Results 51 to 60 of about 4,299 (147)

Liver stiffness in Fontan patients: the effect of respiration and food intake

Frontiers in Medicine, 2023
ObjectivesFor several years, patients with single ventricle hearts have been palliated according to the Fontan principle. One well known long-term consequence in these patients is the Fontan-associated liver disease and fibrosis, which occurs due to the ...
Annabell Braun, Richard Mühlberg, Marcus Fischer, Nikolaus A. Haas, Zora Meyer   +4 more
doaj   +1 more source

Early‐Onset Digestive System Cancers: Risk Factors and Clinicopathological and Molecular Features Across Organ Sites

Cancer Science, Volume 117, Issue 5, Page 1223-1234, May 2026.
Shared risk factors, clinical features, and tumor characteristics across multiple early‐onset cancer types are shown in this Graphical Abstract. Integrative approaches combining molecular pathology, oncology, and population sciences offer opportunities to clarify underlying mechanisms and help us develop preventive strategies for early‐onset cancers ...
Nobuhiro Nakazawa, Satoko Ugai, Atsushi Kondo, Kosuke Matsuda, Shu Kato, Genki Usui, Shiori Tanaka, Hwa‐Young Lee, Xinyuan Zhang, Hideo Miyagawa, Mai Chan Lau, Hiroshi Saeki, Yukihide Kanemitsu, Andrew T. Chan, Shuji Ogino, Minkyo Song, Juha P. Väyrynen, Tomotaka Ugai   +17 more
wiley   +1 more source

Phenotyping of Fontan‐Associated Renal Physiology and Disease

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
In patients with a Fontan circulation, both kidney function and glomerular injury progressively decline with age, with a stronger decline than in healthy individuals. Additionally, intrarenal haemodynamics in patients with a Fontan circulation demonstrate decreased venous and arterial compliance, evident through elevated venous impedance and renal ...
Gaston van Hassel, Jozine M. ter Maaten, Iris E. Beldhuis, Eryn T. Liem, Bastiaan Zwart, Stephan J. L. Bakker, Rolf M. F. Berger, Joost P. van Melle   +7 more
wiley   +1 more source

REgistry Of Catheter AbLation After Congenital Heart Disease Surgery(REAL‐CHD Registry)

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
Catheter ablation for postoperative CHD‐related arrhythmias is increasingly performed in Japan and can be achieved with acceptable safety. ABSTRACT Background Advances in surgical management have improved long‐term survival in patients with congenital heart disease (CHD), leading to a growing population of adults with postoperative arrhythmias. However,
Hitoshi Mori, Nobuhiro Nishii, Yoshiaki Kato, Takahiko Kinjo, Tsugutoshi Suzuki, Jun Yoshimoto, Shigeru Tateno, Aya Miyazaki, Hisaaki Aoki, Satoshi Higuchi, Koji Nakagawa, Keiko Toyohara, Daiji Takeuchi, Tetsuri Sakai, Kiyotaka Takefuta, Ryuta Henmi, Masayoshi Mori, Daigo Yagishita, Shun Hasegawa, Yuko Matsui, Shonosuke Watanabe, Kensuke Kikuchi, Kunihiro Kani, Yasunori Hiranuma, Toshiya Matsuyama, Kazuhisa Matsumoto, Masataka Narita, Wataru Sasaki, Taisuke Nabeshima, Kota Nagaoka, Takuro Kojima, Ritsushi Kato, Morio Shoda, Naokata Sumitomo   +33 more
wiley   +1 more source

A longitudinal analysis of morphological shape variation of spleen in patients with fontan surgery

Informatics in Medicine Unlocked
Background: Splenic size serves as a surrogate biomarker for predicting portal vein hyper-tension and liver abnormalities in subjects with Fontan Associated Liver Disease (FALD).
Varatharajan Nainamalai, Håvard Bjørke Jenssen, Mostafa Rezaeitaleshmahalleh, Djinaud Prophete, Jordan Gosnell, Sarah Khan, Marcus Haw, Jingfeng Jiang, Joseph Vettukattil   +8 more
doaj   +1 more source

Comparison of Rifampin and Isoniazid for Latent Tuberculosis Infection in Kidney Transplant Candidates: Focus on Tolerability and Treatment Completion

Transplant Infectious Disease, Volume 28, Issue 2, March/April 2026.
This study comparing 4‐month rifampin with 9‐month isoniazid for latent tuberculosis in kidney transplant candidates showed higher treatment completion rates and no transaminase elevations in the rifampin group. However, some patients experienced an increase in blood pressure while taking antihypertensive medications known to interact with rifampin ...
Jacques Simkins, Julia Bini Viotti, Yoichiro Natori, Shweta Anjan, Adela Mattiazzi, Mariella Ortigosa‐Goggins, Giselle Guerra, David Roth, Warren Kupin, Javier A. Pagan, Franco Cabeza, Gaetano Ciancio, Mahmoud Morsi, Michele I. Morris   +13 more
wiley   +1 more source

Effect of liver abnormalities on mortality in Fontan patients: a systematic review and meta-analysis

BMC Cardiovascular Disorders
Background Fontan-associated liver disease (FALD) is one of the most common complications following Fontan procedure, but the impact of FALD on survival outcomes remains controversial.
Xiang Liu, Linjiang Han, Ziqin Zhou, Jiazichao Tu, Jianrui Ma, Jimei Chen   +5 more
doaj   +1 more source

Evaluating the Prevalence of Optimal Neurodevelopmental Outcome at 4.5‐Years in Children Previously on Ventricular Assist Device Support

Pediatric Transplantation, Volume 30, Issue 2, February 2026.
One third of children implanted with a VAD at < 6 years of age will have an optimal neurodevelopmental outcome. Being female and having a VAD implanted after 2015 is associated with an optimal outcome while a neurological insult is associated with a nonoptimal outcome.
Shannon Oliver, Holger Buchholz, Darren H. Freed, De Villiers Jonker, Ari R. Joffe, Mahsa Saeidian, Irina Dinu, Simon Urschel, Tara Pidborochynski, Joseph Atallah, Charlene M. T. Robertson, Jessica Zvonkovic, Jennifer Conway   +12 more
wiley   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

The physiology of thoracic duct pressure and flow: A review of the literature

Physiological Reports, Volume 14, Issue 2, January 2026.
Abstract The thoracic duct (TD) is the largest vessel of the lymphatic system, transporting interstitial fluid, macromolecules, and immune cells into the venous circulation via the lymphovenous junction. Respiratory and circulatory forces have been proposed as key drivers of TD lymph propulsion; however, the literature reports inconsistent findings ...
Sara Moazzam, Lomani A. O'Hagan, Alys R. Clarke, Peter S. Russell, Anthony R. J. Phillips, John A. Windsor, S. Ali Mirjalili   +6 more
wiley   +1 more source