Results 51 to 60 of about 1,856,984 (314)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

AI-Based Predictive Modelling and Alert Framework for Mortality Risk and Cost–Benefit Analysis in Rabbit Production

Veterinary Sciences
Mortality events in commercial rabbit production can lead to significant economic losses, highlighting the need for earlier identification of elevated mortality risk at the group level using routinely collected production data.
Szilveszter Csorba, Erika Országh, Ákos Józwiák, Zoltán Német, Miklós Süth, Andrea Zentai, Zsuzsa Farkas   +6 more
doaj   +1 more source

Scientific Opinion on the risks for public and animal health related to the presence of citrinin in food and feed

EFSA Journal, 2012
The European Food Safety Authority (EFSA) was asked by the European Commission to deliver a scientific opinion on the health risks from citrinin in food and feed.
EFSA Panel on Contaminants in the Food Chain (CONTAM)
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Preliminary study of the growth variability of Vibrio parahaemolyticus in simulated gastric digestion fluids

Frontiers in Microbiology
Vibrio parahaemolyticus may enter the viable but non-culturable (VBNC) state under specific stress conditions such as low temperature and acidic environments. In this study, we simulated gastric fluid digestion of V. parahaemolyticus followed by transfer
Zheng’ao Zhang, Qiong Wu, Zilong Zhang, Haoran Du, Yixuan Yang, Wenhui Wei, Yuyang Zhao, Xiaowei Wang, Minglu Zhang   +8 more
doaj   +1 more source

Scientific Opinion on the risks to public health related to the presence of chromium in food and drinking water [PDF]

EFSA Journal, 2014
EFSA received a request from the Hellenic Food Authority for a scientific opinion on estimation of the risk to human health from the presence of chromium (Cr) in food, particularly in vegetables, and Cr(VI) in bottled water.
EFSA Panel on Contaminants in the Food Chain (CONTAM)
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Corrigendum: Detection of Aflatoxins in Different Matrices and Food-Chain Positions

Frontiers in Microbiology, 2021
Gabriella Miklós, Cserne Angeli, Árpád Ambrus, Attila Nagy, Valéria Kardos, Andrea Zentai, Kata Kerekes, Zsuzsa Farkas, Ákos Józwiak, Tibor Bartók   +9 more
doaj   +1 more source

Presence of microplastics and nanoplastics in food, with particular focus on seafood

EFSA Journal, 2016
Following a request from the German Federal Institute for Risk Assessment (BfR), the EFSA Panel for Contaminants in the Food Chain was asked to deliver a statement on the presence of microplastics and nanoplastics in food, with particular focus on ...
EFSA Panel on Contaminants in the Food Chain (CONTAM)
doaj   +1 more source