Results 71 to 80 of about 7,013,092 (301)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Beyond the risks to food availability – linking climatic hazard vulnerability with the food access of delta-dwelling households

Food Security, 2019
Although climate-driven hazards have been widely implicated as a key threat to food security in the delta regions of the developing world, the empirical basis of this assertion has centred predominantly on the food availability dimension of food security.
Md. Mofakkarul Islam, Md. Abdullah Al Mamun   +1 more
semanticscholar   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Online grocery purchasing in Mississippi: associations with broadband, rurality, and household characteristics

Frontiers in Nutrition
IntroductionThis study investigates the sociodemographic, economic, and area characteristics associated with Online Grocery Purchasing (OGP) use among adult residents of Mississippi.
Will Davis, Jordan W. Jones, Elizabeth Canales, Ayoung Kim, David R. Buys   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A community-based system dynamics approach suggests solutions for improving healthy food access in a low-income urban environment

PLoS ONE, 2019
Little is known about the mechanisms through which neighborhood-level factors (e.g., social support, economic opportunity) relate to suboptimal availability of healthy foods in low-income urban communities.
Y. Mui, E. Ballard, E. Lopatin, Rachel L. J. Thornton, Keshia M. Pollack Porter, J. Gittelsohn   +5 more
semanticscholar   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Rural Food Insecurity: A Longitudinal Analysis of Low-Income Rural Households with Children in the South

RSF: The Russell Sage Foundation Journal of the Social Sciences, 2022
Researchers have noted large spatial variations in rates of food insecurity. But little research exists on why this is so and the impacts it has on rural families.
Sarah Bowen, Sinikka Elliott, Annie Hardison-Moody   +2 more
doaj   +1 more source