Using a PBPK Model Incorporating Lymphatic Absorption to Predict Food Effect, Multiple Dosing, and Hepatic Impairment of Cannabidiol. [PDF]
Clin Transl SciQian L, Zhou Z.
europepmc +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Prediction of systemic exposure by food effect on a fixed-dose combination of linagliptin and metformin extended-release. [PDF]
Diabetes Obes MetabJeon J +5 more
europepmc +1 more source
The use of microtracers in food-effect trials: An alternative study design for toxic drugs with long half-lives exemplified by the case for alectinib. [PDF]
Clin Transl Sci, 2023 van der Heijden LT +4 more
europepmc +1 more source
The vulnerability of the European agriculture and food system for calamities and geopolitics : a stress test [PDF]
During the 1960s and 1970s, the EU succeeded in becoming largely self-sufficient in food production, thus assuring its food security for the most part.
Burger, C.P.J. +4 more
core +2 more sources
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
Pharmacokinetics and Safety of Fixed-Dose Versus Separate Enavogliflozin/Gemigliptin Combinations, and Food Effect on Enavogliflozin in Healthy Korean Subjects. [PDF]
Clin Transl SciChoi YS +5 more
europepmc +1 more source
THE EFFECT OF NEW FOOD LABELING ON NUTRIENT INTAKES: AN ENDOGENOUS SWITCHING REGRESSION ANALYSIS [PDF]
This paper examines the effect of the new labeling regulations on nutrient intakes using an endogenous switching regression model. Using the 1994 - 96 CSFII/DHKS, we evaluate the impact of food label use on intakes of selected nutrients.Food Consumption ...
Capps, Oral, Jr. +2 more
core +1 more source
Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer +3 more
wiley +1 more source