Results 41 to 50 of about 600,477 (264)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Potential Metal Contamination in Foods of Animal Origin—Food Safety Aspects

open access: yesApplied Sciences
This literature review provides an overview of the food safety and toxicological characteristics of various heavy metals and metalloids and the public health significance of their occurrence in food.
József Lehel   +4 more
doaj   +1 more source

Food Chain Processes and Food Quality

open access: yes, 2017
This chapter examines the relationship between the quality of foods and the processes in the food chains that deliver those foods. Food quality is ultimately a question of consumer perception. Actors in the food chain should have the common goal of delivering high-quality food to consumers.
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

AI-Based Predictive Modelling and Alert Framework for Mortality Risk and Cost–Benefit Analysis in Rabbit Production

open access: yesVeterinary Sciences
Mortality events in commercial rabbit production can lead to significant economic losses, highlighting the need for earlier identification of elevated mortality risk at the group level using routinely collected production data.
Szilveszter Csorba   +6 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Scientific Opinion on the risks for public and animal health related to the presence of citrinin in food and feed

open access: yesEFSA Journal, 2012
The European Food Safety Authority (EFSA) was asked by the European Commission to deliver a scientific opinion on the health risks from citrinin in food and feed.
EFSA Panel on Contaminants in the Food Chain (CONTAM)
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Preliminary study of the growth variability of Vibrio parahaemolyticus in simulated gastric digestion fluids

open access: yesFrontiers in Microbiology
Vibrio parahaemolyticus may enter the viable but non-culturable (VBNC) state under specific stress conditions such as low temperature and acidic environments. In this study, we simulated gastric fluid digestion of V. parahaemolyticus followed by transfer
Zheng’ao Zhang   +8 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

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