain ...
Hanna eWolf +7 more
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Bacteriorhodopsin folds through a poorly organized transition state. [PDF]
, 2014 The folding mechanisms of helical membrane proteins remain largely uncharted. Here we characterize the kinetics of bacteriorhodopsin folding and employ φ-value analysis to explore the folding transition state.
Bowie, James U +3 more
core +2 more sources