Results 81 to 90 of about 908,626 (266)
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
: In this study we wanted to investigate the associations between naturally occurring subclinical intramammary infection (IMI) caused by different etiological agents (i.e., Staphylococcus aureus, Streptococcus agalactiae, Streptococcus uberis, and ...
V. Bisutti +10 more
doaj +1 more source
Intercompartmental communication in senescence
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
Italian local chicken breeds: a comparative analysis of biodiversity on a global scale
Background Chickens, domesticated around 3500 years ago, are crucial in global agriculture, resulting in hundreds of breeds worldwide. In Europe, intensive breeding has led to the creation of numerous distinct commercial lines at the expense of local ...
Filippo Cendron +6 more
doaj +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Methicillin-resistant Staphylococcus aureus (MRSA) poses a serious public health threat due to its zoonotic potential and resistance to several antibiotic classes.
Susanne Sawodny +4 more
doaj +1 more source
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Poly- and perfluoroalkyl substances (PFAS) are environmentally persistent contaminants that pose growing food safety concerns due to their potential for accumulation in edible crops.
Andrea Sabia +6 more
doaj +1 more source
Editorial: Infectious diseases, microbial ecology, and antimicrobial resistance dynamics in food animals. [PDF]
Kandeel SA, Megahed AA.
europepmc +1 more source

