Results 41 to 50 of about 25,774 (303)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Examining food purchasing patterns from sales data at a full-service grocery store intervention in a former food desert

Preventive Medicine Reports, 2015
Background: The Good Food Junction Grocery Store was opened in a former food desert in the inner city of Saskatoon, Canada. Objective: The purpose of this research was to examine, using grocery store sales data, healthy and less healthful food purchasing
Daniel Fuller, Rachel Engler-Stringer, Nazeem Muhajarine   +2 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Impacts of neighborhood restaurant density on adults’ dietary quality: evidence from an IV-LASSO approach in China

Frontiers in Sustainable Food Systems
The development of the restaurant industry has disrupted food consumption patterns, while evidence on how restaurants impact dietary quality remains limited and inconsistent.
Yalin Tang, Maoran Zhu, Maoran Zhu, Jian Zong, Xuyuan Zheng, Chengfang Liu   +5 more
doaj   +1 more source

Foraging and Food Selection in a Desert Rodent: Diet Shifts of the Sandy Inland Mouse between Population Booms and Busts [PDF]

, 2023
Stephanie J. S. Yip, Chris R. Dickman
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source

Social economic organizations tackling food insecurity amid a booming economy: The development of the Good Food Junction Cooperative in Saskatoon, SK

Canadian Food Studies, 2015
Food insecurity is a phenomenon found around the world, including in developed countries that enjoy a large portion of the world’s wealth. Although the economy of the Canadian province Saskatchewan is currently ‘booming’, a large food desert still ...
Josie Steeves
doaj   +1 more source

Desert locust invasion in Nepal and possible management strategies: A review

Journal of Agriculture and Food Research, 2021
Desert locusts are the harmful pests that feed on every edible substance available on their way. One single mature locust can consume crops equal to its weight.
Meena Pandey, Binita Suwal, Preeti Kayastha, Gresha Suwal, Dipak Khanal   +4 more
doaj   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source