Results 61 to 70 of about 2,423,033 (311)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Kırgız Yemek Kültüründe Yoğurt

İmgelem
Orta Asya’nın en kadim halklarından biri olan Kırgız Türklerinin yemek kültürü yaşadığı coğrafi konuma ve göçebe yaşam tarzına göre şekillenmiştir.
Roza Abdykulova, Kishimjan Eshenkulova
doaj   +1 more source

Kearifan Lokal dalam Membentuk Daya Pangan Lokal Komunitas Molamahu Pulubala Gorontalo

Buletin Al-Turas, 2013
Abstrak Perspektif budaya memandang makanan bukanlah sesuatu yang dipandang semata-mata berhubungan dengan aspek fisiologis dan biologis manusia melainkan secara menyeluruh terserap dalam suatu sistem budaya pangan.
Amir Fadhilah
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Marugame Udon An Analysis of Tenant and Stand-alone Restaurant [PDF]

, 2019
Nowadays, food is being used to spread and exchange the culture of a nation. In Indonesia, particularly in big cities such as Jakarta and Bandung, there are many specialty restaurants that offer an international menu representing the image of a country ...
Handoyo, A. D. (Andreas ), Mariasjarif, F. (Fadilla ), Tiara, A. F. (Adji )   +2 more
core  

CuisineNet: Food Attributes Classification using Multi-scale Convolution Network

, 2018
Diversity of food and its attributes represents the culinary habits of peoples from different countries. Thus, this paper addresses the problem of identifying food culture of people around the world and its flavor by classifying two main food attributes,
Banu, S.F., Jabreel, M., Moreno, A., Puig, D., Radeva, P., Rashwan, H.A., Sarker, M.M.K., Singh, V.K.   +7 more
core   +1 more source

Unravelling technology-acceptance factors influencing farmer use of banana tissue culture planting materials in Central Uganda [PDF]

, 2019
Effective management of plant health is fundamental for food and income security to meet the growing demands of local and global markets. This however requires farmers’ adequate access to quality planting materials under the prevailing contextual and ...
Ajambo, S., Birungi Kyazze, F., Kibwika, P., Kikulwe, Enoch Mutebi, Mulugo, L., Omondi, Bonaventure Aman   +5 more
core   +2 more sources