Results 61 to 70 of about 4,299 (147)

Hepatic Fibrosis Is Universal Following Fontan Operation, and Severity is Associated With Time From Surgery: A Liver Biopsy and Hemodynamic Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background Congestive hepatopathy is a recognized complication of Fontan physiology. Data regarding the incidence of hepatopathy and risk factors are lacking.
David J. Goldberg, Lea F. Surrey, Andrew C. Glatz, Kathryn Dodds, Michael L. O'Byrne, Henry C. Lin, Mark Fogel, Jonathan J. Rome, Elizabeth B. Rand, Pierre Russo, Jack Rychik   +10 more
doaj   +1 more source

Pulmonary Vascular Endothelial Dysfunction Is Induced by Nonpulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
Pulmonary vascular disease in patients with single ventricular heart disease is a significant source of morbidity and mortality. Utilizing an integrated investigative platform that included a novel ovine Glenn model, we demonstrate early pulmonary vascular endothelial dysfunction with the initiation of the nonpulsatile pulmonary blood flow that ...
Jonathan Hyde, Michael A. Smith, Naveen Swami, John H. Hwang, Yenchun Chao, Jason Boehme, Gary W. Raff, Casper Noah Nilsson, Wenhui Gong, Gail H. Deutsch, Eric G. Johnson, Ting Wang, Stephen M. Black, Sanjeev A. Datar, Emin Maltepe, Jeffrey R. Fineman   +15 more
wiley   +1 more source

Biventricular Repair of Univentricular Heart Lowers Risk of Liver Disease Compared With the Fontan Operation

JACC: Advances
Background: The Fontan operation is associated with chronic venous hypertension, liver and renal disease, and several other sequelae. The alterative surgical approach, when feasible, a biventricular conversion (BiV), may diminish some of these long-term ...
Muhammad Bakr Ghbeis, MD, Caroline Pane, BS, Rebecca Beroukhim, MD, Eric Feins, MD, Pedro J. del Nido, MD, Lynn A. Sleeper, ScD, Sitaram E. Emani, MD, John N. Kheir, MD   +7 more
doaj   +1 more source

Hepatic Venous Pressure Gradient in Fontan Physiology Has Limited Diagnostic and Prognostic Significance

CJC Open, 2020
Background: Hepatic venous pressure gradient (HVPG) is measure of portal pressure and a prognostic tool in patients with viral and alcoholic cirrhosis; its utility is unknown in patients with Fontan-associated liver disease (FALD).
Alexander C. Egbe, MD, MPH, William R. Miranda, MD, Gruschen R. Veldtman, MD, Rondell P. Graham, MBBS, Patrick S. Kamath, MD   +4 more
doaj   +1 more source

An Otolaryngology‐Focused Risk Stratification for Postoperative Dysphagia in Pediatric Cardiac Surgery

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 6, December 2025.
ABSTRACT Objectives To develop and validate a risk stratification model for postoperative dysphagia in pediatric cardiac surgery patients, focusing on factors relevant to otolaryngologic assessment and implications for Otolaryngology management. Methods Analysis of 174 pediatric patients undergoing cardiac surgery at a tertiary care center between ...
Matthew Zhang, Basir Mansoor, Marlaine Frelier, Cynthia Wang, Yann‐Fuu Kou, Stephen R Chorney, Romaine Johnson   +6 more
wiley   +1 more source

Assessment of Double Outlet Left Ventricle in Pediatrics Using Transthoracic Echocardiography and Computed Tomographic Angiography

Pediatric Discovery, Volume 3, Issue 4, December 2025.
The clinical manifestation of DOLV was atypical. TTE has a relatively high diagnostic accuracy for DOLV in pediatric, which is very valuable for its early detection. ABSTRACT Double outlet left ventricle (DOLV) is a rare congenital cardiac anomaly in which both great arteries originate entirely or predominantly from the morphologic left ventricle.
Xu Zhu, Guangyi Zhong, Xiaojuan Ji, Xue Xiang, Min Zheng, Huina Yan, Rui Li   +6 more
wiley   +1 more source

Mortality Outcomes of Combined Heart and Liver Transplantation and Isolated Heart Transplantation Following Fontan Procedures: A Systematic Review and Meta‐Analysis

Pediatric Transplantation, Volume 29, Issue 7, November 2025.
This meta‐analysis compares mortality rates in Fontan patients undergoing combined heart–liver transplantation (CHLT) versus isolated heart transplantation (HT), showing comparable mortality and reinforcing the importance of comprehensive liver evaluation in transplant candidates.
Oscar Holmvard, Mariana Póvoa‐Corrêa, Adriana Macintyre Innocenzi, Lucio Filgueiras Pacheco, Daniella Braz Parente, Ronir Raggio Luiz, Jessica Pronestino de Lima Moreira, Renata de Mello Perez, Fernanda Padrão Fernandes, Renata Moll‐Bernardes   +9 more
wiley   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, Volume 599, Issue 20, Page 2954-2972, October 2025.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Alterations in Liver Perfusion in Adults With Fontan Circulation as Assessed by Dual Cholate Clearance

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Fontan circulation (FC) in complex congenital heart disease is characterized by altered hemodynamics and associated with Fontan‐associated liver disease. Patients with FC may exhibit abnormalities in cholate clearance due to abnormal perfusion.
Yuli Y. Kim, Annique Nyman, Yuan‐Shung Huang, Alexis Z. Tomlinson, Michael P. McRae, Greg T. Everson, Sumeet Vaikunth, Benjamin Rosenthal, Jack Rychik, Maarouf A. Hoteit   +9 more
doaj   +1 more source

Gut Dysbiosis in Patients With Fontan Circulation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The process underlying Fontan pathophysiology is multifactorial and may include gut dysbiosis (GD). We investigated the presence of GD and elucidated its correlation with Fontan pathophysiology.
Hideo Ohuchi, Ryotaro Asano, Aki Mori, Tomohiko Ishibashi, Daisuke Motooka, Michikazu Nakai, Yoshikazu Nakaoka   +6 more
doaj   +1 more source