Results 61 to 70 of about 1,529,879 (264)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Impact of agricultural land use changes on food access in Mwatate Sub-County, Taita Taveta County, Kenya

Frontiers in Sustainable Food Systems
IntroductionWhereas Sustainable Development Goal 2 seeks to achieve zero hunger by 2030, food security remains a global challenge. Therefore, SDG 2 aims to achieve sufficient food access through sustainable agriculture. This is in line with the tenets of
Obeka Mwanzi Bonventure, Elisabeth Wacker, Halimu Shauri, Walter Timo de Vries   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Closing the food access gap in rural Mississippi

Journal of Agriculture, Food Systems, and Community Development
Rural Mississippi faces severe health challenges, ranking lowest among all U.S. states in health out­comes and highest in diet-related chronic diseases.
Ivonne Quiroz, Katherine Fraser, Sara Evans Miller, Kevin Coogan, Nevin Cohen   +4 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

“Now I Do Not Eat, it is Just For My Children”: Mapping Food Access Disruption Among Refugees and Migrants in Athens, Greece

Glocality
Despite relatively low rates of food insecurity in Europe, refugees and migrants (RMs) disproportionally experience hunger. In Greece, food access disruption among RMs is a pressing challenge, further exacerbated by current global dynamics such as ...
Leona Klein
doaj   +1 more source

Rural Food Insecurity: A Longitudinal Analysis of Low-Income Rural Households with Children in the South

RSF: The Russell Sage Foundation Journal of the Social Sciences, 2022
Researchers have noted large spatial variations in rates of food insecurity. But little research exists on why this is so and the impacts it has on rural families.
Sarah Bowen, Sinikka Elliott, Annie Hardison-Moody   +2 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Food Insecurity Amongst Urban College Students

Journal of Higher Education and Student Affairs
Food insecurity is a growing concern among college students. With the rising food and housing costs, more students are going hungry. This narrative inquiry provides a greater understanding of food insecurity's impact on the college-going experience for ...
Gerron Scott
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source