Results 11 to 20 of about 5,838 (218)

Histopathological effects of Methotrexate in mice livers [PDF]

Kirkuk Journal of Science, 2014
Background:Methotrexate is a folic acid antagonists that inhibits dihydrofolate reductase, resulting in a block in the synthesis of thymidine and inhibition of DNA synthesis. Methotrexate has been used for the treatment of malignancy, rheumatic disorders,
Asal A. Tawfeeq Sundus M. Taifoor
doaj   +1 more source

Caracterización bioquímica de la enzima bifuncional dihidrofolato reductasa-timidilato sintasa de Leishmania (Viannia) y su evaluación como blanco molecular

Biomédica: revista del Instituto Nacional de Salud, 2013
Introducción. La dihidrofolato reductasa (DHFR) se ha utilizado como blanco molecular en tratamientos antibacterianos, anticancerígenos y antipalúdicos.
Edison Osorio, Carolina Aguilera, Nelson Naranjo, Marcel Marin, Carlos Muskus   +4 more
doaj   +1 more source

Short story of antirheumatic therapy.VIII. The immunodepressants

Reumatismo, 2012
The use of immunosuppressive drugs in rheumatology is fairly recent, starting just after the Second World War with the introduction of the first alkylating agents in oncohematology.
P. Marson, G. Pasero
doaj   +1 more source

UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner

JCI Insight, 2022
It is currently thought that UVB radiation drives photoaging of the skin primarily by generating ROS. In this model, ROS purportedly activates activator protein-1 to upregulate MMPs 1, 3, and 9, which then degrade collagen and other extracellular matrix ...
Daniel J. Kim, Akiko Iwasaki, Anna L. Chien, Sewon Kang   +3 more
doaj   +1 more source

Evaluation of dihydrofolate reductase and dihydropteroate synthetase genotypes that confer resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum in Haiti

Malaria Journal, 2012
Background Malaria caused by Plasmodium falciparum infects roughly 30,000 individuals in Haiti each year. Haiti has used chloroquine (CQ) as a first-line treatment for malaria for many years and as a result there are concerns that malaria parasites may ...
Carter Tamar E, Warner Megan, Mulligan Connie J, Existe Alexander, Victor Yves S, Memnon Gladys, Boncy Jacques, Oscar Roland, Fukuda Mark M, Okech Bernard A   +9 more
doaj   +1 more source

Polimorfismos en los genes de dihidrofolato-reductasa (dhfr) y dihidropteroato-sintasa (dhps) y modelado estructural del gen dhps en aislamientos colombianos de Toxoplasma gondii

Biomédica: revista del Instituto Nacional de Salud, 2014
Introducción. No existen reportes sobre las variaciones en la secuencia de los genes blanco de los medicamentos anti-Toxoplasma en aislamientos provenientes de Suramérica. Objetivo.
Liliana Jazmín Cortés, Sofía Duque, Myriam Consuelo López, Diego Moncada, Diego Molina, Jorge Enrique Gómez-Marín, María Luz Gunturiz   +6 more
doaj   +1 more source

Methotrexate – Genotoxic and teratogenic for medical staff of oncology wards?

Medycyna Pracy, 2015
Methotrexate (MTX) is one of the most widely used cytostatic drugs belonging to the folic acid antagonists. It is a substance non-classified as a carcinogen in the European Union and by the International Agency for Research on Cancer (IARC) as there is ...
Małgorzata Kupczewska-Dobecka
doaj   +1 more source

Distribution of Pharmacogenetic Polymorphisms and the Intervention Effects of Folic Acid Combined with Vitamin D in Community-based Patients with H-type Hypertension [PDF]

Zhongguo quanke yixue
Background H-type hypertension seriously affects people's health and quality of life. Currently, the clinical treatment of hypertension mainly selects drugs based on the experience, and the antihypertensive effect is not ideal.
PANG Aimei, GAO Wei, ZHANG Heng, PU Shuangshuang, GUO Lili, FAN Zirong, LIU Haixia, LIU Ruixia
doaj   +1 more source

Metformin and Micronutrient Status in Type 2 Diabetes: Does Polypharmacy Involving Acid-Suppressing Medications Affect Vitamin B12 Levels?

Diabetes, Metabolic Syndrome and Obesity, 2020
Michael Wakeman, David T Archer Faculty of Health and Wellbeing, Sciences Complex, University of Sunderland, Sunderland SR1, UKCorrespondence: Michael WakemanFaculty of Health and Wellbeing, Sciences Complex, University of Sunderland, Sunderland SR1 3SD,
Wakeman M, Archer DT
doaj  

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source