Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Buying Practices and Prevalence of Adulteration in Selected Food items in a Rural Area of Wardha District: A Cross - Sectional Study [PDF]
Introduction: Food adulteration in India includes both willful adulteration and substandard food which do not confirm to prescribe food standard. There is striking paucity of reliable data with regard to extent of adulteration and documentation of food ...
Chaudhary, S +4 more
core +1 more source
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
This article, focusing on produce and grain, discusses the environmental and climate change impacts of food production, processing, packaging, and distribution, which ultimately contribute to both economic and social costs.
Czarnezki, Jason J.
core +1 more source
Enhancing National Climate Services (ENACTS) in Ethiopia: A participatory demonstration workshop for Key National and International Development Partners [PDF]
Ethiopia’s National Meteorological Agency’s (NMA) Enhancing National Climate Services (ENACTS) is a collaborative tool developed by the International Research Institute for Climate and Society (IRI), The Earth Institute at Columbia University, National ...
CGIAR Research Program on Climate Change, Agriculture and Food Security
core
Eating behaviours and food cravings; influence of age, sex, BMI and FTO genotype [PDF]
Previous studies indicate that eating behaviours and food cravings are associated with increased BMI and obesity. However, the interaction between these behaviours and other variables such as age, sex, BMI and genetics is complex.
Caroline Dalton +5 more
core +1 more source
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
From Farm to Fork: A Firsthand Investigation into New Hampshire’s Food System [PDF]
Inspired by my first year studying sustainable agriculture and food systems at the University of New Hampshire (UNH), I sought to get a better handle on the food system by diving into a research project with my mentor, Dr.
Papadakis, Alexandra
core +1 more source
Strengthening Climate-Resilient Agricultural Systems in South Asia: CCAFS South Asia Regional Meeting Report [PDF]
State of the art discourse on agriculture and climate change, lays emphasis on the dual role of agriculture in adapting to and mitigating climate change.
CGIAR Research Program on Climate Change, Agriculture and Food Security
core
Transforming food systems through food sovereignty: an Australian urban context [PDF]
This article draws on La Via Campesina's definition of food sovereignty and its potential for reconceptualising food as a basic human right within the dominant Australian food discourse.
Davila, Federico, Dyball, Robert
core +1 more source

