Results 201 to 210 of about 245,551 (329)

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

open access: yesHepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu   +16 more
wiley   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

open access: yesBMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah   +9 more
wiley   +1 more source

Metabolic dysfunction‐associated fatty liver disease and excessive alcohol consumption are both independent risk factors for mortality

open access: yesHepatology, EarlyView., 2022
Visualisation of the study desgin, main results and key findings. Abstract Background and Aims MAFLD often cooccurs with excessive alcohol consumption, while its prognostic value in this group remains unclear. We aimed to study the mortality risk of MAFLD in relation to excessive alcohol consumption and its potential interactions.
Laurens A. van Kleef   +2 more
wiley   +1 more source

Gut Microbiota as Targets for Preventing Ovalbumin-Induced Food Allergy. [PDF]

open access: yesNutrients
Shi X   +7 more
europepmc   +1 more source

The Phenolic Content and Bioactivity Assessment of Rubus sanctus Schreber Species with Potential for Food and Ethnopharmacological Uses

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT In this study, the phytochemical content and various biological activities of Rubus sanctus Schreber species, widely distributed in Turkiye and used in folk medicine, were determined. The ethanol extracts of the root and aerial parts of the species were prepared and their bioactive phytochemical composition was identified by liquid ...
Ismail Yener
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

open access: yesHepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario   +12 more
wiley   +1 more source

Self-reported accidental allergic reactions among patients with challenge-verified food allergy. [PDF]

open access: yesClin Transl Allergy
Svendsen SV   +5 more
europepmc   +1 more source

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